Recombinant fusion protein of Heparin-Binding Hemagglutinin Adhesin and Fibronectin Attachment Protein (rHBHA-FAP) of Mycobacterium avium subsp. paratuberculosis elicits a strong gamma interferon response in peripheral blood mononuclear cell culture

scientific article published on 09 July 2019

Recombinant fusion protein of Heparin-Binding Hemagglutinin Adhesin and Fibronectin Attachment Protein (rHBHA-FAP) of Mycobacterium avium subsp. paratuberculosis elicits a strong gamma interferon response in peripheral blood mononuclear cell culture is …
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scholarly articleQ13442814

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P356DOI10.1186/S13099-019-0317-6
P932PMC publication ID6615227
P698PubMed publication ID31320935

P50authorAbdollah DerakhshandehQ59695326
Azar Motamedi BoroojeniQ85890213
P2093author name stringLeonardo A Sechi
Masoud Haghkhah
Arsalan Hosseini
Vida Eraghi
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Members of the 30- to 32-kilodalton mycolyl transferase family (Ag85) from culture filtrate of Mycobacterium avium subsp. paratuberculosis are immunodominant Th1-type antigens recognized early upon infection in mice and cattleQ43181626
Innate IFN-gamma production in cattle in response to MPP14, a secreted protein from Mycobacterium avium subsp. ParatuberculosisQ43703817
Epitopes of Mycobacterium avium ssp. paratuberculosis 70kDa heat-shock protein activate bovine helper T cells in outbred cattleQ43762782
MAP3738c and MptD are specific tags of Mycobacterium avium subsp. paratuberculosis infection in type I diabetes mellitus.Q44526156
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The Mycobacterium avium subsp. paratuberculosis 35 kDa protein plays a role in invasion of bovine epithelial cellsQ47708018
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MAP1981c, a Putative Nucleic Acid-Binding Protein, Produced by Mycobacterium avium subsp. paratuberculosis, Induces Maturation of Dendritic Cells and Th1-Polarization.Q55416755
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Differential T and B cell responses against Mycobacterium tuberculosis heparin-binding hemagglutinin adhesin in infected healthy individuals and patients with tuberculosisQ77691317
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In silico screened Mycobacterium avium subsp. paratuberculosis (MAP) recombinant proteins upregulated under stress conditions are immunogenic in sheepQ84740557
HBHA-Induced Polycytotoxic CD4+ T Lymphocytes Are Associated with the Control of Mycobacterium tuberculosis Infection in HumansQ90596073
Immunoreactivity of the Mycobacterium avium subsp. paratuberculosis 19-kDa lipoproteinQ24799371
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Association of Mycobacterium avium subsp. paratuberculosis with multiple sclerosis in Sardinian patientsQ28741088
Expression cloning of gamma interferon-inducing antigens of Mycobacterium avium subsp. paratuberculosisQ33215555
Identification of epitopes of fibronectin attachment protein (FAP-A) of Mycobacterium avium which stimulate strong T-cell responses in miceQ33751888
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Alkyl hydroperoxide reductases C and D are major antigens constitutively expressed by Mycobacterium avium subsp. paratuberculosisQ34003312
Progressive bovine paratuberculosis is associated with local loss of CD4(+) T cells, increased frequency of gamma delta T cells, and related changes in T-cell functionQ34125718
Gene expression profiling of peripheral blood mononuclear cells from cattle infected with Mycobacterium paratuberculosisQ34132600
The Mycobacterium avium subsp. Paratuberculosis protein MAP1305 modulates dendritic cell-mediated T cell proliferation through Toll-like receptor-4Q34180146
Detection of serum antibodies cross-reacting with Mycobacterium avium subspecies paratuberculosis and beta-cell antigen zinc transporter 8 homologous peptides in patients with high-risk proliferative diabetic retinopathyQ34199399
Immune responses to intracellular bacteria.Q34332652
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Mycobacterium paratuberculosis CobT activates dendritic cells via engagement of Toll-like receptor 4 resulting in Th1 cell expansion.Q36385801
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Mycobacterium avium subsp. paratuberculosis fibronectin attachment protein activates dendritic cells and induces a Th1 polarizationQ37256545
No holes barred: invasion of the intestinal mucosa by Mycobacterium avium subsp. paratuberculosisQ37264818
The mycobacterial heparin-binding hemagglutinin is a protective antigen in the mouse aerosol challenge model of tuberculosisQ37624063
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P921main subjectMycobacterium avium aviumQ310728
P304page(s)36
P577publication date2019-07-09
P1433published inGut PathogensQ15817917
P1476titleRecombinant fusion protein of Heparin-Binding Hemagglutinin Adhesin and Fibronectin Attachment Protein (rHBHA-FAP) of Mycobacterium avium subsp. paratuberculosis elicits a strong gamma interferon response in peripheral blood mononuclear cell culture
P478volume11