Organ Dysfunction in Sepsis: An Ominous Trajectory From Infection To Death

scientific article published on 20 December 2019

Organ Dysfunction in Sepsis: An Ominous Trajectory From Infection To Death is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P932PMC publication ID6913810
P698PubMed publication ID31866778

P2093author name stringFabián Jaimes
César Caraballo
P2860cites workComparison of Dopamine and Norepinephrine in the Treatment of ShockQ22250880
Fluid Resuscitation in SepsisQ22305304
Epidemiology of severe sepsisQ22305425
Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortalityQ24621520
The microcirculation is the motor of sepsisQ24633735
Comparison of the accuracy of three early warning scores with SOFA score for predicting mortality in adult sepsis and septic shock patients admitted to intensive care unitQ92560554
Epidemiology of disseminated intravascular coagulation in sepsis and validation of scoring systemsQ93341013
Bench-to-bedside review: Cytopathic hypoxiaQ24807180
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)Q26768286
Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)Q26768292
The coagulopathy of acute sepsisQ26826950
The role of the liver in sepsisQ26864861
Severe sepsis and septic shockQ27026614
Hypoxic Hepatitis: A Review and Clinical UpdateQ28078274
The ability of the National Early Warning Score (NEWS) to discriminate patients at risk of early cardiac arrest, unanticipated intensive care unit admission, and deathQ28282816
Acute respiratory distress syndrome: the Berlin DefinitionQ29615138
Incidence and outcomes of acute lung injuryQ29615139
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions ConferenceQ29618757
The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care MedicineQ29618869
Acute kidney injury in sepsis.Q30235009
Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-AnalysisQ30572421
The encephalopathy in sepsisQ31145115
The hematologic system as a marker of organ dysfunction in sepsisQ33348784
Thrombocytopenia in septic shock patients--a prospective observational study of incidence, risk factors and correlation with clinical outcomeQ33377823
Epidemiology and prognostic factors in severe sepsis/septic shock. Evolution over six yearsQ33420945
Thrombocytopenia in adult patients with sepsis: incidence, risk factors, and its association with clinical outcomeQ33421465
Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).Q33692899
Pattern of brain injury in the acute setting of human septic shockQ33753392
Clinical characteristics and outcomes of sepsis-related vs non-sepsis-related ARDS.Q34130693
Simplified severe sepsis protocol: a randomized controlled trial of modified early goal-directed therapy in ZambiaQ34353258
Long-term outcomes following development of new-onset atrial fibrillation during sepsisQ34448321
Cognitive decline after sepsisQ34450127
Association between intravenous chloride load during resuscitation and in-hospital mortality among patients with SIRSQ34553590
Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activationQ34744890
Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shockQ35621102
Prognostic significance of the angiopoietin-2/angiopoietin-1 and angiopoietin-1/Tie-2 ratios for early sepsis in an emergency departmentQ36159586
Balanced Crystalloids versus Saline in the Intensive Care Unit. The SALT Randomized TrialQ39282707
Occult hypoperfusion and mortality in patients with suspected infectionQ39804211
Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014.Q40048733
Prognostic impact of isolated right ventricular dysfunction in sepsis and septic shock: an 8-year historical cohort studyQ40051663
Recognizing Sepsis as a Global Health Priority - A WHO ResolutionQ40154811
Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and LimitationsQ40491993
Quick Sepsis-related Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and Early Warning Scores for Detecting Clinical Deterioration in Infected Patients outside the Intensive Care UnitQ40533921
Understanding circulatory failure in sepsis.Q40543074
Site of infection and mortality in patients with severe sepsis or septic shock. A cohort study of patients admitted to a Danish general intensive care unitQ40621516
Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytesQ40667140
Longitudinal Study of the Effects of Bacteremia and Sepsis on 5-year Risk of Cardiovascular Events.Q40668939
Infection site is predictive of outcome in acute lung injury associated with severe sepsis and septic shockQ40735734
Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year studyQ41719170
Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension: A Randomized Clinical Trial.Q41925460
Sepsis-Induced Cardiomyopathy: Mechanisms and TreatmentsQ42362538
Systemic infection and delirium: when cytokines and acetylcholine collideQ43147571
Histopathology of septic shock induced acute kidney injury: apoptosis and leukocytic infiltrationQ43238982
Proinflammatory cytokines inhibit secretion in rat bile duct epithelium.Q43662711
A prospective analysis of disseminated intravascular coagulation in patients with infectionsQ44033357
Association between mitochondrial dysfunction and severity and outcome of septic shockQ44074137
Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsisQ44460646
Serum lactate is associated with mortality in severe sepsis independent of organ failure and shockQ46072670
Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement programQ46444641
Myocardial Injury in Patients With Sepsis and Its Association With Long-Term OutcomeQ47555255
Epidemiology, causes, evolution and outcome in a single-center cohort of 1116 critically ill patients with hypoxic hepatitis.Q47643144
Angiopoietins: a link between angiogenesis and inflammation.Q36625591
Vasopressin: mechanisms of action on the vasculature in health and in septic shockQ36667777
Mechanisms of sepsis-induced cardiac dysfunctionQ36799073
New paradigms in sepsis: from prevention to protection of failing microcirculationQ37238202
Evaluation of SOFA-based models for predicting mortality in the ICU: A systematic reviewQ37353227
Vascular hyporesponsiveness to vasopressors in septic shock: from bench to bedsideQ37791460
Sepsis-associated encephalopathyQ38044198
Clinical review: The liver in sepsisQ38058384
Thrombomodulin in sepsisQ38067550
Vasoplegia in septic shock: do we really fight the right enemy?Q38149625
Correlation of left ventricular systolic dysfunction determined by low ejection fraction and 30-day mortality in patients with severe sepsis and septic shock: a systematic review and meta-analysisQ38205576
New directions for sepsis and septic shock researchQ38321867
Hydrocortisone treatment in early sepsis-associated acute respiratory distress syndrome: results of a randomized controlled trialQ38386593
Diastolic dysfunction and mortality in septic patients: a systematic review and meta-analysis.Q38387924
Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 CountriesQ38395601
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.Q38433744
The Economic and Humanistic Burden of Severe SepsisQ38455028
Cholestatic liver (dys)function during sepsis and other critical illnessesQ38590747
Cardiovascular dysfunction in sepsis at the dawn of emerging mediatorsQ38608262
A rational approach to fluid therapy in sepsisQ38617704
Heart rate variability as predictor of mortality in sepsis: A prospective cohort studyQ38706837
Neurology of SepsisQ38714969
Risk of Acute Coronary Heart Disease After Sepsis Hospitalization in the REasons for Geographic and Racial Differences in Stroke CohortQ38736141
SOFA and mortality endpoints in randomized controlled trials: a systematic review and meta-regression analysisQ38753960
Cardiac hyporesponsiveness in severe sepsis is associated with nitric oxide-dependent activation of G protein receptor kinase.Q38773781
Microcirculatory dysfunction in sepsis: pathophysiology, clinical monitoring, and potential therapiesQ38815302
Mortality after fluid bolus in African children with severe infectionQ38870112
Mechanical Ventilation in Sepsis: A Reappraisal.Q38907563
Risk of Acute Stroke After Hospitalization for Sepsis: A Case-Crossover StudyQ38961607
Conservative fluid management or deresuscitation for patients with sepsis or acute respiratory distress syndrome following the resuscitation phase of critical illness: a systematic review and meta-analysisQ38979212
Prognostic Accuracy of the SOFA Score, SIRS Criteria, and qSOFA Score for In-Hospital Mortality Among Adults With Suspected Infection Admitted to the Intensive Care UnitQ39004033
Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice.Q39028464
Liver - guardian, modifier and target of sepsisQ39031051
Hemodynamic coherence in sepsis.Q39033282
Impact of thrombosis on pulmonary endothelial injury and repair following sepsisQ39107051
Acute kidney injury in patients with severe sepsis in Finnish Intensive Care UnitsQ48004171
The neuropathology of septic shock.Q48007037
Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shockQ48126570
Vasoplegia in patients with sepsis and septic shock: pathways and mechanismsQ48247612
Severe sepsis and cardiac arrhythmiasQ48505769
Association of Clinical Hypoperfusion Variables with Lactate Clearance and Hospital MortalityQ50067503
Sepsis in Older AdultsQ50099650
Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy.Q51670034
Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial.Q51683065
Balanced Crystalloids versus Saline in Noncritically Ill Adults.Q52683172
Balanced Crystalloids versus Saline in Critically Ill Adults.Q52683174
qSOFA, SIRS and NEWS for predicting inhospital mortality and ICU admission in emergency admissions treated as sepsis.Q52691672
Acute Respiratory Distress Syndrome: Advances in Diagnosis and Treatment.Q52691987
Improving the Accuracy of Cardiovascular Component of the Sequential Organ Failure Assessment Score.Q53288934
Sepsis in European intensive care units: results of the SOAP study.Q54471944
Predictors of response to fixed-dose vasopressin in adult patients with septic shock.Q54956950
Drotrecogin alfa (activated) in adults with septic shock.Q55056165
Progression into sepsis: an individualized process varying by the interaction of comorbidities with the underlying infection.Q55432715
The global burden of sepsis: barriers and potential solutionsQ56909229
The role of biomarkers of endothelial activation in predicting morbidity and mortality in patients with severe sepsis and septic shock in intensive care: A prospective observational studyQ57489142
Heart rate variability as predictor of mortality in sepsis: A systematic reviewQ58752263
Acute Renal Failure in Critically Ill Patients A Multinational, Multicenter StudyQ61363260
Septic Acute Kidney Injury in Critically Ill Patients: Clinical Characteristics and OutcomesQ61661940
Timing of administration of epinephrine predicts the responsiveness to epinephrine in norepinephrine-refractory septic shock: a retrospective studyQ64072823
Prognostic accuracy of the serum lactate level, the SOFA score and the qSOFA score for mortality among adults with SepsisQ64080339
Neutrophils disturb pulmonary microcirculation in sepsis-induced acute lung injuryQ64106613
Broad spectrum vasopressors: a new approach to the initial management of septic shock?Q64107671
Cardiovascular determinants of resuscitation from sepsis and septic shockQ64112965
Current use of vasopressors in septic shockQ64126327
Association between site of infection and in-hospital mortality in patients with sepsis admitted to emergency departments of tertiary hospitals in Medellin, ColombiaQ64289260
American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsisQ68141412
Validation of a modified Early Warning Score in medical admissionsQ74596079
EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care unitsQ76401271
Septic shock: a heart story since the 1960sQ82997240
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shockQ83177700
Unfractioned heparin for treatment of sepsis: A randomized clinical trial (The HETRASE Study)Q83395033
The acute respiratory distress syndromeQ84693193
KDIGO clinical practice guidelines for acute kidney injuryQ84789239
Thrombocytopenia: A Risk Factor of Mortality for Patients with Sepsis in the Intensive Care UnitQ87695938
Sepsis-induced acute kidney injury: A disease of the microcirculationQ89122454
Fluid Management in SepsisQ89478278
Sepsis associated acute kidney injuryQ90969155
Development and Evaluation of a Machine Learning Model for the Early Identification of Patients at Risk for SepsisQ91129680
Antibiotics has more impact on mortality than other early goal-directed therapy components in patients with sepsis: An instrumental variable analysisQ91463328
Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical TrialQ91652838
Cardiovascular Events and Hospital Deaths Among Patients With Severe SepsisQ91655230
How we manage haemostasis during sepsisQ92091384
Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical TrialQ92138282
Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for SepsisQ92138291
Risk Factors for Stroke in Patients With Sepsis and Bloodstream InfectionsQ92522151
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P433issue4
P921main subjectsepsisQ183134
multiple organ dysfunction syndromeQ1193870
P304page(s)629-640
P577publication date2019-12-01
2019-12-20
P1433published inYale Journal of Biology and MedicineQ15709982
P1476titleOrgan Dysfunction in Sepsis: An Ominous Trajectory From Infection To Death
P478volume92

Search more.