Ethyl pyruvate attenuates ventilation-induced diaphragm dysfunction through high-mobility group box-1 in a murine endotoxaemia model

scientific article published on 10 June 2019

Ethyl pyruvate attenuates ventilation-induced diaphragm dysfunction through high-mobility group box-1 in a murine endotoxaemia model is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/JCMM.14478
P932PMC publication ID6652995
P698PubMed publication ID31339670

P50authorLi-Fu LiQ92145859
P2093author name stringNing-Hung Chen
Chih-Hao Chang
Shih-Wei Lin
Han-Chung Hu
Gwo-Jyh Chang
Kuo-Chin Kao
Yung-Yang Liu
P2860cites workOxidative stress-mediated HMGB1 biologyQ27000955
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytesQ28574795
Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant productionQ34003272
Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammationQ34156078
Toll-like receptor 4 mediates lipopolysaccharide-induced muscle catabolism via coordinate activation of ubiquitin-proteasome and autophagy-lysosome pathwaysQ34421809
Autophagy and skeletal muscles in sepsisQ34442945
Current Murine Models of Sepsis.Q34531020
Mechanical ventilation enhances HMGB1 expression in an LPS-induced lung injury modelQ34994835
Beneficial effects of ethyl pyruvate through inhibiting high-mobility group box 1 expression and TLR4/NF-κB pathway after traumatic brain injury in the rat.Q35104577
Intrinsic apoptosis in mechanically ventilated human diaphragm: linkage to a novel Fos/FoxO1/Stat3-Bim axis.Q35169490
Intranasal delivery of HMGB1 siRNA confers target gene knockdown and robust neuroprotection in the postischemic brain.Q35876200
Ethyl pyruvate induces heme oxygenase-1 through p38 mitogen-activated protein kinase activation by depletion of glutathione in RAW 264.7 cells and improves survival in septic animalsQ36084464
Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by suppression of HMGB1/RAGE/NF-ΚB pathwayQ36632317
High-molecular-weight hyaluronan--a possible new treatment for sepsis-induced lung injury: a preclinical study in mechanically ventilated ratsQ36955265
Ethyl pyruvateQ37149819
Patterns of diaphragm function in critically ill patients receiving prolonged mechanical ventilation: a prospective longitudinal studyQ37153270
Nuclear factor-κB signaling contributes to mechanical ventilation-induced diaphragm weakness*Q37205760
Diaphragm weakness in mechanically ventilated critically ill patientsQ37343222
JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocationQ37612678
Reactive oxygen species are signalling molecules for skeletal muscle adaptation.Q37625565
HMGB1, a potent proinflammatory cytokine in sepsisQ37720063
High-mobility group box 1, oxidative stress, and diseaseQ37802381
Ventilator-induced diaphragm dysfunction: cause and effectQ38120655
TLR4 as receptor for HMGB1 induced muscle dysfunction in myositis.Q39520949
Ethyl pyruvate inhibits the acetylation and release of HMGB1 via effects on SIRT1/STAT signaling in LPS-activated RAW264.7 cells and peritoneal macrophagesQ40444430
Beneficial effects of dantrolene on sepsis-induced diaphragmatic dysfunction are associated with downregulation of high-mobility group box 1 and calpain-caspase-3 proteolytic pathwayQ40935099
Diaphragmatic dysfunction in patients with ICU-acquired weakness and its impact on extubation failureQ41120892
Effects of controlled mechanical ventilation on sepsis-induced diaphragm dysfunction in ratsQ41658784
Early administration of cisatracurium attenuates sepsis-induced diaphragm dysfunction in ratsQ41722381
Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model.Q42062324
A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting.Q42085122
Muscle-specific inhibition of the classical nuclear factor-κB pathway is protective against diaphragmatic weakness in murine endotoxemiaQ42460720
Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shockQ44028476
Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged miceQ44609782
Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathiesQ44755630
Diaphragm muscle atrophy in the mouse after long-term mechanical ventilationQ45841526
Neutralization of receptor for advanced glycation end-products and high mobility group box-1 attenuates septic diaphragm dysfunction in rats with peritonitis.Q45923637
Crosstalk between autophagy and oxidative stress regulates proteolysis in the diaphragm during mechanical ventilation.Q46249490
A phase II multicenter double-blind placebo-controlled study of ethyl pyruvate in high-risk patients undergoing cardiac surgery with cardiopulmonary bypassQ46331601
The effect of ethyl pyruvate on dapsone-induced methemoglobinemia in ratsQ46343749
Ethyl pyruvate decreased early nuclear factor-kappaB levels but worsened survival in lipopolysaccharide-challenged mice.Q46822297
Critical illness-associated diaphragm weaknessQ47771152
Contributions of high mobility group box protein in experimental and clinical acute lung injury.Q47925618
Diaphragm dysfunction on admission to the intensive care unit. Prevalence, risk factors, and prognostic impact-a prospective study.Q48011546
Ethyl pyruvate reduces ventilation-induced neutrophil infiltration and oxidative stressQ50245257
Mechanical ventilation-induced oxidative stress in the diaphragm.Q51296490
Relationship between Autophagy and Ventilator-induced Diaphragmatic Dysfunction.Q51305465
Mechanical ventilation triggers abnormal mitochondrial dynamics and morphology in the diaphragm.Q51650396
Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity.Q55437419
Degradation of histone deacetylase 4 via the TLR4/JAK/STAT1 signaling pathway promotes the acetylation of high mobility group box 1 (HMGB1) in lipopolysaccharide‐activated macrophages.Q55516381
Activation of gene expression in human neutrophils by high mobility group box 1 proteinQ73087842
HMG-1 as a mediator of acute lung inflammationQ74279708
Pulmonary levels of high-mobility group box 1 during mechanical ventilation and ventilator-associated pneumoniaQ80883024
Contribution of high-mobility group box-1 to the development of ventilator-induced lung injuryQ83854620
Preliminary safety and biological efficacy studies of ethyl pyruvate in normal mature horsesQ83861637
Toll-like receptor 4 signaling in ventilator-induced diaphragm atrophyQ84433305
Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humansQ84976710
The Signaling Network Resulting in Ventilator-induced Diaphragm DysfunctionQ88693037
Attenuation of ventilation-induced diaphragm dysfunction through toll-like receptor 4 and nuclear factor-κB in a murine endotoxemia modelQ89170925
Diaphragm Weakness in the Critically Ill: Basic Mechanisms Reveal Therapeutic OpportunitiesQ91137752
P433issue8
P304page(s)5679-5691
P577publication date2019-06-10
P1433published inJournal of Cellular and Molecular MedicineQ1524063
P1476titleEthyl pyruvate attenuates ventilation-induced diaphragm dysfunction through high-mobility group box-1 in a murine endotoxaemia model
P478volume23

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