Comparative review of drug-drug interactions with epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small-cell lung cancer

scientific article published on 09 July 2019

Comparative review of drug-drug interactions with epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small-cell lung cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2147/OTT.S194870
P932PMC publication ID6636179
P698PubMed publication ID31371986

P2093author name stringJun-Ling Li
Zi-Yi Xu
P2860cites workNetwork meta-analysis of erlotinib, gefitinib, afatinib and icotinib in patients with advanced non-small-cell lung cancer harboring EGFR mutationsQ21132357
A randomized, double-blind, phase III study comparing two doses of erlotinib for second-line treatment of current smokers with advanced non-small-cell lung cancer (CurrentS).Q47667888
Changes in gefitinib, erlotinib and osimertinib pharmacokinetics under various gastric pH levels following oral administration of omeprazole and vonoprazan in ratsQ47745480
Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): a randomised, double-blind phase 3 non-inferiority trialQ47773490
An evaluation of the possible interaction of gastric acid suppressing medication and the EGFR tyrosine kinase inhibitor erlotinibQ47872073
Significant drug interaction: phenytoin toxicity due to erlotinibQ48229241
First-SIGNAL: first-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lungQ48476437
Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes.Q48589806
Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases ActivityQ48615207
Exploring the relationship between expression of cytochrome P450 enzymes and gefitinib pharmacokineticsQ48695639
The Effect of Food or Omeprazole on the Pharmacokinetics of Osimertinib in Patients With Non-Small-Cell Lung Cancer and in Healthy Volunteers.Q49602341
Metabolic Pathway of Icotinib In Vitro: The Differential Roles of CYP3A4, CYP3A5, and CYP1A2 on Potential Pharmacokinetic Drug-Drug InteractionQ49786703
Systemic Therapy for Stage IV Non-Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update.Q51808302
Clinical pharmacokinetics of erlotinib in patients with solid tumors and exposure-safety relationship in patients with non-small cell lung cancerQ51936030
Effect of Sustained Elevated Gastric pH Levels on Gefitinib ExposureQ53519220
Comparative analysis of three drug-drug interaction screening systems against probable clinically relevant drug-drug interactions: a prospective cohort studyQ54261327
Population pharmacokinetics of afatinib, an irreversible ErbB family blocker, in patients with various solid tumorsQ54377793
The effect of rifampicin, a prototypical CYP3A4 inducer, on erlotinib pharmacokinetics in healthy subjectsQ54381356
The ERBB network: at last, cancer therapy meets systems biology.Q54498075
Afatinib pharmacokinetics and metabolism after oral administration to healthy male volunteersQ54540504
Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancerQ54587349
Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor ReceptorQ55022087
Clinical Impact of Gastric Acid-Suppressing Medication Use on the Efficacy of Erlotinib and Gefitinib in Patients With Advanced Non-Small-Cell Lung Cancer Harboring EGFR MutationsQ55027058
Development, Verification, and Prediction of Osimertinib Drug-Drug Interactions Using PBPK Modeling Approach to Inform Drug Label.Q55080883
Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upQ57051777
Adverse effect of anticonvulsants on efficacy of chemotherapy for acute lymphoblastic leukaemiaQ73171655
Phase I, pharmacokinetic, and biological study of erlotinib in combination with paclitaxel and carboplatin in patients with advanced solid tumorsQ79451540
Phase I trial of sorafenib in combination with gefitinib in patients with refractory or recurrent non-small cell lung cancerQ80249413
Pharmacokinetic study of the phase III, randomized, double-blind, multicenter trial (TRIBUTE) of paclitaxel and carboplatin combined with erlotinib or placebo in patients with advanced Non-small Cell Lung Cancer (NSCLC)Q82615461
Effects of smoking on the pharmacokinetics of erlotinibQ83143258
Selectivity for inhibition of nilotinib on the catalytic activity of human UDP-glucuronosyltransferasesQ86036741
Pharmacokinetic drug interactions of afatinib with rifampicin and ritonavirQ87050897
Clinical impact of gastric acid suppressing medication on the effectiveness of tyrosine kinase inhibitors in lung cancer patientsQ90022641
Applications of CYP450 testing in the clinical settingQ24621760
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer modelsQ24649935
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domainQ24794765
Tumor heterogeneity and resistance to EGFR-targeted therapy in advanced nonsmall cell lung cancer: challenges and perspectivesQ27014117
Promising Targets and Current Clinical Trials in Metastatic Non-Squamous NSCLCQ27025970
Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blockerQ27681964
Structure- and reactivity-based development of covalent inhibitors of the activating and gatekeeper mutant forms of the epidermal growth factor receptor (EGFR)Q27685359
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitorsQ27851633
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trialQ27851712
Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations.Q27852408
Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trialQ27852787
AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancerQ27853013
Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trialsQ27853120
AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancerQ27853158
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinomaQ27860881
Structure and Protein-Protein Interactions of Human UDP-GlucuronosyltransferasesQ28071266
Management of dose variability and side effects for individualized cancer pharmacotherapy with tyrosine kinase inhibitorsQ28087435
The ErbB/HER family of protein-tyrosine kinases and cancerQ28302611
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFRQ29547545
Erlotinib in previously treated non-small-cell lung cancerQ29547546
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trialQ29619975
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 studyQ29620648
Afatinib versus gefitinib in patients with EGFR mutation-positive advanced non-small-cell lung cancer: overall survival data from the phase IIb LUX-Lung 7 trialQ31160116
Comparison of the drug-drug interactions potential of erlotinib and gefitinib via inhibition of UDP-glucuronosyltransferasesQ33574627
New developments in the treatment of advanced squamous cell lung cancer: focus on afatinibQ33704088
Pharmacogenomics: translating functional genomics into rational therapeuticsQ33751829
Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitorsQ33769838
CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendantsQ34125166
Impact of drug transporter studies on drug discovery and developmentQ34215229
Toward precision medicine with next-generation EGFR inhibitors in non-small-cell lung cancer.Q34260686
Effects of Tobacco Smoking and Nicotine on Cancer TreatmentQ34303604
Approval summary for erlotinib for treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimenQ34451318
Pharmacokinetic drug interactions of gefitinib with rifampicin, itraconazole and metoprololQ34452644
Role of ATP-Binding Cassette and Solute Carrier Transporters in Erlotinib CNS Penetration and Intracellular AccumulationQ34472367
Update on epidermal growth factor receptor mutations in non-small cell lung cancerQ34594740
Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistanceQ40050525
Association of variant ABCG2 and the pharmacokinetics of epidermal growth factor receptor tyrosine kinase inhibitors in cancer patients.Q40168706
Gefitinib, an EGFR tyrosine kinase inhibitor, directly inhibits the function of P-glycoprotein in multidrug resistant cancer cells.Q40410062
Gefitinib (IRESSA) with vinorelbine or vinorelbine/cisplatin for chemotherapy-naive non-small cell lung cancer patients.Q40453635
Gefitinib enhances the antitumor activity and oral bioavailability of irinotecan in miceQ40502617
Relative contributions of the major human CYP450 to the metabolism of icotinib and its implication in prediction of drug-drug interaction between icotinib and CYP3A4 inhibitors/inducers using physiologically based pharmacokinetic modelingQ41104952
Drug-drug interactions in older patients with cancer: a report from the 15th Conference of the International Society of Geriatric Oncology, Prague, Czech Republic, November 2015.Q42019776
Gefitinib-phenytoin interaction is not correlated with the C-erythromycin breath test in healthy male volunteersQ42106492
Phase I study of icotinib hydrochloride (BPI-2009H), an oral EGFR tyrosine kinase inhibitor, in patients with advanced NSCLC and other solid tumorsQ42781680
Elevated international normalized ratio associated with concomitant warfarin and erlotinibQ42933546
Effect of gefitinib on warfarin antithrombotic activityQ43286571
Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignanciesQ43658492
United States Food and Drug Administration Drug Approval summary: Gefitinib (ZD1839; Iressa) tabletsQ44772598
Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1.Q44931908
Effect of gastric pH on erlotinib pharmacokinetics in healthy individuals: omeprazole and ranitidine.Q45977770
Gefitinib in combination with gemcitabine and vinorelbine in patients with metastatic breast cancer pre-treated with taxane and anthracycline chemotherapy: a phase I/II trial.Q46229939
Metabolic disposition of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in rat, dog and man.Q46375109
Cytochrome P450-dependent metabolism of gefitinibQ46402129
Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-type miceQ46413821
Drug interaction between complementary herbal medicines and gefitinibQ46452671
Rhabdomyolysis resulting from pharmacologic interaction between erlotinib and simvastatinQ46466772
Metabolism and excretion of erlotinib, a small molecule inhibitor of epidermal growth factor receptor tyrosine kinase, in healthy male volunteersQ46871053
Dacomitinib versus gefitinib as first-line treatment for patients with EGFR-mutation-positive non-small-cell lung cancer (ARCHER 1050): a randomised, open-label, phase 3 trialQ47257690
Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung CancerQ47450132
The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib.Q47642602
Clinical pharmacokinetics of tyrosine kinase inhibitorsQ34611569
Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspectsQ34713638
Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assayQ34762839
Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevanceQ35642041
Next-Generation Covalent Irreversible Kinase Inhibitors in NSCLC: Focus on AfatinibQ35807946
Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversityQ35922156
Efficacy and safety of icotinib in treating non-small cell lung cancer: a systematic evaluation and meta-analysis based on 15 studiesQ36205327
Drug-Drug Interaction Potentials of Tyrosine Kinase Inhibitors via Inhibition of UDP-GlucuronosyltransferasesQ36353657
Pharmacogenomics and individualized drug therapyQ36366823
Overcoming CYP1A1/1A2 mediated induction of metabolism by escalating erlotinib dose in current smokersQ37155636
The biological and clinical role of drug transporters at the intestinal barrierQ37318372
Tyrosine kinase inhibitor enhances the bioavailability of oral irinotecan in pediatric patients with refractory solid tumorsQ37369825
Clinical Pharmacokinetics and Pharmacodynamics of AfatinibQ37650711
EGFR kinase inhibitors and gastric acid suppressants in EGFR-mutant NSCLC: a retrospective database analysis of potential drug interaction.Q37709182
Cytochrome P450 variations in different ethnic populationsQ37979866
Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH-dependent solubility the Achilles heel of targeted therapy?Q38022125
Hepatotoxicity of Tyrosine Kinase Inhibitors: Clinical and Regulatory PerspectivesQ38101884
Current status of targeted therapy for anaplastic lymphoma kinase-rearranged non-small cell lung cancerQ38148969
Epidermal growth factor receptor tyrosine-kinase inhibitor treatment resistance in non-small cell lung cancer: biological basis and therapeutic strategiesQ38168795
Afatinib: a review of its use in the treatment of advanced non-small cell lung cancerQ38179266
Drug-drug interactions with tyrosine-kinase inhibitors: a clinical perspectiveQ38225680
Oral epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small cell lung cancer: comparative pharmacokinetics and drug-drug interactionsQ38229948
Gastric Acid suppression is associated with decreased erlotinib efficacy in non-small-cell lung cancerQ38253338
Common EGFR-mutated subgroups (Del19/L858R) in advanced non-small-cell lung cancer: chasing better outcomes with tyrosine kinase inhibitorsQ38335360
Icotinib, a selective EGF receptor tyrosine kinase inhibitor, for the treatment of non-small-cell lung cancerQ38352862
Targeted therapy for non-small cell lung cancer: current standards and the promise of the futureQ38390200
First-line erlotinib versus gemcitabine/cisplatin in patients with advanced EGFR mutation-positive non-small-cell lung cancer: analyses from the phase III, randomized, open-label, ENSURE studyQ38536391
Next-generation epidermal growth factor receptor tyrosine kinase inhibitors in epidermal growth factor receptor -mutant non-small cell lung cancerQ38742732
Afatinib versus gefitinib as first-line treatment of patients with EGFR mutation-positive non-small-cell lung cancer (LUX-Lung 7): a phase 2B, open-label, randomised controlled trialQ38809376
Tyrosine Kinase Inhibitors and Proton Pump Inhibitors: An Evaluation of Treatment OptionsQ39013343
Inhibition of human UDP-glucuronosyltransferase enzymes by lapatinib, pazopanib, regorafenib and sorafenib: Implications for hyperbilirubinemiaQ39033152
Population pharmacokinetics and exposure-response of osimertinib in patients with non-small cell lung cancerQ39069017
Next-Generation EGFR Tyrosine Kinase Inhibitors for Treating EGFR-Mutant Lung Cancer beyond First LineQ39114552
Dacomitinib for the treatment of advanced or metastatic non-small-cell lung cancer.Q39198033
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectdrug interactionQ718753
P304page(s)5467-5484
P577publication date2019-07-09
P13046publication type of scholarly workreview articleQ7318358
P1433published inOncoTargets and TherapyQ7092081
P1476titleComparative review of drug-drug interactions with epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small-cell lung cancer
P478volume12

Reverse relations

Q90398831Concurrent proton-pump inhibitors increase risk of death for lung cancer patients receiving 1st-line gefitinib treatment - a nationwide population-based studycites workP2860

Search more.