MicroRNA-140-5p inhibits cell proliferation, migration and promotes cell apoptosis in gastric cancer through the negative regulation of THY1-mediated Notch signaling

scientific article published on 23 July 2019

MicroRNA-140-5p inhibits cell proliferation, migration and promotes cell apoptosis in gastric cancer through the negative regulation of THY1-mediated Notch signaling is …
instance of (P31):
scholarly articleQ13442814
retracted paperQ45182324

External links are
P356DOI10.1042/BSR20181434
P932PMC publication ID6646234
P698PubMed publication ID31123165

P50authorZhi-Gang JieQ92255184
P2093author name stringJun Zou
Chao Lin
Kun Wu
P2860cites workmiRNAs in human cancerQ24628889
Role of Notch signaling pathway in gastric cancer: a meta-analysis of the literatureQ26830624
Thy-1 as a regulator of cell-cell and cell-matrix interactions in axon regeneration, apoptosis, adhesion, migration, cancer, and fibrosisQ28245613
Notch signaling in human development and diseaseQ28258962
A molecular signature of metastasis in primary solid tumorsQ29614442
Cancer metastasis: building a frameworkQ29616783
Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancerQ33688617
miRNA-223 Promotes Gastric Cancer Invasion and Metastasis by Targeting Tumor Suppressor EPB41L3Q34188647
MicroRNA-140 acts as a liver tumor suppressor by controlling NF-κB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression.Q34294469
Notch signaling proteins: legitimate targets for cancer therapyQ34982347
Thy-1, a versatile modulator of signaling affecting cellular adhesion, proliferation, survival, and cytokine/growth factor responsesQ35610005
RhoA-Mediated Signaling in Notch-Induced Senescence-Like Growth Arrest and Endothelial Barrier DysfunctionQ35657354
Silencing Notch-1 induces apoptosis and increases the chemosensitivity of prostate cancer cells to docetaxel through Bcl-2 and BaxQ35995318
Validity and Necessity of Sub-classification of N3 in the 7thUICC TNM Stage of Gastric CancerQ50853950
Long noncoding RNA UCA1 modulates breast cancer cell growth and apoptosis through decreasing tumor suppressive miR-143.Q52911989
A cumulative effect involving malfunction of the PTH1R and ATP4A genes explains a familial gastric neuroendocrine tumor with hypothyroidism and arthritisQ61937452
Molecular Definition of Interstitial Deletions of Chromosome 13 in Leukemic CellsQ68330915
[Expression and significance of Notch1 and PTEN in gastric cancer]Q81572347
Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancerQ36281632
Estrogen receptor α signaling regulates breast tumor-initiating cells by down-regulating miR-140 which targets the transcription factor SOX2.Q36436148
Deciphering the Palimpsest: Studying the Relationship Between Morphological Integration and Phenotypic CovariationQ36510806
Novel functions for small RNA moleculesQ36673371
MicroRNA-140 Inhibits Cell Proliferation in Gastric Cancer Cell Line HGC-27 by Suppressing SOX4.Q37058892
Cancer stem cell marker CD90 inhibits ovarian cancer formation via β3 integrinQ37337887
Downregulation of miR-140 promotes cancer stem cell formation in basal-like early stage breast cancerQ37445516
microRNA -140-5p inhibits colorectal cancer invasion and metastasis by targeting ADAMTS5 and IGFBP5.Q37466124
Comparison of the prognostic values of the 2010 WHO classification, AJCC 7th edition, and ENETS classification of gastric neuroendocrine tumorsQ37605547
Targeting notch signaling pathway in cancer: clinical development advances and challengesQ37696748
Regulation of epithelial–mesenchymal and mesenchymal–epithelial transitions by microRNAsQ38083976
Management of gastric cancer in Asia: resource-stratified guidelinesQ38157342
Role of epithelial mesenchymal transition in prostate tumorigenesisQ38288544
Apatinib: A novel receptor tyrosine kinase inhibitor for the treatment of gastric cancer.Q38707209
Septin 2 accelerates the progression of biliary tract cancer and is negatively regulated by mir-140-5pQ38772550
MicroR-140-5p suppresses tumor cell migration and invasion by targeting ADAM10-mediated Notch1 signaling pathway in hypopharyngeal squamous cell carcinomaQ38809088
MicroRNA-140-5p inhibits the progression of colorectal cancer by targeting VEGFA.Q38832865
CD90 is upregulated in gastric cancer tissues and inhibits gastric cancer cell apoptosis by modulating the expression level of SPARC proteinQ38838892
Down-regulation of miR-140 induces EMT and promotes invasion by targeting Slug in esophageal cancerQ38947238
MicroRNA-140-5p suppresses tumor growth and metastasis by targeting transforming growth factor β receptor 1 and fibroblast growth factor 9 in hepatocellular carcinomaQ39196206
Aggregation of integrins and RhoA activation are required for Thy-1-induced morphological changes in astrocytesQ40541176
miR-485-5p acts as a negative regulator in gastric cancer progression by targeting flotillin-1.Q41428675
miR-140-5p suppresses the proliferation, migration and invasion of gastric cancer by regulating YES1.Q41451321
Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cellsQ42009448
Role of Notch signaling pathway in gastric cancer pathogenesisQ42161527
Molecular mechanism for the inhibitory action of interferon on hematopoiesisQ43507410
A CD90(+) tumor-initiating cell population with an aggressive signature and metastatic capacity in esophageal cancer.Q44459847
Increased survival associated with surgery and radiation therapy in metastatic gastric cancer: a Surveillance, Epidemiology, and End Results database analysisQ45327893
Targeting Notch signaling with a Notch2/Notch3 antagonist (tarextumab) inhibits tumor growth and decreases tumor-initiating cell frequencyQ46174937
In vivo and in vitro effects of microRNA-124 on human gastric cancer by targeting JAG1 through the Notch signaling pathway.Q47755401
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
CytoscapeQ3699942
limmaQ112236343
P433issue7
P921main subjectmicroRNAQ310899
P577publication date2019-07-23
P1433published inBioscience ReportsQ2790714
P1476titleMicroRNA-140-5p inhibits cell proliferation, migration and promotes cell apoptosis in gastric cancer through the negative regulation of THY1-mediated Notch signaling
P478volume39

Reverse relations

cites work (P2860)
Q92233218Identification and expression analysis of microRNAs in tibial growth plate of chicken through thiram toxicity
Q99242322Inhibition of ssc-microRNA-140-5p ameliorates the Clostridium perfringens beta2 toxin-induced inflammatory response in IPEC-J2 cells via the ERK1/2 and JNK pathways by targeting VEGFA
Q89939847Long Non-Coding RNA TMPO-AS1 Promotes Cell Migration and Invasion by Sponging miR-140-5p and Inducing SOX4-Mediated EMT in Gastric Cancer
Q99624395MiR-140 Represses Esophageal Cancer Progression via Targeting ZEB2 to Regulate Wnt/β-Catenin Pathway
Q91145420MiR-6838-5p suppresses cell metastasis and the EMT process in triple-negative breast cancer by targeting WNT3A to inhibit the Wnt pathway
Q91426976MicroRNA-140-5p inhibits salivary adenoid cystic carcinoma progression and metastasis via targeting survivin
Q90352055NOTCH signaling pathway and non-coding RNAs in cancer
Q94663870The multiple roles of Thy-1 in cell differentiation and regeneration
Q110659602miR-140-5p Attenuates Hypoxia-Induced Breast Cancer Progression by Targeting Nrf2/HO-1 Axis in a Keap1-Independent Mechanism
Q92677013miR-449c-5p availability is antagonized by circ-NOTCH1 for MYC-induced NOTCH1 upregulation as well as tumor metastasis and stemness in gastric cancer

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