Dissection of GTPase-activating proteins reveals functional asymmetry in the COPI coat of budding yeast

scientific article published on 29 August 2019

Dissection of GTPase-activating proteins reveals functional asymmetry in the COPI coat of budding yeast is …
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scholarly articleQ13442814

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P356DOI10.1242/JCS.232124
P932PMC publication ID6737914
P698PubMed publication ID31331965

P50authorAnne SpangQ38320634
Eric C ArakelQ38589419
Blanche Schwappach-PignataroQ38589444
Martina HuranovaQ92090487
Alejandro F EstradaQ92090488
E-Ming RauQ92090493
P2860cites workDecoding of sorting signals by coatomer through a GTPase switch in the COPI coat complexQ22253875
Biochemical characterization of Rab3-GTPase-activating protein reveals a mechanism similar to that of Ras-GAPQ22254280
Insights into COPII coat nucleation from the structure of Sec23.Sar1 complexed with the active fragment of Sec31Q24656578
An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomesQ24671983
ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coatQ24672898
Gamma-COP appendage domain - structure and functionQ27642838
A Structure-Based Mechanism for Arf1-Dependent Recruitment of Coatomer to MembranesQ27677041
VESICULAR TRANSPORT. A structure of the COPI coat and the role of coat proteins in membrane vesicle assemblyQ27701544
Requirement for a GTPase-activating protein in vesicle budding from the endoplasmic reticulumQ27931640
Retrograde transport from the yeast Golgi is mediated by two ARF GAP proteins with overlapping function.Q27931738
The COPI system: molecular mechanisms and functionQ37561802
Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI traffickingQ39915480
AMP-activated protein kinase phosphorylates Golgi-specific brefeldin A resistance factor 1 at Thr1337 to induce disassembly of Golgi apparatusQ40038641
Differential localization of coatomer complex isoforms within the Golgi apparatus.Q40159089
Dissection of COPI and Arf1 dynamics in vivo and role in Golgi membrane transportQ40733038
Uptake by COPI-coated vesicles of both anterograde and retrograde cargo is inhibited by GTPgammaS in vitroQ41008614
9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments.Q41056362
Snf1 Phosphorylates Adenylate Cyclase and Negatively Regulates Protein Kinase A-dependent Transcription in Saccharomyces cerevisiae.Q41071778
Interaction of SNAREs with ArfGAPs precedes recruitment of Sec18p/NSF.Q41812787
Full-length structural model of RET3 and SEC21 in COPI: identification of binding sites on the appendage for accessory protein recruitment motifsQ42219045
ArfGAP1 responds to membrane curvature through the folding of a lipid packing sensor motif.Q42268960
GTP hydrolysis by arf-1 mediates sorting and concentration of Golgi resident enzymes into functional COP I vesiclesQ42680908
ARF-GAP-mediated interaction between the ER-Golgi v-SNAREs and the COPI coatQ42917503
ArfGAP1 interacts with coat proteins through tryptophan-based motifsQ43138454
Regulation of GTP hydrolysis on ADP-ribosylation factor-1 at the Golgi membraneQ43761081
Lipid packing sensed by ArfGAP1 couples COPI coat disassembly to membrane bilayer curvatureQ44679419
COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signalQ46465193
The structure of the COPI coat determined within the cellQ47161945
GTP hydrolysis by ADP-ribosylation factor is dependent on both an ADP-ribosylation factor GTPase-activating protein and acid phospholipidsQ48141237
The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding proteinQ48333124
Distinct role of subcomplexes of the COPI coat in the regulation of ArfGAP2 activity.Q50501587
The yeast Arf-GAP Glo3p is required for the endocytic recycling of cell surface proteins.Q53389041
Phosphoproteomic analysis identifies proteins involved in transcription-coupled mRNA decay as targets of Snf1 signaling.Q54339361
The protein histidine phosphatase LHPP is a tumour suppressor.Q58450463
The Arf1p GTPase-activating protein Glo3p executes its regulatory function through a conserved repeat motif at its C-terminusQ58480491
GAPDH inhibits intracellular pathways during starvation for cellular energy homeostasisQ59094553
The GAP Domain and the SNARE, Coatomer and Cargo Interaction Region of the ArfGAP2/3 Glo3 are Sufficient for Glo3 FunctionQ60542329
N-terminal hydrophobic residues of the G-protein ADP-ribosylation factor-1 insert into membrane phospholipids upon GDP to GTP exchangeQ73244046
Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysisQ74670422
Competition between the golgin Imh1p and the GAP Gcs1p stabilizes activated Arl1p at the late-GolgiQ84531364
Reconstitution of retrograde transport from the Golgi to the ER in vitroQ27933882
The Gcs1 Arf-GAP mediates Snc1,2 v-SNARE retrieval to the Golgi in yeastQ27935783
The ArfGAP Glo3 is required for the generation of COPI vesiclesQ27936556
Comprehensive characterization of genes required for protein folding in the endoplasmic reticulumQ27937991
Dynamics of the COPII coat with GTP and stable analoguesQ27939261
Sequence and structure-based prediction of eukaryotic protein phosphorylation sitesQ28140445
The GGAs promote ARF-dependent recruitment of clathrin to the TGNQ28212201
COPI complex is a regulator of lipid homeostasisQ28474150
En bloc incorporation of coatomer subunits during the assembly of COP-coated vesiclesQ28609807
Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesiclesQ28609809
The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?Q29618125
Phosphatidylserine flipping enhances membrane curvature and negative charge required for vesicular transport.Q30544961
Mutational analysis of betaCOP (Sec26p) identifies an appendage domain critical for functionQ33315718
A primer on vesicle buddingQ33603151
Arf GAPs: gatekeepers of vesicle generationQ33886676
New COP1-binding motifs involved in ER retrievalQ33890112
Activity of specific lipid-regulated ADP ribosylation factor-GTPase-activating proteins is required for Sec14p-dependent Golgi secretory function in yeastQ33893326
Inter-Golgi transport mediated by COPI-containing vesicles carrying small cargoes.Q34378543
Dynamic assembly of the exomer secretory vesicle cargo adaptor subunitsQ34507970
The Erv41-Erv46 complex serves as a retrograde receptor to retrieve escaped ER proteinsQ34983654
Deletion of yeast p24 genes activates the unfolded protein responseQ35583739
Arf GAPs: multifunctional proteins that regulate membrane traffic and actin remodellingQ35622152
Rapid and reproducible single-stage phosphopeptide enrichment of complex peptide mixtures: application to general and phosphotyrosine-specific phosphoproteomics experimentsQ35650675
Heterotrimer-independent regulation of activation-loop phosphorylation of Snf1 protein kinase involves two protein phosphatasesQ36001396
Structural basis for the binding of tryptophan-based motifs by δ-COP.Q36306048
Two human ARFGAPs associated with COP-I-coated vesicles.Q36320232
ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation.Q36321109
The Gcs1 and Age2 ArfGAP proteins provide overlapping essential function for transport from the yeast trans-Golgi networkQ36381394
Arf GAPs and membrane trafficQ36428818
The yeast p24 complex is required for the formation of COPI retrograde transport vesicles from the Golgi apparatus.Q36492026
δ-COP contains a helix C-terminal to its longin domain key to COPI dynamics and functionQ37040816
Discrete determinants in ArfGAP2/3 conferring Golgi localization and regulation by the COPI coatQ37078657
Arf GAP2 is positively regulated by coatomer and cargoQ37217544
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue16
P577publication date2019-08-29
P1433published inJournal of Cell ScienceQ1524177
P859sponsorCollaborative Research Centre 1190: Compartmental Gates and Contact Sites in CellsQ48905361
P1476titleDissection of GTPase-activating proteins reveals functional asymmetry in the COPI coat of budding yeast
P478volume132

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