New WHO guidelines for treatment of gambiense human African trypanosomiasis including fexinidazole: substantial changes for clinical practice

scientific article published on 23 December 2019

New WHO guidelines for treatment of gambiense human African trypanosomiasis including fexinidazole: substantial changes for clinical practice is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/S1473-3099(19)30612-7
P698PubMed publication ID31879061

P50authorVeerle LejonQ51760266
François ChappuisQ28817156
P2093author name stringElie A Akl
Michael P Barrett
Gerardo Priotto
Jose Ramon Franco
Hanna Bergman
Gemma Villanueva
Andreas K Lindner
Pere Simarro
Olema Erphas
Jorge Seixas
Leon Kazumba
Erick Mwamba
Augustin Kadima Ebeja
P2860cites workClinical aspects of 2541 patients with second stage human African trypanosomiasisQ38912264
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GRADE guidelines: 14. Going from evidence to recommendations: the significance and presentation of recommendationsQ45412715
Clinical presentation and treatment outcome of sleeping sickness in Sudanese pre-school childrenQ46419741
Stage determination and therapeutic decision in human African trypanosomiasis: value of polymerase chain reaction and immunoglobulin M quantification on the cerebrospinal fluid of sleeping sickness patients in Côte d'Ivoire.Q46820909
Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trialQ47637613
Oral fexinidazole for human African trypanosomiasisQ49896872
How to shorten patient follow-up after treatment for Trypanosoma brucei gambiense sleeping sickness.Q51760220
Where there is no brain imaging: Safety and diagnostic value of lumbar puncture in patients with neurological disorders in a rural hospital of Central AfricaQ56886534
Monitoring the elimination of human African trypanosomiasis: Update to 2016Q60046224
Improving the quality of WHO guidelines over the last decade: progress and challengesQ88772538
The European Medicines Agency's scientific opinion on oral fexinidazole for human African trypanosomiasisQ93075160
How patients take malaria treatment: a systematic review of the literature on adherence to antimalarial drugsQ26823483
Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trialQ28250035
A molecular mechanism for eflornithine resistance in African trypanosomesQ28476349
Should I get screened for sleeping sickness? A qualitative study in Kasai province, Democratic Republic of CongoQ28478935
Adherence to artemisinin-based combination therapy for the treatment of malaria: a systematic review of the evidenceQ28538749
Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical TrialQ28550204
Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical StudiesQ28550224
GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tablesQ29547885
GRADE guidelines: 3. Rating the quality of evidenceQ29547891
GRADE guidelines: 4. Rating the quality of evidence--study limitations (risk of bias)Q29619791
Determination of an optimal dosing regimen for fexinidazole, a novel oral drug for the treatment of human African trypanosomiasis: first-in-human studiesQ33681753
Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness).Q34319076
From health advice to taboo: community perspectives on the treatment of sleeping sickness in the Democratic Republic of Congo, a qualitative studyQ35345427
Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sicknessQ35598430
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomesQ36516224
Treatment options for second-stage gambiense human African trypanosomiasisQ36551049
Treatment outcomes and risk factors for relapse in patients with early-stage human African trypanosomiasis (HAT) in the Republic of the CongoQ37063849
Intervention to promote patients' adherence to antimalarial medication: a systematic review.Q37456044
Nitroheterocyclic drug resistance mechanisms in Trypanosoma bruceiQ38270529
Adherence to Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria: A Systematic Review and Meta-AnalysisQ38544762
P433issue2
P921main subjectAfrican trypanosomiasisQ203133
P304page(s)e38-e46
P577publication date2019-12-23
P1433published inLancet Infectious DiseasesQ15724248
P1476titleNew WHO guidelines for treatment of gambiense human African trypanosomiasis including fexinidazole: substantial changes for clinical practice
P478volume20

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cites work (P2860)
Q89860236New Drugs for Human African Trypanosomiasis: A Twenty First Century Success Story
Q96610549Peptidyl Vinyl Ketones Irreversible Inhibitors of Rhodesain: Modifications of the P2 Fragment

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