Sphingosine-1-Phosphate and Macrophage Biology-How the Sphinx Tames the Big Eater

scientific article published on 19 July 2019

Sphingosine-1-Phosphate and Macrophage Biology-How the Sphinx Tames the Big Eater is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3389/FIMMU.2019.01706
P932PMC publication ID6658986
P698PubMed publication ID31379883

P50authorAndreas WeigertQ48297787
P2093author name stringBernhard Brüne
Catherine Olesch
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Human and rat alveolar macrophages express multiple EDG receptorsQ30665132
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Sphingosine kinase-1 (SphK-1) regulates Mycobacterium smegmatis infection in macrophagesQ33586246
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.Q33773569
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Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.Q33796082
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Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritisQ34140190
Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesisQ47447095
Apoptotic cells enhance sphingosine-1-phosphate receptor 1 dependent macrophage migrationQ47806925
S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells.Q48259591
S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β.Q48355741
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitorsQ48425484
Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages.Q48509512
The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages.Q49393104
Pro-phagocytic Effects of Thymoquinone on Cigarette Smoke-exposed Macrophages Occur by Modulation of the Sphingosine-1-phosphate Signalling SystemQ50856270
High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expressionQ50981100
Macrophages Facilitate Electrical Conduction in the Heart.Q51041551
Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosisQ51055815
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Sphingosine-1-phosphate Receptor 2 Signaling Promotes Caspase-11-dependent Macrophage Pyroptosis and Worsens Escherichia coli Sepsis Outcome.Q52605011
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Sphingolipids Are Dual Specific Drug Targets for the Management of Pulmonary Infections: PerspectiveQ37834436
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Apoptotic cell-derived factors induce arginase II expression in murine macrophages by activating ERK5/CREB.Q38340109
Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell ActivationQ38605015
S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1β or Lipocalin-2.Q38626918
Sphingosine 1-Phosphate and Atherosclerosis.Q38654911
Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talkQ38712433
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Erythropoeitin Signaling in Macrophages Promotes Dying Cell Clearance and Immune Tolerance.Q38794549
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Macrophage NOS2 in Tumor LeukocytesQ38843508
Recent advances in the development of sphingosine kinase inhibitorsQ38864118
Sphingolipids in viral infectionQ38926960
Activation of ATP secretion via volume-regulated anion channels by sphingosine-1-phosphate in RAW macrophagesQ38981282
Transcriptional control of monocyte and macrophage developmentQ39221646
Does niche competition determine the origin of tissue-resident macrophages?Q39276574
Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapyQ39280710
Characterization of secreted sphingosine-1-phosphate lyases required for virulence and intracellular survival of Burkholderia pseudomalleiQ39385841
The immune contexture in cancer prognosis and treatmentQ39456999
Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2.Q39568139
Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia.Q39758728
Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident MacrophagesQ39907854
Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signalQ36804936
Trophic macrophages in development and diseaseQ36829147
Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathwayQ36854286
Chop Deficiency Protects Mice Against Bleomycin-induced Pulmonary Fibrosis by Attenuating M2 Macrophage ProductionQ36939776
Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavitiesQ37010333
The alliance of sphingosine-1-phosphate and its receptors in immunityQ37010807
Redox control of inflammation in macrophagesQ37032282
The vascular S1P gradient-cellular sources and biological significanceQ37085319
Sphingosine kinases are not required for inflammatory responses in macrophagesQ37289270
Specification of tissue-resident macrophages during organogenesis.Q37343167
Involvement of sphingosine 1-phosphate (SIP)/S1P3 signaling in cholestasis-induced liver fibrosisQ37362062
Deoxycholic Acid Triggers NLRP3 Inflammasome Activation and Aggravates DSS-Induced Colitis in Mice.Q37443636
When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy.Q37454105
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Regulation of macrophage function by sphingosine-1-phosphate.Q37558824
K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.Q37686404
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Selective attenuation of Toll-like receptor 2 signalling may explain the atheroprotective effect of sphingosine 1-phosphate.Q39992138
Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophagesQ40029162
Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720.Q40080527
A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil RecruitmentQ40081249
Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate.Q40102693
Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF-beta1.Q40104489
S1P2/G12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population.Q40279381
Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate.Q40280838
Sphingosine 1-phosphate Receptor 2 Signaling Suppresses Macrophage Phagocytosis and Impairs Host Defense against SepsisQ41096093
Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosisQ41570690
Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP.Q41782419
Heme oxygenase-1 contributes to an alternative macrophage activation profile induced by apoptotic cell supernatants.Q42142782
Interferon-γ Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF.Q42513727
The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewalQ42744709
The Origin and Maturity of Dendritic Cells Determine the Pattern of Sphingosine 1-Phosphate Receptors Expressed and Required for Efficient MigrationQ42913146
Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditureQ43062138
Editorial: The Cell Types of FibrosisQ43075060
Sphingolipidomics: a valuable tool for understanding the roles of sphingolipids in biology and diseaseQ43138779
S1P(2), the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice.Q43196159
The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemiaQ43283062
Sphingosine-1-phosphate receptor 3 promotes recruitment of monocyte/macrophages in inflammation and atherosclerosisQ43432914
FTY720 attenuates tubulointerstitial inflammation and fibrosis in subtotally nephrectomized ratsQ44062977
Sphingosine-1-phosphate signalling induces the production of Lcn-2 by macrophages to promote kidney regenerationQ44125780
Macrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repairQ44163378
Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophagesQ44371529
Liver involvement in sphingosine 1-phosphate dynamism revealed by adenoviral hepatic overexpression of apolipoprotein M.Q44524146
Normal neutrophil functions in sphingosine kinase type 1 and 2 knockout miceQ44777835
The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesisQ44892426
Sphingosine 1-phosphate induces antimicrobial activity both in vitro and in vivoQ44896089
Expression of the lysophospholipid receptor family and investigation of lysophospholipid-mediated responses in human macrophagesQ44907208
Sphingosine kinase 1 (SK1) is recruited to nascent phagosomes in human macrophages: inhibition of SK1 translocation by Mycobacterium tuberculosisQ45304872
KRP-203, sphingosine 1-phosphate receptor type 1 agonist, ameliorates atherosclerosis in LDL-R-/- miceQ45405428
The role of TRKA signaling in IL-10 production by apoptotic tumor cell-activated macrophagesQ45720263
The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1alpha in macrophages via sphingosine-1-phosphate and transforming growth factor-beta.Q45956195
Lipids regulate P2X7-receptor-dependent actin assembly by phagosomes via ADP translocation and ATP synthesis in the phagosome lumenQ46143631
Sphingosine-1-phosphate receptors stimulate macrophage plasma-membrane actin assembly via ADP release, ATP synthesis and P2X7R activationQ46143632
S1PR3 Signaling Drives Bacterial Killing and Is Required for Survival in Bacterial Sepsis.Q46315054
Tissue-Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic CellsQ46342472
Defects of High-Density Lipoproteins in Coronary Artery Disease Caused by Low Sphingosine-1-Phosphate Content: Correction by Sphingosine-1-Phosphate-LoadingQ46377068
Delivery of monocyte lineage cells in a biomimetic scaffold enhances tissue repairQ46489164
Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differencesQ46516651
Sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis is involved in liver fibrosis-associated angiogenesisQ46622055
Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expressionQ46820182
A phase 2 study of the sphingosine-1-phosphate antibody sonepcizumab in patients with metastatic renal cell carcinomaQ46979728
TAMeless traitors: macrophages in cancer progression and metastasisQ47096116
Microglia and Monocytes/Macrophages Polarization Reveal Novel Therapeutic Mechanism against Stroke.Q47106944
Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD.Q47112426
Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2.Q47214403
Sinusoidal protection by sphingosine-1-phosphate receptor 1 agonist in liver ischemia-reperfusion injuryQ47259871
Extracellular and Intracellular Actions of Sphingosine-1-PhosphateQ34183703
Human dermal CD14⁺ cells are a transient population of monocyte-derived macrophagesQ34244161
Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activityQ34328383
Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyondQ34364844
Macrophages in atherosclerosis: a dynamic balance.Q34368005
Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivoQ34420830
Environment drives selection and function of enhancers controlling tissue-specific macrophage identitiesQ34452301
Macrophages in Tissue Repair, Regeneration, and FibrosisQ34518415
Immune surveillance of tumorsQ34579196
Abandoning M1/M2 for a Network Model of Macrophage FunctionQ34677978
Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?Q34691487
Lysophospholipid regulation of mononuclear phagocytesQ34691518
Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation.Q34748080
Immunology's foundation: the 100-year anniversary of the Nobel Prize to Paul Ehrlich and Elie MetchnikoffQ34787221
A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumorsQ34809705
The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursorsQ34901297
Sphingolipids in pulmonary fibrosisQ34921823
Posttranslational modification of Sirt6 activity by peroxynitriteQ35118010
Role of sphingosine-1-phosphate (S1P) and S1P receptor 2 in the phagocytosis of Cryptococcus neoformans by alveolar macrophagesQ35118828
High density lipoprotein stimulated migration of macrophages depends on the scavenger receptor class B, type I, PDZK1 and Akt1 and is blocked by sphingosine 1 phosphate receptor antagonistsQ35238369
Myocardial infarction: a critical role of macrophages in cardiac remodelingQ35291097
Metchnikoff's policemen: macrophages in development, homeostasis and regenerationQ35577477
Sphingosine-1-phosphate signaling and its role in diseaseQ35661485
Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD).Q35814901
Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1.Q35898425
C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophagesQ35985763
Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in MiceQ36012100
The sphingosine-1-phosphate analogue FTY720 impairs mucosal immunity and clearance of the enteric pathogen Citrobacter rodentium.Q36211058
Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning.Q36561924
Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagyQ36607525
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.Q36627430
Essential role for SphK1/S1P signaling to regulate hypoxia-inducible factor 2α expression and activity in cancerQ36748690
The apolipoprotein m-sphingosine-1-phosphate axis: biological relevance in lipoprotein metabolism, lipid disorders and atherosclerosisQ36790267
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectmacrophageQ184204
P304page(s)1706
P577publication date2019-07-19
P1433published inFrontiers in ImmunologyQ27723748
P1476titleSphingosine-1-Phosphate and Macrophage Biology-How the Sphinx Tames the Big Eater
P478volume10

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cites work (P2860)
Q89552038Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks
Q90074713Unbalanced Sphingolipid Metabolism and Its Implications for the Pathogenesis of Psoriasis

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