HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo

scientific article published on 06 July 2019

HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MOLMET.2019.07.005
P932PMC publication ID6822257
P698PubMed publication ID31327756

P50authorMaarit Hölttä-VuoriQ48156326
Lauri VanharantaQ90123739
Burcin GungorQ92057282
Elina IkonenQ23039778
P2093author name stringThomas Kirkegaard
Nikolaj H T Petersen
Päivi M Ojala
Silvia Gramolelli
Juho Pirhonen
P2860cites workThe growing world of small heat shock proteins: from structure to functionsQ39212393
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Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology.Q39746539
Live cell multicolor imaging of lipid droplets with a new dye, LD540.Q39797768
Transcriptional regulation of the human Liver X Receptor α gene by Hepatocyte Nuclear Factor 4α.Q40182912
Differential effects of HDL subpopulations on cellular ABCA1- and SR-BI-mediated cholesterol effluxQ40390167
The atheroprotective properties of Hsp70: a role for Hsp70-endothelial interactions?Q40452360
Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.Q40751982
Cellular Chaperones As Therapeutic Targets in ALS to Restore Protein Homeostasis and Improve Cellular FunctionQ41699630
Heat shock protein 90 inhibitors attenuate inflammatory responses in atherosclerosisQ43162731
Human heat shock protein 70 (Hsp70) as a peripheral membrane proteinQ43500605
Knock-down of the oxysterol receptor LXRα impairs cholesterol efflux in human primary macrophages: lack of compensation by LXRβ activation.Q43647722
BODIPY-cholesterol: a new tool to visualize sterol trafficking in living cells and organismsQ46469037
Increased serum levels of heat shock protein 70 are associated with low risk of coronary artery diseaseQ47934879
Targeting HSP90 Ameliorates Nephropathy and Atherosclerosis Through Suppression of NF-κB and STAT Signaling Pathways in Diabetic Mice.Q50580624
Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian CellsQ57025345
Separation of White Blood CellsQ59080094
HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokineQ73606601
Heat stress-induced nuclear transport mediated by Hikeshi confers nuclear function of Hsp70sQ87910210
Mechanisms of cellular cholesterol compartmentalization: recent insightsQ89362478
Control of mRNA decay by heat shock-ubiquitin-proteasome pathwayQ22009394
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONQ25939000
Metabolic functions of FABPs--mechanisms and therapeutic implicationsQ26799705
ATP-binding cassette transporters, atherosclerosis, and inflammationQ27003068
Molecular mechanisms of cellular cholesterol effluxQ27021139
The human HSP70 family of chaperones: where do we stand?Q28071416
HSP90 at the hub of protein homeostasis: emerging mechanistic insightsQ29616824
Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafishQ33709903
The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophagesQ33837099
FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages.Q33854428
Endoplasmic reticulum-associated degradation of Niemann-Pick C1: evidence for the role of heat shock proteins and identification of lysine residues that accept ubiquitinQ33888627
Extracellular heat shock protein 70 (HSPA1A) and classical vascular risk factors in a general populationQ34505818
Heat shock protein-based therapy as a potential candidate for treating the sphingolipidoses.Q34539778
A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterolQ35561997
High fat plus high cholesterol diet lead to hepatic steatosis in zebrafish larvae: a novel model for screening anti-hepatic steatosis drugsQ36292759
Macrophage Phenotype and Function in Different Stages of AtherosclerosisQ36602809
Hydroximic acid derivatives: pleiotropic HSP co-inducers restoring homeostasis and robustness.Q38037746
The role of heat shock proteins in atherosclerosisQ38229874
Coupling of Ribostasis and Proteostasis: Hsp70 Proteins in mRNA MetabolismQ38593778
Highly efficient transfection of human THP-1 macrophages by nucleofection.Q38956094
Heat Shock Proteins and Cancer.Q39052679
P4510describes a project that usesImageJQ1659584
P304page(s)135-143
P577publication date2019-07-06
P1433published inMolecular MetabolismQ27724805
P1476titleHSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo
P478volume28