Serotonin and motherhood: From molecules to mood

scientific article published on 13 March 2019

Serotonin and motherhood: From molecules to mood is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YFRNE.2019.03.001
P932PMC publication ID6541513
P698PubMed publication ID30878665

P2093author name stringMing Li
Joseph S Lonstein
Jodi L Pawluski
P2860cites workElevated stress hormone levels and antidepressant treatment starting before pregnancy affect maternal care and litter characteristics in an animal model of depression.Q52598648
Behavioral mechanisms underlying the maternal disruptive effect of serotonin 5-HT2A receptor activation in Sprague-Dawley rats.Q52608270
Serotonin-specific lesions of the dorsal raphe disrupt maternal aggression and caregiving in postpartum rats.Q52691177
Behavior-state matching and synchrony in mother-infant interactions of nondepressed versus depressed dyadsQ56637144
Pharmacologic Treatment of Perinatal DepressionQ57165675
Variations in maternal 5-HTTLPR affect observed sensitive parentingQ57337534
Monoamine neurotransmitters and metabolites during the estrous cycle, pregnancy, and the postpartum periodQ68006630
The 5-HT 1A receptor agonist, 8-OH-DPAT, preferentially activates cell body 5-HT autoreceptors in rat brain in vivoQ69062043
The role of 5HT1A receptors in the modulation of the acoustic startle reflex in ratsQ69303732
Localization of oxytocin receptor messenger ribonucleic acid in the rat brainQ70473305
Effects of intracerebroventricular administration of 5-HT receptor agonists on the maternal aggression of ratsQ72113815
Oxytocin activates the postpartum onset of rat maternal behavior in the ventral tegmental and medial preoptic areasQ72637855
Enhancement by the putative 5-HT receptor agonist 8-OH-2-(di-n-propylamino)tetralin of the acoustic startle response in the ratQ72783248
Increasing use of antidepressants in pregnancyQ80426520
Serotonin transporter allelic variation in mothers predicts maternal sensitivity, behavior and attitudes toward 6-month-old infantsQ83199439
Neuronal Cell DeathQ87906376
Perinatal SSRI medications and offspring hippocampal plasticity: interaction with maternal stress and sexQ88956537
Role of Estradiol in the Expression of Genes Involved in Serotonin Neurotransmission: Implications for Female DepressionQ89341106
Selective serotonin reuptake inhibitor effects on neural biomarkers of perinatal depressionQ90123319
The dynamic serotonin system of the maternal brainQ90387675
Maternal experience and adult neurogenesis in mammals: Implications for maternal care, cognition, and mental healthQ91194175
GABAergic modulation of serotonergic neurons in the dorsal raphe nucleusQ91260997
Parenting and plasticityQ24616989
Growth retardation and altered autonomic control in mice lacking brain serotoninQ24658409
Using animal models to study post-partum psychiatric disordersQ26825947
Hippocampal plasticity during the peripartum period: influence of sex steroids, stress and ageingQ26862576
Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorderQ27015917
Behavioral and pharmacological investigation of anxiety and maternal responsiveness of postpartum female rats in a pup elevated plus mazeQ27330595
Brain serotonin determines maternal behavior and offspring survivalQ27349765
Neuronal regulation: A mechanism for synaptic pruning during brain maturationQ28138934
A review of central 5-HT receptors and their functionQ28142963
EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONSQ28201187
Molecular, pharmacological and functional diversity of 5-HT receptorsQ28206145
A unique central tryptophan hydroxylase isoformQ28210504
Impaired maternal behavior in mice lacking norepinephrine and epinephrineQ28507556
Use of SSRI and SNRI Antidepressants during Pregnancy: A Population-Based Study from Denmark, Iceland, Norway and SwedenQ28551620
Cellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of adult ratQ28565096
Gestational stress leads to depressive-like behavioural and immunological changes in the ratQ28581519
The ETS domain factor Pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genesQ28645883
Adult neurogenesis in the mammalian central nervous systemQ29618706
Common and divergent psychobiological mechanisms underlying maternal behaviors in non-human and human mammalsQ30380217
Age, sex, and reproductive hormone effects on brain serotonin-1A and serotonin-2A receptor binding in a healthy populationQ30423753
5-HT1A sex based differences in Bmax, in vivo KD, and BPND in the nonhuman primateQ30432949
Noradrenergic alpha-2 receptor modulators in the ventral bed nucleus of the stria terminalis: effects on anxiety behavior in postpartum and virgin female ratsQ30433556
Interactions between corticotropin-releasing factor and the serotonin 1A receptor system on acoustic startle amplitude and prepulse inhibition of the startle response in two rat strainsQ30459612
Maternal defense is modulated by beta adrenergic receptors in lateral septum in miceQ30466932
Serotonergic transcriptional programming determines maternal behavior and offspring survivalQ30487523
Inactivation or inhibition of neuronal activity in the medial prefrontal cortex largely reduces pup retrieval and grouping in maternal ratsQ30493951
Medication use in pregnancy: a cross-sectional, multinational web-based studyQ30572132
Monoamine neurocircuitry in depression and strategies for new treatmentsQ30619239
Neonatal outcomes after prenatal exposure to selective serotonin reuptake inhibitor antidepressants and maternal depression using population-based linked health dataQ31052150
Rapid visual learning in the rat: effects at the 5-HT1a receptor subtype.Q52164960
Hippocampal volume reduction in major depression.Q52172075
A behavioral mechanistic investigation of the role of 5-HT1A receptors in the mediation of rat maternal behavior.Q52591688
Importance of beta-noradrenergic receptors in the olfactory bulb of sheep for recognition of lambsQ38340659
How to make a midbrain dopaminergic neuronQ38503992
Neuroplasticity in the maternal hippocampus: Relation to cognition and effects of repeated stressQ38539991
Affective changes during the postpartum period: Influences of genetic and experiential factors.Q38554038
Serotonin and brain function: a tale of two receptorsQ38600048
The Neurobiology of Postpartum Anxiety and DepressionQ38764938
Structural and Functional Plasticity in the Maternal Brain CircuitryQ38944916
The neurobiology of parenting: A neural circuit perspectiveQ39030336
Ventral tegmental area: cellular heterogeneity, connectivity and behaviourQ39067598
Perinatal selective serotonin reuptake inhibitor medication (SSRI) effects on social behaviors, neurodevelopment and the epigenomeQ39284125
Parity modifies the effects of fluoxetine and corticosterone on behavior, stress reactivity, and hippocampal neurogenesis.Q39286694
A survey of neuroimmune changes in pregnant and postpartum female ratsQ39337538
The impact of prenatal serotonin reuptake inhibitor (SRI) antidepressant exposure and maternal mood on mother-infant interactions at 3 months of age.Q39409209
Pregnancy decreases oestrogen receptor alpha expression and pyknosis, but not cell proliferation or survival, in the hippocampus.Q39902963
Serotonin 2A receptor agonist binding in the human brain with [(11)C]Cimbi-36: Test-retest reproducibility and head-to-head comparison with the antagonist [(18)F]altanserinQ39997514
Effects of chronic typical and atypical antipsychotic drug treatment on maternal behavior in ratsQ40423850
Effects of typical and atypical antipsychotic drugs on maternal behavior in postpartum female ratsQ40497463
Confounding by Indication in Clinical ResearchQ40499641
The spectrum of behaviors influenced by serotoninQ40847700
Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS.Q40901462
Serotonin receptors and animal models of aggressive behaviorQ40978226
Role of 5-HT in stress, anxiety, and depression.Q41052750
8-Hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicits eating in free-feeding rats by acting on central serotonin neuronsQ41353222
Prolactin action in the medial preoptic area is necessary for postpartum maternal nursing behaviorQ42263648
Gender and gonadal status modulation of dorsal raphe nucleus serotonergic neurons. Part I: effects of gender and pregnancyQ42435195
Specific neurotoxin lesions of median raphe serotonergic neurons disrupt maternal behavior in the lactating rat.Q42461080
Distribution and cellular localization of the serotonin type 2C receptor messenger RNA in human brainQ42474817
The distribution of 5-HT1A and 5-HT2A receptor mRNA in human brain.Q42487064
Behavioral, pharmacological and neuroanatomical analysis of serotonin 2C receptor agonism on maternal behavior in ratsQ42647430
Serotonin 1A, 1B, and 7 receptors of the rat medial nucleus accumbens differentially regulate feeding, water intake, and locomotor activityQ42846618
Prolactin-induced mitogenesis in the subventricular zone of the maternal brain during early pregnancy is essential for normal postpartum behavioral responses in the motherQ43059522
Pyramidal neurons in rat prefrontal cortex projecting to ventral tegmental area and dorsal raphe nucleus express 5-HT2A receptorsQ43115257
Editorial: Neuromodulation of executive circuitsQ43230370
Control of dorsal raphe serotonergic neurons by the medial prefrontal cortex: Involvement of serotonin-1A, GABA(A), and glutamate receptors.Q43820009
Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activationQ44100268
Adult Neurogenesis in Sheep: Characterization and Contribution to Reproduction and BehaviorQ44110504
GABA(A) receptor regulation of kyphotic nursing and female sexual behavior in the caudal ventrolateral periaqueductal gray of postpartum ratsQ44130888
Intracellular preoptic and striatal monoamines in pregnant and lactating rats: possible role in maternal behaviorQ44410523
Antagonizing 5-HT₂A receptors with M100907 and stimulating 5-HT₂C receptors with Ro60-0175 blocks cocaine-induced locomotion and zif268 mRNA expression in Sprague-Dawley rats.Q44443195
Gestational stress induces post-partum depression-like behaviour and alters maternal care in ratsQ44646643
Abnormal maternal behavior, altered sociability, and impaired serotonin metabolism in Rai1-transgenic miceQ44946203
Expression of serotonin 5-HT2C receptors in GABAergic cells of the anterior raphe nucleiQ45225824
Chronic fluoxetine treatment and maternal adversity differentially alter neurobehavioral outcomes in the rat dam.Q45343702
Temporary inactivation of ventral tegmental area neurons with either muscimol or baclofen reversibly disrupts maternal behavior in rats through different underlying mechanisms.Q45918880
Increased blood serotonin concentrations are correlated with reduced tension/anxiety in healthy postpartum lactating womenQ46180728
Mood changes after delivery: role of the serotonin transporter geneQ46269029
Sex Differences in the Regulation of Offensive Aggression and Dominance by Arginine-VasopressinQ46335352
Ovarian steroids and serotonin neural functionQ33538362
Effects of 5-hydroxytryptamine 2C receptor agonist MK212 and 2A receptor antagonist MDL100907 on maternal behavior in postpartum female ratsQ33667703
Vulnerability genes or plasticity genes?Q33710285
Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expressionQ33719414
c-Fos identification of neuroanatomical sites associated with haloperidol and clozapine disruption of maternal behavior in the rat.Q33725056
Sedation and disruption of maternal motivation underlie the disruptive effects of antipsychotic treatment on rat maternal behaviorQ33780555
Oxytocin-dopamine interactions mediate variations in maternal behavior in the rat.Q33848243
A serotonin transporter gene polymorphism predicts peripartum depressive symptoms in an at-risk psychiatric cohortQ33940182
The tryptophan utilization concept in pregnancyQ34011753
Effects of steroid hormones on neurogenesis in the hippocampus of the adult female rodent during the estrous cycle, pregnancy, lactation and aging.Q34017019
Divergent plasticity of prefrontal cortex networksQ34021648
GABAA receptor signaling in caudal periaqueductal gray regulates maternal aggression and maternal care in miceQ34053942
Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactinQ34168429
Pre-gestational stress reduces the ratio of 5-HIAA to 5-HT and the expression of 5-HT1A receptor and serotonin transporter in the brain of foetal rat.Q34175768
Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminalsQ34276042
Focus on The 5-HT1A receptor: emerging role of a gene regulatory variant in psychopathology and pharmacogenetics.Q34389739
Gestation-induced cell proliferation in the rat brainQ34414946
Diverse actions of ovarian steroids in the serotonin neural systemQ34572423
Maternal experience inhibits the production of immature neurons in the hippocampus during the postpartum period through elevations in adrenal steroidsQ34614044
Early motherhood in rats is associated with a modification of hippocampal functionQ34653732
Serotonin 1A receptors and sexual behavior in female rats: a review.Q34657853
Reproductive experience alters hippocampal neurogenesis during the postpartum period in the dam.Q34687569
Serotonin: a reviewQ34777881
Molecular biology of 5-HT receptorsQ34788155
Mother-infant interactions in free-ranging rhesus macaques: relationships between physiological and behavioral variables.Q34923791
Role of mother's genes and environment in postpartum depressionQ35002581
The effects of dopaminergic/serotonergic reuptake inhibition on maternal behavior, maternal aggression, and oxytocin in the rat.Q35031118
Combined norepinephrine/serotonergic reuptake inhibition: effects on maternal behavior, aggression, and oxytocin in the rat.Q35042610
Enhanced responsiveness to selective serotonin reuptake inhibitors during lactationQ35092485
Chronic gestational stress leads to depressive-like behavior and compromises medial prefrontal cortex structure and function during the postpartum periodQ35110745
Neuroendocrine regulation of maternal behaviorQ35125962
Platelet serotonin levels support depression scores for women with postpartum depressionQ35574537
Serotonin and neurogenesis in the hippocampal dentate gyrus of adult mammals.Q35887030
Stress-induced alterations in 5-HT1A receptor transcriptional modulators NUDR and Freud-1Q35887982
Raphe serotonin neuron-specific oxytocin receptor knockout reduces aggression without affecting anxiety-like behavior in male mice onlyQ35954848
The serotonin-1A receptor distribution in healthy men and women measured by PET and [carbonyl-11C]WAY-100635.Q46548932
Selective serotonin reuptake inhibitor prescribing before, during and after pregnancy: a population-based study in six European regions.Q46625070
Ventral tegmental area involvement in pair bonding in male prairie volesQ46705455
GABA receptor agonists in the medial preoptic area and maternal behavior in lactating ratsQ46811927
Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET.Q46883479
Stress during gestation alters postpartum maternal care and the development of the offspring in a rodent model.Q46927080
Activation of 5-HT2A receptor disrupts rat maternal behaviorQ47317394
Previous and recent maternal experiences modulate pups' incentive value relative to a male without affecting maternal behavior in postpartum estrous rats.Q47384109
Rodent models of depression: forced swimming and tail suspension behavioral despair tests in rats and miceQ47566871
Perinatal fluoxetine increases hippocampal neurogenesis and reverses the lasting effects of pre-gestational stress on serum corticosterone, but not on maternal behavior, in the rat dam.Q47567736
Extensive juvenile "babysitting" facilitates later adult maternal responsiveness, decreases anxiety, and increases dorsal raphe tryptophan hydroxylase-2 expression in female laboratory ratsQ47591966
Postpartum Lactation-Mediated Behavioral Outcomes and Drug Responses in a Spontaneous Mouse Model of Obsessive-Compulsive DisorderQ47614008
Perinatal fluoxetine effects on social play, the HPA system, and hippocampal plasticity in pre-adolescent male and female rats: Interactions with pre-gestational maternal stressQ47689716
Oxytocin and Parental BehaviorsQ47739804
Voluntary running influences the efficacy of fluoxetine in a model of postpartum depression.Q47753891
Rat dams exposed repeatedly to a daily brief separation from the pups exhibit increased maternal behavior, decreased anxiety and altered levels of receptors for estrogens (ERα, ERβ), oxytocin and serotonin (5-HT1A) in their brainQ47775262
Effects of venlafaxine and chronic unpredictable stress on behavior and hippocampal neurogenesis of rat damsQ47778468
Control of the serotonergic system by the medial prefrontal cortex: Potential role in the etiology of PTSD and depressive disordersQ47903925
Disentangling Maternal Depression and Antidepressant Use During Pregnancy as Risks for Autism in ChildrenQ47913634
Motherhood and infant contact regulate neuroplasticity in the serotonergic midbrain dorsal rapheQ47931720
Gestational stress and fluoxetine treatment differentially affect plasticity, methylation and serotonin levels in the PFC and hippocampus of rat damsQ48058699
Effects of maternal stress and perinatal fluoxetine exposure on behavioral outcomes of adult male offspring.Q48064108
Tryptophan pathway alterations in the postpartum period and in acute postpartum psychosis and depressionQ48072832
Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in ratsQ48131051
Maternal behavior of female rats with 6-OHDA lesions in the ventral striatum: characterization of the pup retrieval deficitQ48142578
Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptorsQ48149092
Importance of noradrenergic mechanisms in the olfactory bulbs for the maternal behaviour of miceQ48149556
Ovarian steroid effects on serotonin 1A, 2A and 2C receptor mRNA in macaque hypothalamusQ48312511
Parental behaviors in rats and miceQ48347921
Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptorsQ48436884
Effect of local injection of 8-OH-DPAT into the dorsal or median raphe nuclei on extracellular levels of serotonin in serotonergic projection areas in the rat brainQ48507790
Oxytocin receptors in the nucleus accumbens facilitate "spontaneous" maternal behavior in adult female prairie volesQ48521775
8-OH-DPAT in the median raphe, dorsal periaqueductal gray and corticomedial amygdala nucleus decreases, but in the medial septal area it can increase maternal aggressive behavior in ratsQ48550270
Comparative anatomical distribution of 5-HT1A receptor mRNA and 5-HT1A binding in rat brain — a combined in situ hybridisation/in vitro receptor autoradiographic studyQ48640469
Dorsal raphe-hypothalamic projections provide the stimulatory serotonergic input to suckling-induced prolactin releaseQ48716308
Brain Serotonin Content: Physiological Regulation by Plasma Neutral Amino AcidsQ48719501
Serotonin and dopamine systems regulating alcohol intakeQ48818703
Rat brain monoamine and Serotonin S2 receptor changes during pregnancyQ48892362
Stress and the pregnant female: Impact on hippocampal cell proliferation, but not affective-like behaviors.Q48897179
Postpartum luteinizing hormone release and maternal behavior in the rat after late-gestational depletion of hypothalamic norepinephrineQ48959048
Perinatal Selective Serotonin Reuptake Inhibitor (SSRI) Effects on Body Weight at Birth and Beyond: A Review of Animal and Human Studies.Q49971656
Disruption of adult olfactory neurogenesis induces deficits in maternal behavior in sheepQ50421031
Prenatal exposure to selective serotonin reuptake inhibitors (SSRI) increases aggression and modulates maternal behavior in offspring mice.Q50564730
The reproductive stage and experience of sexually receptive mothers alter their preference for pups or males.Q50631528
Oxytocin receptors in the nucleus accumbens shell are involved in the consolidation of maternal memory in postpartum rats.Q51034661
Inhibitory effect of buspirone and diazepam, but not of 8-OH-DPAT, on maternal behavior and aggression.Q51393082
Ethopharmacology of maternal aggression in mice: effects of diazepam and SM-3997Q51708974
Cerebrospinal fluid concentration of 5-hydroxyindoleactic acid in pregnancy.Q51831721
Sex differences in expression of serotonin receptors (subtypes 1A and 2A) in rat brain: a possible role of testosterone.Q51978956
Intergenerational transmission of maternal behavior in rhesus macaques and its underlying mechanisms.Q51994412
Differential susceptibility in spillover between interparental conflict and maternal parenting practices: evidence for OXTR and 5-HTT genesQ36010719
Distribution and excretion of fluoxetine and norfluoxetine in human milkQ36053901
The effects of gestational stress and Selective Serotonin reuptake inhibitor antidepressant treatment on structural plasticity in the postpartum brain--A translational model for postpartum depressionQ36296964
Hippocampal neurogenesis: regulation by stress and antidepressantsQ36517215
Maternal antidepressant use and adverse outcomes: a cohort study of 228,876 pregnanciesQ36596080
Serotonin 1A receptor reductions in postpartum depression: a positron emission tomography studyQ36696405
Serotonin (5-HT) 5-HT2A Receptor (5-HT2AR):5-HT2CR Imbalance in Medial Prefrontal Cortex Associates with Motor Impulsivity.Q36738073
Structure and function of the brain serotonin systemQ36741599
Antenatal maternal stress and long-term effects on child neurodevelopment: how and why?Q36758630
Effects of noradrenergic alpha-2 receptor antagonism or noradrenergic lesions in the ventral bed nucleus of the stria terminalis and medial preoptic area on maternal care in female ratsQ36838912
The effects of maternal depression and maternal selective serotonin reuptake inhibitor exposure on offspringQ36860205
Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parentingQ36913209
Linking emotion to the social brain. The role of the serotonin transporter in human social behaviour.Q36921921
Serotoninergic regulation of emotional and behavioural control processesQ37028037
The birth of new neurons in the maternal brain: Hormonal regulation and functional implications.Q37088644
Social instigation and aggression in postpartum female rats: role of 5-Ht1A and 5-Ht1B receptors in the dorsal raphé nucleus and prefrontal cortexQ37105476
Pregnant rats show enhanced spatial memory, decreased anxiety, and altered levels of monoaminergic neurotransmittersQ37120380
Medial preoptic area interactions with dopamine neural systems in the control of the onset and maintenance of maternal behavior in ratsQ37330735
Evaluation of two automated metrics for analyzing partner preference testsQ37354277
Depression during pregnancy: rates, risks and consequences--Motherisk Update 2008.Q37375765
Genetic Contributions of Inflammation to DepressionQ37483043
Perinatal depression: prevalence, risks, and the nutrition link--a review of the literatureQ37584684
Postnatal depression: a global public health perspectiveQ37605119
Adolescent exposure to anabolic/androgenic steroids and the neurobiology of offensive aggression: a hypothalamic neural model based on findings in pubertal Syrian hamstersQ37633050
Developmental changes in serotonin signaling: Implications for early brain function, behavior and adaptationQ37643389
New perspectives on the neurodevelopmental effects of SSRIsQ37645078
Sustained neurobehavioral effects of exposure to SSRI antidepressants during development: molecular to clinical evidenceQ37658594
Annual Research Review: All mothers are not created equal: neural and psychobiological perspectives on mothering and the importance of individual differencesQ37798288
Plasticity of the parental brain: a case for neurogenesisQ37913483
From stress to postpartum mood and anxiety disorders: how chronic peripartum stress can impair maternal adaptations.Q37951354
Serotonin and prefrontal cortex function: neurons, networks, and circuitsQ37955094
Serotonin and beyond: therapeutics for major depressionQ38084600
New theoretical and experimental approaches on maternal motivation in mammalsQ38100870
Distribution and cellular localization of mRNA coding for 5-HT1A receptor in the rat brain: correlation with receptor binding.Q38330752
P304page(s)100742
P577publication date2019-03-13
P1433published inFrontiers in NeuroendocrinologyQ15716620
P1476titleSerotonin and motherhood: From molecules to mood
P478volume53

Reverse relations

cites work (P2860)
Q92442387Beyond the baby brain: Moving towards a better understanding of the parental brain and behavior
Q83601013ErbB4 knockdown in serotonergic neurons in the dorsal raphe induces anxiety-like behaviors
Q100513948How Stress can Influence Brain Adaptations to Motherhood
Q98200229Perinatal Depression: Heterogeneity of Disease and in Animal Models
Q92574489The behavioral neuroendocrinology of maternal behavior: Past accomplishments and future directions

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