Pamiparib in combination with tislelizumab in patients with advanced solid tumours: results from the dose-escalation stage of a multicentre, open-label, phase 1a/b trial

scientific article published on 01 August 2019

Pamiparib in combination with tislelizumab in patients with advanced solid tumours: results from the dose-escalation stage of a multicentre, open-label, phase 1a/b trial is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1470-2045(19)30396-1
P698PubMed publication ID31378459

P50authorPaul HarnettQ42873365
Tarek M MeniawyQ58414869
P2093author name stringMichael Friedlander
Bo Gao
Michael Millward
Song Mu
John Wu
Ben Markman
Linda Mileshkin
Virginia Paton
Christie Norris
Joanne Lundy
Alison Freimund
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Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancerQ29615679
Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working GroupQ33566395
The DNA damage response, immunity and cancerQ36567952
Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancerQ37046405
NKG2D ligands in tumor immunityQ37287179
Incidence and risk of hepatic toxicities with PD-1 inhibitors in cancer patients: a meta-analysisQ37306007
Definitions for response and progression in ovarian cancer clinical trials incorporating RECIST 1.1 and CA 125 agreed by the Gynecological Cancer Intergroup (GCIG).Q37832624
The PARP1 inhibitor BMN 673 exhibits immunoregulatory effects in a Brca1(-/-) murine model of ovarian cancerQ38866964
Mutational Landscape and Sensitivity to Immune Checkpoint BlockersQ38889870
Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trialQ46270437
Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upQ50205173
DNA Repair Deficiency and Immunotherapy Response.Q54668423
PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression.Q55004657
The binding of an anti-PD-1 antibody to FcγRΙ has a profound impact on its biological functions.Q55417775
Immune-related adverse events are linked with improved progression-free survival in patients receiving anti-PD-1/PD-L1 therapyQ57811628
P433issue9
P921main subjectmulticenter clinical trialQ6934595
P304page(s)1306-1315
P577publication date2019-08-01
P1433published inLancet Oncology CommissionQ13747613
P1476titlePamiparib in combination with tislelizumab in patients with advanced solid tumours: results from the dose-escalation stage of a multicentre, open-label, phase 1a/b trial
P478volume20

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cites work (P2860)
Q92395353Combining PARP inhibition with PD-1 inhibitors
Q96303222PD-1/PD-L1 Based Combinational Cancer Therapy: Icing on the Cake
Q98945207Poly(ADP-ribose) polymerase inhibition: past, present and future
Q98164379Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence
Q95841163Therapeutic Potential of Combining PARP Inhibitor and Immunotherapy in Solid Tumors
Q90417275Tislelizumab: First Approval

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