Intravitreal Therapy Against the Complement Factor C5 Prevents Retinal Degeneration in an Experimental Autoimmune Glaucoma Model

scientific article published on 02 December 2019

Intravitreal Therapy Against the Complement Factor C5 Prevents Retinal Degeneration in an Experimental Autoimmune Glaucoma Model is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FPHAR.2019.01381
P932PMC publication ID6901014
P698PubMed publication ID31849650

P50authorH. Burkhard DickQ108312652
P2093author name stringMarc Schargus
Sara C Gomes
Sabrina Reinehr
Stephanie C Joachim
Gesa Stute
Caroline J Gassel
M Ali Asaad
P2860cites workThe number of people with glaucoma worldwide in 2010 and 2020Q24679554
Spectral-domain optical coherence tomography of the rodent eye: highlighting layers of the outer retina using signal averaging and comparison with histologyQ27334561
Ca2+-induced apoptosis through calcineurin dephosphorylation of BADQ28140882
The a-wave of the dark adapted electroretinogram in glaucomas: are photoreceptors affected?Q28361097
Oxidative stress and the regulation of complement activation in human glaucomaQ28577665
C5b-9 membrane attack complex mediates endothelial cell apoptosis in experimental glomerulonephritisQ28578796
Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCRQ29400573
Swelling and loss of photoreceptors in chronic human and experimental glaucomasQ30839393
Changes in the inner and outer retinal layers after acute increase of the intraocular pressure in adult albino Swiss miceQ30986373
Retinal synthesis and deposition of complement components induced by ocular hypertension.Q33242506
Altered nitric oxide system in patients with open-angle glaucomaQ33281593
IgG antibody patterns in aqueous humor of patients with primary open angle glaucoma and pseudoexfoliation glaucomaQ33300223
Sera of glaucoma patients show autoantibodies against myelin basic protein and complex autoantibody profiles against human optic nerve antigensQ33314556
Calcineurin cleavage is triggered by elevated intraocular pressure, and calcineurin inhibition blocks retinal ganglion cell death in experimental glaucomaQ33917505
Complement mediated apoptosis leads to the loss of retinal ganglion cells in animal model of glaucomaQ33984464
Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucomaQ34755301
Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucomaQ35056596
Complement gene expression and regulation in mouse retina and retinal pigment epithelium/choroidQ35068037
The pathophysiology and treatment of glaucoma: a reviewQ35168230
Laser-induced ocular hypertension in adult rats does not affect non-RGC neurons in the ganglion cell layer but results in protracted severe loss of cone-photoreceptors.Q35541085
The immune system and glaucomaQ35691309
In Vivo Imaging of Fluorescent Probes Linked to Antibodies Against Human and Rat Vascular Endothelial Growth FactorQ35939928
Optic Nerve Head Blood Flow, as Measured by Laser Speckle Flowgraphy, Is Significantly Reduced in Preperimetric GlaucomaQ36012155
Autoimmunity and glaucomaQ37095751
Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligandQ37195253
The role of glia, mitochondria, and the immune system in glaucomaQ37401610
The case for autoimmunity in glaucomaQ37783777
Does autoimmunity play a part in the pathogenesis of glaucoma?Q38094462
Retinal ganglion cells: Energetics, compartmentation, axonal transport, cytoskeletons and vulnerabilityQ38124635
Specific Inner Retinal Layer Cell Damage in an Autoimmune Glaucoma Model Is Induced by GDNF With or Without HSP27.Q38759153
Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosisQ38904200
Evaluating retinal ganglion cell loss and dysfunctionQ38927439
Multiple signal messengers generated by terminal complement complexes and their role in terminal complement complex eliminationQ39260087
Immune response against ocular tissues after immunization with optic nerve antigens in a model of autoimmune glaucomaQ39366776
Complex autoantibody repertoires in patients with glaucomaQ39677385
Therapeutic Inhibition of Complement: Well Worth the RiskQ40249453
Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brainQ40306336
Serum autoantibodies to alpha-fodrin are present in glaucoma patients from Germany and the United StatesQ40347336
Physiology and pathophysiology of complement: progress and trends.Q40380370
Protective effects on the retina after ranibizumab treatment in an ischemia modelQ41363983
Early remodelling of the extracellular matrix proteins tenascin-C and phosphacan in retina and optic nerve of an experimental autoimmune glaucoma modelQ41592935
Tracking longitudinal retinal changes in experimental ocular hypertension using the cSLO and spectral domain-OCT.Q41966541
Intravitreal Injection of Bone Marrow Mesenchymal Stem Cells in Patients with Advanced Retinitis Pigmentosa; a Safety StudyQ42317934
The potential role of glutamate transporters in the pathogenesis of normal tension glaucomaQ42748164
Simultaneous Complement Response via Lectin Pathway in Retina and Optic Nerve in an Experimental Autoimmune Glaucoma Model.Q42748914
Loss of retinal function in aged DBA/2J mice - New insights into retinal neurodegenerationQ42910603
Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice.Q43096209
Systemic and local anti-C5 therapy reduces the disease severity in experimental autoimmune uveoretinitis.Q43225419
Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease.Q44241464
Apoptotic retinal ganglion cell death in an autoimmune glaucoma model is accompanied by antibody depositions.Q45926332
Analysis of autoantibodies against human retinal antigens in sera of patients with glaucoma and ocular hypertensionQ46694030
HSP27 immunization reinforces AII amacrine cell and synapse damage induced by S100 in an autoimmune glaucoma modelQ47611400
Rat retinal microglial cells under normal conditions, after optic nerve section, and after optic nerve section and intravitreal injection of trophic factors or macrophage inhibitory factorQ48268120
Systemic circulatory parameters. comparison between patients with normal tension glaucoma and normal subjects using ambulatory monitoringQ48686172
Autoreactive antibodies and loss of retinal ganglion cells in rats induced by immunization with ocular antigensQ48834661
Real-World Results of Intravitreal Ranibizumab, Bevacizumab, or Triamcinolone for Diabetic Macular EdemaQ50097258
Concentration-Dependent Inner Retina Layer Damage and Optic Nerve Degeneration in a NMDA ModelQ50151785
Different Ipsi- and Contralateral Glial Responses to Anti-VEGF and Triamcinolone Intravitreal Injections in Rats.Q51662674
Systemic ocular antigen immunization leads only to a minor secondary immune response.Q53128844
S100 alone has the same destructive effect on retinal ganglion cells as in combination with HSP 27 in an autoimmune glaucoma model.Q53647549
Microglia in the optic nerve head and the region of parapapillary chorioretinal atrophy in glaucoma.Q53926835
Autoantibodies to small heat shock proteins in glaucoma.Q53943140
Analysis of complement expression in light-induced retinal degeneration: synthesis and deposition of C3 by microglia/macrophages is associated with focal photoreceptor degeneration.Q54373091
S100B immunization triggers NFκB and complement activation in an autoimmune glaucoma model.Q55507765
Fewer Functional Deficits and Reduced Cell Death after Ranibizumab Treatment in a Retinal Ischemia Model.Q55692320
The terminal sequence of complement plays an essential role in antibody-mediated renal cell apoptosisQ77852567
Manometric calibration and comparison of TonoLab and TonoPen tonometers in rats with experimental glaucoma and in normal miceQ79360264
Primary open-angle glaucomaQ80122027
Antibodies to alpha B-crystallin, vimentin, and heat shock protein 70 in aqueous humor of patients with normal tension glaucoma and IgG antibody patterns against retinal antigen in aqueous humorQ80572007
Mitochondrial abnormalities in patients with primary open-angle glaucomaQ83839662
Retinal and Optic Nerve Damage is Associated with Early Glial Responses in an Experimental Autoimmune Glaucoma ModelQ87041812
[Diurnal Fluctuations of Intraocular Pressure, Blood Pressure, and Ocular Perfusion Pressure in Glaucoma Patients]Q87077947
Loss of inner retinal neurons after retinal ischemia in ratsQ87609013
European Glaucoma Society Terminology and Guidelines for Glaucoma, 4th Edition - Chapter 2: Classification and terminologySupported by the EGS Foundation: Part 1: Foreword; Introduction; Glossary; Chapter 2 Classification and TerminologyQ87867736
[Complement activation after induction of ocular hypertension in an animal model]Q88104982
Loss of retinal ganglion cells in a new genetic mouse model for primary open-angle glaucomaQ92391828
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P921main subjectretinal degenerationQ3043268
P304page(s)1381
P577publication date2019-12-02
P1433published inFrontiers in PharmacologyQ2681208
P1476titleIntravitreal Therapy Against the Complement Factor C5 Prevents Retinal Degeneration in an Experimental Autoimmune Glaucoma Model
P478volume10