Immunotherapies and Targeted Therapies in the Treatment of Metastatic Colorectal Cancer

scientific article published on 30 July 2019

Immunotherapies and Targeted Therapies in the Treatment of Metastatic Colorectal Cancer is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.3390/MEDSCI7080083
P932PMC publication ID6723550
P698PubMed publication ID31366129

P50authorPrashanth RawlaQ57002933
Andreas V HadjinicolaouQ90333939
P2093author name stringAdam Barsouk
Alexander Barsouk
P2860cites workOngoing and future directions in the management of metastatic colorectal cancer: Update on clinical trialsQ92249245
Revisiting immune escape in colorectal cancer in the era of immunotherapyQ92311646
Targeted antibody and cytokine cancer immunotherapies through collagen affinityQ93010833
The fms-like tyrosine kinase, a receptor for vascular endothelial growth factorQ24328901
Safety, activity, and immune correlates of anti-PD-1 antibody in cancerQ24633070
Dendritic cell-based cancer immunotherapy for colorectal cancerQ26751339
Peptide Vaccine Therapy in Colorectal CancerQ26830336
Value of bevacizumab in treatment of colorectal cancer: A meta-analysisQ26849789
Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor.Q27824811
Cetuximab for the treatment of colorectal cancer.Q27851419
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysisQ27851573
Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trialQ27853380
A genetic model for colorectal tumorigenesisQ27860582
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancerQ27860681
Immunity, Inflammation, and CancerQ27861048
Randomized phase III trial results of panitumumab, a fully human anti-epidermal growth factor receptor monoclonal antibody, in metastatic colorectal cancerQ28248065
PD-1 Blockade in Tumors with Mismatch-Repair DeficiencyQ28262647
Systematic review of microsatellite instability and colorectal cancer prognosisQ28303189
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administrationQ28378001
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancerQ29616236
Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation statusQ29619648
Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME studyQ29619653
What Is the Evidence That Tumors Are Angiogenesis Dependent?Q29620029
Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trialQ29620127
Role of first-line anti-epidermal growth factor receptor therapy compared with anti-vascular endothelial growth factor therapy in advanced colorectal cancer: a meta-analysis of randomized clinical trialsQ41458113
SPIRITT: A Randomized, Multicenter, Phase II Study of Panitumumab with FOLFIRI and Bevacizumab with FOLFIRI as Second-Line Treatment in Patients with Unresectable Wild Type KRAS Metastatic Colorectal CancerQ41733204
Phase II trial of erlotinib and capecitabine for patients with previously untreated metastatic colorectal cancerQ46128012
Fluorouracil, leucovorin, and irinotecan plus cetuximab treatment and RAS mutations in colorectal cancerQ46233566
A phase II randomized multicenter trial of gefitinib plus FOLFIRI and FOLFIRI alone in patients with metastatic colorectal cancer.Q46454840
Phase II study of gefitinib, fluorouracil, leucovorin, and oxaliplatin therapy in previously treated patients with metastatic colorectal cancerQ46658474
EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancerQ46662707
A randomized, placebo-controlled phase 2 study of ganitumab or conatumumab in combination with FOLFIRI for second-line treatment of mutant KRAS metastatic colorectal cancerQ46699227
Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair-Deficient/Microsatellite Instability-High Metastatic Colorectal CancerQ49887005
Nivolumab plus ipilimumab in metastatic colorectal cancerQ50207714
Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study.Q50876217
DNA mismatch repair in cancer.Q52580154
Updates on immunotherapy for colorectal cancer.Q52643529
A broad-spectrum integrative design for cancer prevention and therapy: The challenge ahead.Q53384598
Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations.Q54960920
Targeting the human epidermal growth factor receptor 2 (HER2) oncogene in colorectal cancer.Q54962247
Elimination of established tumors with nanodisc-based combination chemoimmunotherapy.Q55044963
Maintenance treatment with the immunomodulator MGN1703, a Toll-like receptor 9 (TLR9) agonist, in patients with metastatic colorectal carcinoma and disease control after chemotherapy: a randomised, double-blind, placebo-controlled trial.Q30317446
Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future ratesQ30538531
Phase III study of fluorouracil, leucovorin, and levamisole in high-risk stage II and III colon cancer: final report of Intergroup 0089.Q33228030
Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancerQ33389767
Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges.Q33828559
Adjuvant active specific immunotherapy for stage II and III colon cancer with an autologous tumor cell vaccine: Eastern Cooperative Oncology Group Study E5283.Q33885727
Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trialQ33922925
Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapyQ34187436
FOLFOXIRI plus bevacizumab versus FOLFIRI plus bevacizumab as first-line treatment of patients with metastatic colorectal cancer: updated overall survival and molecular subgroup analyses of the open-label, phase 3 TRIBE study.Q34492429
Impact of EGFR expression on colorectal cancer patient prognosis and survivalQ34553435
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.Q34557699
Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C StudyQ34583973
Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study.Q34590731
Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimenQ34642136
Bevacizumab plus capecitabine versus capecitabine alone in elderly patients with previously untreated metastatic colorectal cancer (AVEX): an open-label, randomised phase 3 trialQ34656044
Final results from a randomized phase 3 study of FOLFIRI {+/-} panitumumab for second-line treatment of metastatic colorectal cancer.Q34658519
PEAK: a randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wild-type KRAS exon 2 metastatic colorQ34660907
FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trialQ34663697
Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, doublQ34669325
Mature Results of a Prospective Randomized Trial Comparing 5-Flourouracil with Leucovorin to 5-Flourouracil with Levamisole as Adjuvant Therapy of Stage II and III Colorectal Cancer- The Israel Cooperative Oncology Group (ICOG) StudyQ34751755
The microsatellite instable subset of colorectal cancer is a particularly good candidate for checkpoint blockade immunotherapyQ34970884
Panitumumab in patients with KRAS wild-type colorectal cancer after progression on cetuximabQ35705200
Phase I/II study of adjuvant immunotherapy with sentinel lymph node T lymphocytes in patients with colorectal cancerQ35968018
Epidermal growth factor receptor targeting in cancerQ36557269
A prospective randomised trial to study the role of levamisole and interferon alfa in an adjuvant therapy with 5-FU for stage III colon cancer.Q36616783
Anti-CD73 in cancer immunotherapy: awakening new opportunities.Q36709157
A randomized phase II study of immunization with dendritic cells modified with poxvectors encoding CEA and MUC1 compared with the same poxvectors plus GM-CSF for resected metastatic colorectal cancer.Q37266006
Bypass mechanisms of resistance to receptor tyrosine kinase inhibition in lung cancerQ37421439
Receptor Tyrosine Kinase Phosphorylation Pattern-Based Multidrug Combination Is an Effective Approach for Personalized Cancer TreatmentQ38755813
MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint BlockadeQ38788877
Metabolite and Microbiome Interplay in Cancer ImmunotherapyQ38800832
Global patterns and trends in colorectal cancer incidence and mortality.Q38915351
Efficiency of adjuvant active specific immunization with Newcastle disease virus modified tumor cells in colorectal cancer patients following resection of liver metastases: results of a prospective randomized trialQ39980841
Contrast enhanced MRI and intravital fluorescence microscopy indicate improved tumor microcirculation in highly vascularized melanomas upon short-term anti-VEGFR treatmentQ39993891
Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap.Q55046482
Efficacy and safety of apatinib in patients with previously treated metastatic colorectal cancer: a real-world retrospective study.Q55130826
Immunotherapy in colorectal cancer: for the select few or all?Q55333223
Bevacizumab in Combination With Oxaliplatin, Fluorouracil, and Leucovorin (FOLFOX4) for Previously Treated Metastatic Colorectal Cancer: Results From the Eastern Cooperative Oncology Group Study E3200Q56679480
Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS studyQ57152185
Current status of immunotherapy in metastatic colorectal cancerQ59350349
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countriesQ60142201
Every step of the way: integrins in cancer progression and metastasisQ60340345
Gut Microbiota and Cancer: From Pathogenesis to TherapyQ61806850
Active specific immunotherapy with a beta-human chorionic gonadotropin peptide vaccine in patients with metastatic colorectal cancer: antibody response is associated with improved survivalQ74453121
Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE)Q82294729
Phase III trial of cetuximab with continuous or intermittent fluorouracil, leucovorin, and oxaliplatin (Nordic FLOX) versus FLOX alone in first-line treatment of metastatic colorectal cancer: the NORDIC-VII studyQ83801480
Duration of Adjuvant Chemotherapy for Stage III Colon CancerQ88202109
Immunosuppressive enzymes in the tumor microenvironmentQ88731021
Genetic and epigenetic alterations of colorectal cancerQ90842099
Early modifications of circulating microRNAs levels in metastatic colorectal cancer patients treated with regorafenibQ91241914
The evolving landscape of biomarkers for checkpoint inhibitor immunotherapyQ91520697
Where We Stand With Immunotherapy in Colorectal Cancer: Deficient Mismatch Repair, Proficient Mismatch Repair, and Toxicity ManagementQ91546708
Immunotherapy of colorectal cancer: Challenges for therapeutic efficacyQ91951567
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P921main subjectmetastatic colon cancerQ108566365
colorectal cancerQ188874
immunotherapyQ1427096
P577publication date2019-07-30
P1433published inMedical SciencesQ27725458
P1476titleImmunotherapies and Targeted Therapies in the Treatment of Metastatic Colorectal Cancer
P478volume7

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cites work (P2860)
Q89597699A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer
Q92642710Long Non-Coding RNA (lncRNA) BMP/OP-Responsive Gene (BORG) Promotes Development of Chemoresistance of Colorectal Cancer Cells to Carboplatin
Q91805763STAT1 as a potential prognosis marker for poor outcomes of early stage colorectal cancer with microsatellite instability

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