Impact of clinical features on the efficacy of osimertinib therapy in patients with T790M-positive non-small cell lung cancer and acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors

scientific article published on 01 June 2019

Impact of clinical features on the efficacy of osimertinib therapy in patients with T790M-positive non-small cell lung cancer and acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.21037/JTD.2019.06.03
P932PMC publication ID6626778
P698PubMed publication ID31372272

P50authorYusuke OkumaQ41393127
P2093author name stringKaoru Kubota
Yasuhiro Kato
Akihiko Gemma
Masahiro Seike
Yukio Hosomi
Tatsuru Okamura
Kageaki Watanabe
Makiko Yomota
Shoko Kawai
P2860cites workErlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trialQ27851712
Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trialQ27852787
AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancerQ27853158
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)Q28131668
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFRQ29547545
Osimertinib for pretreated EGFR Thr790Met-positive advanced non-small-cell lung cancer (AURA2): a multicentre, open-label, single-arm, phase 2 studyQ33436083
Lung adenocarcinoma patients of young age have lower EGFR mutation rate and poorer efficacy of EGFR tyrosine kinase inhibitors.Q33897441
Impact of Smoking and Brain Metastasis on Outcomes of Advanced EGFR Mutation Lung Adenocarcinoma Patients Treated with First Line Epidermal Growth Factor Receptor Tyrosine Kinase InhibitorsQ35587238
Real-World Data on Prognostic Factors for Overall Survival in EGFR Mutation-Positive Advanced Non-Small Cell Lung Cancer Patients Treated with First-Line GefitinibQ36372611
Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway.Q37379113
Are EGFR tyrosine kinase inhibitors effective in elderly patients with EGFR-mutated non-small cell lung cancer?Q38845975
An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor.Q40384809
Association Between Plasma Genotyping and Outcomes of Treatment With Osimertinib (AZD9291) in Advanced Non-Small-Cell Lung CancerQ41646881
The resistance mechanisms and treatment strategies for EGFR-mutant advanced non-small-cell lung cancerQ42378535
A prospective, phase II, open-label study (JO22903) of first-line erlotinib in Japanese patients with epidermal growth factor receptor (EGFR) mutation-positive advanced non-small-cell lung cancer (NSCLC).Q42611912
First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapyQ46118410
Dacomitinib versus gefitinib as first-line treatment for patients with EGFR-mutation-positive non-small-cell lung cancer (ARCHER 1050): a randomised, open-label, phase 3 trialQ47257690
Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung CancerQ47450132
Osimertinib or Platinum-Pemetrexed in EGFR T790M-Positive Lung Cancer.Q48020812
High ratio of T790M to EGFR activating mutations correlate with the osimertinib response in non-small-cell lung cancer.Q51745636
Predictive factors for interstitial lung disease, antitumor response, and survival in non-small-cell lung cancer patients treated with gefitinib.Q51802507
Real world treatment and outcomes in EGFR mutation-positive non-small cell lung cancer: Long-term follow-up of a large patient cohort.Q52678697
Impact of TP53 Mutations on Outcome in EGFR-Mutated Patients Treated with First-Line Tyrosine Kinase Inhibitors.Q52839850
Osimertinib in Japanese patients with EGFR T790M mutation-positive advanced non-small cell lung cancer: AURA3 trial.Q54114179
Impact of cigarette smoking on response to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors in lung adenocarcinoma with activating EGFR mutations.Q54368639
Differential microRNA expression profiles between young and old lung adenocarcinoma patients.Q55243832
Osimertinib compared docetaxel-bevacizumab as third-line treatment in EGFR T790M mutated non-small-cell lung cancerQ88954090
P433issue6
P304page(s)2350-2360
P577publication date2019-06-01
P1433published inJournal of thoracic diseaseQ26841814
P1476titleImpact of clinical features on the efficacy of osimertinib therapy in patients with T790M-positive non-small cell lung cancer and acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors
P478volume11

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cites work (P2860)
Q92424714Impact of clinical features of epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) patients on osimertinib efficacy
Q91792623The impact of age and performance status on the efficacy of osimertinib in patients with EGFR T790M-positive non-small cell lung cancer

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