R-spondin 2-LGR4 system regulates growth, migration and invasion, epithelial-mesenchymal transition and stem-like properties of tongue squamous cell carcinoma via Wnt/β-catenin signaling

scientific article published on 13 May 2019

R-spondin 2-LGR4 system regulates growth, migration and invasion, epithelial-mesenchymal transition and stem-like properties of tongue squamous cell carcinoma via Wnt/β-catenin signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.EBIOM.2019.03.076
P932PMC publication ID6603804
P698PubMed publication ID31097406

P2093author name stringJing Yang
Yuanyuan Li
Zhi Wang
Liping Zhang
Weizhen Zhang
Yan Song
Bin Cheng
Xianyue Ren
Juan Xia
Zihang Ling
P2860cites workIsolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signalingQ22010178
Reviewing and reconsidering invasion assays in head and neck cancerQ24289407
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signalingQ24307371
Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylationQ24310980
The basics of epithelial-mesenchymal transitionQ24652992
A transposon-based genetic screen in mice identifies genes altered in colorectal cancerQ24655169
LGR4 and Its Role in Intestinal Protection and Energy MetabolismQ26784535
Cellular signaling and biological functions of R-spondinsQ27023891
Integrative clinical genomics of advanced prostate cancerQ27853170
Epithelial-mesenchymal transitions in development and diseaseQ27860630
High bat (Chiroptera) diversity in the Early Eocene of IndiaQ28239143
Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistanceQ28269714
Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasisQ28283104
The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular developmentQ28511252
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?Q29547559
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal CompositionQ29615853
Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell nicheQ30495954
R-Spondin proteins: a novel link to beta-catenin activationQ33992278
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.Q34045380
R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesisQ34356591
R-spondin1 is essential in sex determination, skin differentiation and malignancy.Q34573938
Analysis of LGR4 receptor distribution in human and mouse tissuesQ35036103
Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness.Q35768268
The fallacy of epithelial mesenchymal transition in neoplasiaQ36197878
Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotypeQ36527994
Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion frontQ36848899
Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenanceQ36920489
Metastasis of squamous cell carcinoma of the oral tongueQ36928038
Recurrent R-spondin fusions in colon cancerQ36949683
Global epidemiology of oral and oropharyngeal cancerQ37274268
ADAMTS6 suppresses tumor progression via the ERK signaling pathway and serves as a prognostic marker in human breast cancerQ37641594
Cancer stem cells: the promise and the potential.Q38403816
Cancer stem cells and field cancerization of oral squamous cell carcinoma.Q38446867
RSPO2 suppresses colorectal cancer metastasis by counteracting the Wnt5a/Fzd7-driven noncanonical Wnt pathwayQ38733300
Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer TypesQ38807589
RSPO2 Enhances Canonical Wnt Signaling to Confer Stemness-Associated Traits to Susceptible Pancreatic Cancer CellsQ38900256
RSPO2-LGR5 signaling has tumour-suppressive activity in colorectal cancer.Q39029239
Overview of the 8th Edition TNM Classification for Head and Neck Cancer.Q39337270
Rspo2/Int7 regulates invasiveness and tumorigenic properties of mammary epithelial cells.Q39512092
FOXQ1 is overexpressed in colorectal cancer and enhances tumorigenicity and tumor growthQ39741505
RSPO2 enriches LGR5(+) spheroid colon cancer stem cells and promotes its metastasis by epithelial-mesenchymal transitionQ40683197
PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 ExpressionQ47103505
The Role of CD44 and Cancer Stem CellsQ47684013
Targeting cancer stem cell signature gene SMOC-2 Overcomes chemoresistance and inhibits cell proliferation of endometrial carcinoma.Q64937696
An actionable axis linking NFATc2 to EZH2 controls the EMT-like program of melanoma cellsQ91312630
P4510describes a project that usesImageJQ1659584
P921main subjectcell migrationQ189092
tongue squamous cell carcinomaQ28757362
P1104number of pages14
P304page(s)275-288
P577publication date2019-05-13
P1433published inEBioMedicineQ24912341
P1476titleR-spondin 2-LGR4 system regulates growth, migration and invasion, epithelial-mesenchymal transition and stem-like properties of tongue squamous cell carcinoma via Wnt/β-catenin signaling
P478volume44

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cites work (P2860)
Q101136375HPV+ve/-ve oral-tongue cancer stem cells: A potential target for relapse-free therapy
Q92252772Understanding the role of the R-spondin 2-LGR4 system in tongue squamous cell carcinoma progression

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