Acute myeloid leukemia cells secrete microRNA-4532-containing exosomes to mediate normal hematopoiesis in hematopoietic stem cells by activating the LDOC1-dependent STAT3 signaling pathway

scientific article published on 16 December 2019

Acute myeloid leukemia cells secrete microRNA-4532-containing exosomes to mediate normal hematopoiesis in hematopoietic stem cells by activating the LDOC1-dependent STAT3 signaling pathway is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1186/S13287-019-1475-7
P932PMC publication ID6915875
P698PubMed publication ID31842997

P2093author name stringYang Zhao
Chen Zhao
Shanshan Wang
Feng Du
Ling Qi
P2860cites workThe emerging roles of tumor-derived exosomes in hematological malignanciesQ39188856
AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB.Q39415910
Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosminQ40389129
FLT3 mutations in acute myeloid leukemia cell linesQ40610364
Overexpression of a dominant negative form of STAT3 selectively impairs hematopoietic stem cell activityQ40720215
Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemiaQ41925220
Cytosolic YB-1 and NSUN2 are the only proteins recognizing specific motifs present in mRNAs enriched in exosomesQ46397029
Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion.Q47570675
Hematopoietic stem cell-derived exosomes promote hematopoietic differentiation of mouse embryonic stem cells in vitro via inhibiting the miR126/Notch1 pathwayQ48523521
Downregulation of hypermethylated in cancer-1 by - promotes adriamycin resistance in breast cancer cellsQ58765211
Novel STAT3 Inhibitor LDOC1 Targets Phospho-JAK2 for Degradation by Interacting with LNX1 and Regulates the Aggressiveness of Lung CancerQ61799008
Allogeneic hematopoietic stem-cell transplantation for patients 50 years or older with myelodysplastic syndromes or secondary acute myeloid leukemiaQ82236404
Exosomes in acute myeloid leukemia inhibit hematopoiesisQ88915677
Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cellsQ90463779
MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemiaQ24655915
Hematopoietic stem cell niche maintenance during homeostasis and regenerationQ26865273
The prognostic and functional role of microRNAs in acute myeloid leukemiaQ27693865
Linear models and empirical bayes methods for assessing differential expression in microarray experimentsQ27860758
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affy--analysis of Affymetrix GeneChip data at the probe levelQ29547353
Exosomes: extracellular organelles important in intercellular communicationQ29620346
Phase I study of OPB-51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed/refractory hematological malignanciesQ33422320
microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemiaQ33730103
LDOC1 mRNA is differentially expressed in chronic lymphocytic leukemia and predicts overall survival in untreated patientsQ34924406
Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitorQ35030931
Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterationsQ35606336
LDOC1 inhibits proliferation and promotes apoptosis by repressing NF-κB activation in papillary thyroid carcinomaQ36348701
Prediction of human microRNA targetsQ36587289
STAT3 as a target for inducing apoptosis in solid and hematological tumorsQ37029162
Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes)Q37040486
Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cellsQ37676784
Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implicationsQ37827283
Exosomal RNA as biomarkers and the therapeutic potential of exosome vectors.Q38002919
Exosomes in tumor microenvironment influence cancer progression and metastasisQ38091978
The role of miR-150 in normal and malignant hematopoiesisQ38129726
Plasma-derived exosomes in acute myeloid leukemia for detection of minimal residual disease: are we ready?Q38886247
Exosomes: Therapy delivery tools and biomarkers of diseasesQ39137208
P4510describes a project that usesImageJQ1659584
limmaQ112236343
affyQ113334509
P433issue1
P921main subjectacute myeloid leukemiaQ264118
hemopoiesisQ919283
P304page(s)384
P577publication date2019-12-16
P1433published inStem Cell Research & TherapyQ14390536
P1476titleAcute myeloid leukemia cells secrete microRNA-4532-containing exosomes to mediate normal hematopoiesis in hematopoietic stem cells by activating the LDOC1-dependent STAT3 signaling pathway
P478volume10

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cites work (P2860)
Q112715933Bone Marrow Mesenchymal Stem Cells-Derived Exosomal miR-425-5p Inhibits Acute Myeloid Leukemia Cell Proliferation, Apoptosis, Invasion and Migration by Targeting WTAP
Q112745508Hyperleukocytic Acute Leukemia Circulating Exosomes Regulate HSCs and BM-MSCs

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