Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51

scientific article published on 01 May 2019

Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1126/SCITRANSLMED.AAV4508
P932PMC publication ID6626544
P698PubMed publication ID31092693

P50authorSusan ScanlonQ57024044
Zhong YunQ61163872
Alanna R KaplanQ61943873
Sebastian OeckQ85467960
Peter M GlazerQ85479086
P2093author name stringYanfeng Liu
Hoon Kim
P2860cites workChronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance.Q50649984
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Olaparib combined with abiraterone in patients with metastatic castration-resistant prostate cancer: a randomised, double-blind, placebo-controlled, phase 2 trialQ89029416
Overall survival and updated progression-free survival outcomes in a randomized phase II study of combination cediranib and olaparib versus olaparib in relapsed platinum-sensitive ovarian cancerQ91500865
XRCC3 promotes homology-directed repair of DNA damage in mammalian cellsQ24597771
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriersQ27851474
Combination cediranib and olaparib versus olaparib alone for women with recurrent platinum-sensitive ovarian cancer: a randomised phase 2 studyQ27853070
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategyQ27860519
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymeraseQ28131711
AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancerQ28251373
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(18)F-fluoromisonidazole kinetic modeling for characterization of tumor perfusion and hypoxia in response to antiangiogenic therapyQ32179417
2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.Q33698756
Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130.Q33719652
Intermittent hypoxia-induced protein phosphatase 2A activation reduces PC12 cell proliferation and differentiationQ33759500
Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment.Q34300803
Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.Q35049271
Characterization of Cardiac Glycoside Natural Products as Potent Inhibitors of DNA Double-Strand Break Repair by a Whole-Cell Double Immunofluorescence AssayQ35940003
Autophosphorylation-activated protein kinase phosphorylates and inactivates protein phosphatase 2AQ36178824
Acute vascular response to cediranib treatment in human non-small-cell lung cancer xenografts with different tumour stromal architecture.Q36270034
Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinomaQ37369575
The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1α Levels and Colorectal Cancer Cell Survival under Hypoxia.Q37654508
Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trialQ38654552
Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cellsQ39166616
Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA MutationQ39348799
Hypoxia-induced epigenetic regulation and silencing of the BRCA1 promoterQ39525228
Combenefit: an interactive platform for the analysis and visualization of drug combinations.Q39788218
Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxiaQ40227628
Hypoxic stress facilitates acute activation and chronic downregulation of fanconi anemia proteins.Q42024219
Isolation and initial characterization of the BRCA2 promoterQ42479799
Oxidative stress induces protein phosphatase 2A-dependent dephosphorylation of the pocket proteins pRb, p107, and p130.Q44350742
Protein phosphatase 2A associates with Rb2/p130 and mediates retinoic acid-induced growth suppression of ovarian carcinoma cellsQ44547316
Hypoxia-induced down-regulation of BRCA1 expression by E2Fs.Q47673689
Androgen receptor inhibitor-induced "BRCAness" and PARP inhibition are synthetically lethal for castration-resistant prostate cancerQ48110323
P433issue492
P577publication date2019-05-01
P1433published inScience Translational MedicineQ1573955
P1476titleCediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51
P478volume11

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cites work (P2860)
Q90827979Choosing wisely: Selecting PARP inhibitor combinations to promote anti-tumor immune responses beyond BRCA mutations
Q90324835Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance
Q92541840Harnessing DNA Double-Strand Break Repair for Cancer Treatment
Q90671008PARP inhibitor combinations in prostate cancer
Q95824308Preemptive Homology-Directed DNA Repair Fosters Complex Genomic Rearrangements in Hepatocellular Carcinoma
Q98164379Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence
Q89727327Therapeutic Application of PARP Inhibitors in Neuro-Oncology

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