Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes

scientific article published on 16 May 2019

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1084/JEM.20182386
P932PMC publication ID6605759
P698PubMed publication ID31097468

P50authorHemraj DodiyaQ57044316
Jack A GilbertQ88139527
Shabana M ShaikQ92088881
Jeffrey LeibowitzQ92088887
Sangram S SisodiaQ92088891
P2093author name stringOleg Butovsky
Xulun Zhang
Thomas Kuntz
Xiaoqiong Zhang
Neil Gottel
Caroline Baufeld
P2860cites workTREM2 Variants in Alzheimer's DiseaseQ22250873
MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transformQ24540347
The Indispensable Roles of Microglia and Astrocytes during Brain DevelopmentQ28067530
Induction of intestinal Th17 cells by segmented filamentous bacteriaQ28131638
Neuroinflammation in Alzheimer's diseaseQ28259238
Identification of a unique TGF-β-dependent molecular and functional signature in microgliaQ28303557
FastTree 2--approximately maximum-likelihood trees for large alignmentsQ28748616
Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARBQ29547254
An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune systemQ29614267
Normal gut microbiota modulates brain development and behaviorQ29616855
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolitesQ29619788
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association studyQ30459046
DADA2: High-resolution sample inference from Illumina amplicon dataQ31099919
Late onset Alzheimer's disease genetics implicates microglial pathways in disease riskQ33733863
New insights on the role of microglia in synaptic pruning in health and diseaseQ33821505
Role of the gut microbiota in immunity and inflammatory diseaseQ34036490
Host microbiota constantly control maturation and function of microglia in the CNS.Q34478756
Commensal bacteria protect against food allergen sensitizationQ34583618
Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic developmentQ34778122
How informative is the mouse for human gut microbiota research?Q34818253
Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathologyQ35016226
Finding the missing links among metabolites, microbes, and the hostQ35192230
Peripheral education of the immune system by colonic commensal microbiota.Q35341308
The gut microbiota influences blood-brain barrier permeability in miceQ35413892
Beneficial effects of soy milk and fiber on high cholesterol diet-induced alteration of gut microbiota and inflammatory gene expression in ratsQ35492838
Analysis of composition of microbiomes: a novel method for studying microbial compositionQ35668886
Colonic bacterial composition in Parkinson's disease.Q35693083
Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish MutualismQ35959437
The Central Nervous System and the Gut Microbiome.Q36182979
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's DiseaseQ36212145
Tau positron emission tomographic imaging in aging and early Alzheimer diseaseQ36535275
Systemic infections and inflammation affect chronic neurodegenerationQ36707203
Gender and autoimmunityQ36835130
Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid betaQ36996975
Alterations of the human gut microbiome in multiple sclerosis.Q37060934
Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's diseaseQ37116609
The X-files in immunity: sex-based differences predispose immune responsesQ37252714
Gender bias in autoimmunity is influenced by microbiota.Q37294725
Compartmentalized and systemic control of tissue immunity by commensalsQ37352741
Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiotaQ37631109
Stress induces endotoxemia and low-grade inflammation by increasing barrier permeabilityQ38510131
Microglia Function in Central Nervous System Development and PlasticityQ38549720
Age-specific and sex-specific prevalence of cerebral β-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50-95 years: a cross-sectional studyQ38812890
Microglia across the lifespan: from origin to function in brain development, plasticity and cognitionQ38814802
The Potential Role of Gut-Derived Inflammation in Multiple System Atrophy.Q38944057
Cortical ¹¹C-PIB uptake is associated with age, APOE genotype, and gender in "healthy aging".Q39236818
Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderlyQ39254233
The ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE.Q40670684
Alterations in the mouse cecum and its flora produced by antibacterial drugsQ41523939
Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer's diseaseQ41620470
Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in miceQ42263596
Gut microbiome alterations in Alzheimer's diseaseQ42670350
In-vivo measurement of activated microglia in dementiaQ43713539
Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer's Mouse Model.Q46438685
Alzheimer's Disease Histological and Behavioral Manifestations in Transgenic Mice Correlate with Specific Gut Microbiome StateQ46451309
Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific MannerQ47560330
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative DiseasesQ47568641
Recent developments in understanding the role of the gut microbiota in brain health and diseaseQ47808638
Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity.Q48271850
Microglia development follows a stepwise program to regulate brain homeostasisQ48659057
Early and protective microglial activation in Alzheimer's disease: a prospective study using 18F-DPA-714 PET imaging.Q48828528
Evaluation of Amyloid Protective Factors and Alzheimer Disease Neurodegeneration Protective Factors in Elderly Individuals.Q51052076
Shifts in gut microbiota composition in an APP/PSS1 transgenic mouse model of Alzheimer's disease during lifespan.Q51759801
Microglia in Health and Disease.Q52918308
Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity.Q54468190
Sex-Specific Features of Microglia from Adult Mice.Q55461089
The microbiome-gut-brain axis: from bowel to behaviorQ57513693
Gut Microbiota is Altered in Patients with Alzheimer’s DiseaseQ57891363
Innate immune memory in the brain shapes neurological disease hallmarksQ59071784
Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaintsQ60637418
P4510describes a project that usesImageJQ1659584
P433issue7
P921main subjectmicrogliaQ1622829
P304page(s)1542-1560
P577publication date2019-05-16
P1433published inJournal of Experimental MedicineQ3186912
P1476titleSex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes
P478volume216