Impact of Myeloid Reservoirs in HIV Cure Trials

scientific article published on 01 April 2019

Impact of Myeloid Reservoirs in HIV Cure Trials is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S11904-019-00438-5
P932PMC publication ID6589351
P698PubMed publication ID30835045

P50authorLishomwa NdhlovuQ74388390
P2093author name stringBrooks I Mitchell
Elizabeth I Laws
P2860cites workRandomized Clinical Trial to Assess the Impact of the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01 on HIV-1 Persistence in Individuals on Effective ARTQ58585537
Combination therapy with anti-HIV-1 antibodies maintains viral suppressionQ59090059
Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individualsQ59351843
Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infectionQ59359146
Phenotypic and functional characterization of human T cell clonesQ69841334
Binding of neomycin to the TAR element of HIV-1 RNA induces dissociation of Tat protein by an allosteric mechanismQ74457489
Macrophage HIV-1 infection in duodenal tissue of patients on long term HAARTQ84229162
CCR2 on Peripheral Blood CD14+CD16+ Monocytes Correlates with Neuronal Damage, HIV-Associated Neurocognitive Disorders, and Peripheral HIV DNA: reseeding of CNS reservoirs?Q89451196
A quantitative approach for measuring the reservoir of latent HIV-1 provirusesQ91284113
HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapyQ91341307
Human immunodeficiency virus infection of human astrocytes disrupts blood-brain barrier integrity by a gap junction-dependent mechanismQ24594703
Gene transfer in humans using a conditionally replicating lentiviral vectorQ24675343
Designing and Interpreting Limiting Dilution Assays: General Principles and Applications to the Latent Reservoir for Human Immunodeficiency Virus-1Q26781918
HIV-1 eradication strategies: design and assessmentQ26864933
TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV InfectionQ27316403
Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV InfectionQ27317216
CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cellsQ27322949
Persistence of virus reservoirs in ART-treated SHIV-infected rhesus macaques after autologous hematopoietic stem cell transplantQ27323780
Semen CD4+ T cells and macrophages are productively infected at all stages of SIV infection in macaquesQ27331721
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapyQ28253761
The neuropathogenesis of AIDSQ28300983
Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humansQ28345408
Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapyQ28544949
Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantationQ29615068
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleasesQ29615069
Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapyQ29615992
Recovery of replication-competent HIV despite prolonged suppression of plasma viremiaQ29615995
Oligonucleotide inhibition of the interaction of HIV-1 Tat protein with the trans-activation responsive region (TAR) of HIV RNA.Q33178132
Bone-marrow-derived microglia: myth or reality?Q33335604
Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementiaQ33501775
Small alveolar macrophages are infected preferentially by HIV and exhibit impaired phagocytic functionQ33562292
HIV DNA in circulating monocytes as a mechanism to dementia and other HIV complicationsQ33805298
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection.Q34025414
HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostatQ34106191
Combination of biological screening in a cellular model of viral latency and virtual screening identifies novel compounds that reactivate HIV-1Q34132738
Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activityQ34204325
Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homologQ34284559
Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapyQ34290545
Macrophages and their relevance in Human Immunodeficiency Virus Type I infectionQ34303855
Absence of detectable HIV-1 viremia after treatment cessation in an infantQ34379777
Expansion of dysfunctional Tim-3-expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaquesQ34550643
Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assayQ34758220
Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcriptsQ35202038
The contribution of monocyte infection and trafficking to viral persistence, and maintenance of the viral reservoir in HIV infectionQ35213775
Ex vivo response to histone deacetylase (HDAC) inhibitors of the HIV long terminal repeat (LTR) derived from HIV-infected patients on antiretroviral therapy.Q35436367
Viremic relapse after HIV-1 remission in a perinatally infected childQ35633017
The Depsipeptide Romidepsin Reverses HIV-1 Latency In VivoQ35778783
The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from LatencyQ35829282
The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophagesQ35868086
Bryostatin activates HIV-1 latent expression in human astrocytes through a PKC and NF-ĸB-dependent mechanismQ35877276
A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected IndividualsQ36038655
Lysis of HIV-1-infected autologous CD4+ primary T cells by interferon-alpha-activated NK cells requires NKp46 and NKG2D.Q36064034
CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART.Q36077348
Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with PanobinostatQ36086345
Nef Is Dispensable for Resistance of Simian Immunodeficiency Virus-Infected Macrophages to CD8+ T Cell KillingQ36086379
CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirsQ36250079
Activation and lysis of human CD4 cells latently infected with HIV-1Q36250921
Preferential Destruction of Interstitial Macrophages over Alveolar Macrophages as a Cause of Pulmonary Disease in Simian Immunodeficiency Virus-Infected Rhesus MacaquesQ36260388
Reduced basal transcriptional activity of central nervous system-derived HIV type 1 long terminal repeatsQ36554035
Lysis of HIV-1-infected cells and inhibition of viral replication by universal receptor T cellsQ36598618
Macrophages sustain HIV replication in vivo independently of T cellsQ36737917
Targeting IκB proteins for HIV latency activation: the role of individual IκB and NF-κB proteinsQ36759698
Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantationQ36796554
The meningeal lymphatic system: a route for HIV brain migration?Q36906028
High levels of CD2 expression identify HIV-1 latently infected resting memory CD4+ T cells in virally suppressed subjects.Q37123276
Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation studyQ37413059
A pilot study assessing the safety and latency-reversing activity of disulfiram in HIV-1-infected adults on antiretroviral therapyQ37604524
A highly reproducible quantitative viral outgrowth assay for the measurement of the replication-competent latent HIV-1 reservoirQ37663180
New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.Q37695001
HIV-1 latency in monocytes/macrophagesQ38206643
Valproic acid perturbs hematopoietic homeostasis by inhibition of erythroid differentiation and activation of the myelo-monocytic pathwayQ38504203
Reversal of T-cell exhaustion as a strategy to improve immune control of HIV-1.Q38584018
Brain Microglial Cells Are Highly Susceptible to HIV-1 Infection and SpreadQ38795540
Clinical Trial of the Anti-PD-L1 Antibody BMS-936559 in HIV-1 Infected Participants on Suppressive Antiretroviral TherapyQ38826536
Toxicity and in vitro activity of HIV-1 latency-reversing agents in primary CNS cellsQ38924992
Evidence for human immunodeficiency virus type 1 replication in vivo in CD14(+) monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapyQ39685944
Pneumococcal capsular polysaccharide is immunogenic when present on the surface of macrophages and dendritic cells: TLR4 signaling induced by a conjugate vaccine or by lipopolysaccharide is conducive.Q40016407
Brain Macrophages in Simian Immunodeficiency Virus-Infected, Antiretroviral-Suppressed Macaques: a Functional Latent ReservoirQ40082046
HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapyQ40240401
Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node.Q40302209
Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapyQ40507703
PD-1(+) and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individualsQ40653907
Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected MacaquesQ40734962
Activation of latent human immunodeficiency virus by the histone deacetylase inhibitor panobinostat: a pilot study to assess effects on the central nervous systemQ40889762
Alpha E beta 7 and alpha 4 beta 7 integrins associated with intraepithelial and mucosal homing, are expressed on macrophagesQ41371628
Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjectsQ41750120
Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virusQ41914053
HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim.Q41921236
The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over timeQ41954397
Simian immunodeficiency virus infection of macaque bone marrow macrophages correlates with disease progression in vivoQ41981904
A CD3/CD28 microbead-based HIV-1 viral outgrowth assayQ42365535
In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a "Block-and-Lock" Strategy for HIV-1 Treatment.Q42381408
Macrophages are the major target cell for HIV infection in long-term marrow culture and demonstrate dual susceptibility to lymphocytotropic and monocytotropic strains of HIV-1.Q42628713
A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapyQ44165805
Histone deacetylase inhibitor valproic acid enhances the cytokine-induced expansion of human hematopoietic stem cells.Q45285591
HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study.Q45954015
Fc receptor but not complement binding is important in antibody protection against HIV.Q46545827
CD14 expression by activated parenchymal microglia/macrophages and infiltrating monocytes following human traumatic brain injuryQ48605136
Monocytes harbour replication-competent, non-latent HIV-1 in patients on highly active antiretroviral therapy.Q52021616
Clonal CD4+ T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation.Q52568482
Safety and Efficacy of PD-1 Inhibitors Among HIV-Positive Patients with Non-Small-Cell Lung Cancer.Q52598575
Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells expressing CD30.Q52731001
CD89-mediated recruitment of macrophages via a bispecific antibody enhances anti-tumor efficacy.Q52731744
Resistance of HIV-infected macrophages to CD8+ T lymphocyte-mediated killing drives activation of the immune system.Q53693959
CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells.Q53822439
Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1-infected individualsQ57042022
Improved assays to measure and characterize the inducible HIV reservoirQ57477977
The CD16+ Monocyte Subset Is More Permissive to Infection and Preferentially Harbors HIV-1 In VivoQ58003915
P433issue2
P304page(s)129-140
P577publication date2019-04-01
P1433published inCurrent HIV/AIDS reportsQ26842190
P1476titleImpact of Myeloid Reservoirs in HIV Cure Trials
P478volume16