Skin Barrier and Autoimmunity-Mechanisms and Novel Therapeutic Approaches for Autoimmune Blistering Diseases of the Skin

scientific article published on 14 May 2019

Skin Barrier and Autoimmunity-Mechanisms and Novel Therapeutic Approaches for Autoimmune Blistering Diseases of the Skin is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3389/FIMMU.2019.01089
P932PMC publication ID6530337
P698PubMed publication ID31156638

P50authorAllison J. CowinQ38800671
Natalie E StevensQ56872628
Zlatko KopeckiQ61155102
P2860cites workLong-term remissions of severe pemphigus after rituximab therapy are associated with prolonged failure of desmoglein B cell response.Q50910869
Pivotal Role of Lesional and Perilesional T/B Lymphocytes in Pemphigus Pathogenesis.Q50925874
CD4+CD25high regulatory T cells are markedly decreased in blood of patients with pemphigus vulgaris.Q51041309
A randomized double-blind trial of intravenous immunoglobulin for bullous pemphigoid.Q51051272
Rituximab Treatment for Recalcitrant Dermatitis Herpetiformis.Q51230713
Topically Applied Hsp90 Blocker 17AAG Inhibits Autoantibody-Mediated Blister-Inducing Cutaneous Inflammation.Q51472998
Autoantibody Profile Differentiates between Inflammatory and Noninflammatory Bullous Pemphigoid.Q51636888
Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice.Q52332743
Pemphigus foliaceus IgG causes dissociation of desmoglein 1-containing junctions without blocking desmoglein 1 transinteractionQ24530223
Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease.Q24537348
Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal miceQ24564582
Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunityQ24669539
Cytoskeletal Regulation of Inflammation and Its Impact on Skin Blistering Disease Epidermolysis Bullosa AcquisitaQ26740099
The Role of Damage-Associated Molecular Patterns in Human Diseases: Part I - Promoting inflammation and immunityQ26864215
Black patients of African descent and HLA-DRB1*15:03 frequency overrepresented in epidermolysis bullosa acquisitaQ84742960
Up-regulation of CCL11 and CCL26 is associated with activated eosinophils in bullous pemphigoidQ85068810
Risk factors for bullous pemphigoid in the elderly: a prospective case-control studyQ85190909
British Association of Dermatologists' guidelines for the management of bullous pemphigoid 2012Q85344681
Topically applied flightless I neutralizing antibodies improve healing of blistered skin in a murine model of epidermolysis bullosa acquisitaQ85637843
Localized bullous pemphigoid occurring on surgical scarsQ86940956
Regulatory T-cell deficiency leads to pathogenic bullous pemphigoid antigen 230 autoantibody and autoimmune bullous diseaseQ88500454
The Role of Eosinophils in Bullous Pemphigoid: A Developing Model of Eosinophil Pathogenicity in Mucocutaneous DiseaseQ90455736
Case of autoimmune intraepidermal and subepidermal blistering disease in which autoantibodies to desmoglein 1 and BP230 coexistQ90483080
Therapeutic Effect of a Novel Phosphatidylinositol-3-Kinase δ Inhibitor in Experimental Epidermolysis Bullosa AcquisitaQ90534624
Association of Bullous Pemphigoid With Dipeptidyl-Peptidase 4 Inhibitors in Patients With Diabetes: Estimating the Risk of the New Agents and Characterizing the PatientsQ90846954
Dermatitis Herpetiformis and Celiac Disease Increase the Risk of Bullous PemphigoidQ90909224
IL-17A is functionally relevant and a potential therapeutic target in bullous pemphigoidQ91465395
Drug Discovery for Pemphigoid DiseasesQ91750461
Paraneoplastic pemphigus: a short reviewQ28077638
Autoimmunity against desmosomal cadherins in pemphigusQ28137910
The diagnosis and treatment of dermatitis herpetiformisQ28262298
A systematic review of eculizumab for atypical haemolytic uraemic syndrome (aHUS)Q28661698
Eosinophils in Autoimmune Diseases.Q33607031
Autoimmune blistering diseases in females: a reviewQ33640302
Mechanisms of Autoantibody-Induced Pathology.Q33740580
Correlation between IL36α and IL17 and Activity of the Disease in Selected Autoimmune Blistering DiseasesQ33762424
Frequency of Neurological Disorders in Bullous Pemphigoid Patients: A Cross-Sectional StudyQ33775465
Epitope spreading: protection from pathogens, but propagation of autoimmunity?Q34328092
Dermatitis herpetiformis: pathophysiology, clinical presentation, diagnosis and treatmentQ34504412
Persistent autoantibody-production by intermediates between short-and long-lived plasma cells in inflamed lymph nodes of experimental epidermolysis bullosa acquisitaQ35080528
Epidermolysis bullosa: directions for future research and new challenges for treatmentQ35099773
Nanorobotic investigation identifies novel visual, structural and functional correlates of autoimmune pathology in a blistering skin disease model.Q35242526
Environmental risk factors in endemic pemphigus foliaceus (fogo selvagem).Q35660724
Identification of a Functional Risk Variant for Pemphigus Vulgaris in the ST18 GeneQ36009248
Critical Role of the Neonatal Fc Receptor (FcRn) in the Pathogenic Action of Antimitochondrial Autoantibodies Synergizing with Anti-desmoglein Autoantibodies in Pemphigus VulgarisQ36093026
Three case reports of post immunization and post viral Bullous Pemphigoid: looking for the right triggerQ36287750
Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB/W miceQ36399066
Cell damage and autoimmunity: a critical appraisalQ36440448
Autoantibodies in the autoimmune disease pemphigus foliaceus induce blistering via p38 mitogen-activated protein kinase-dependent signaling in the skinQ37061072
T cell-independent B cell activation induces immunosuppressive sialylated IgG antibodies.Q37123859
Autoantibodies other than Anti-desmogleins in Pemphigus Vulgaris PatientsQ37618577
Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris.Q37685685
Long-lived autoreactive plasma cells drive persistent autoimmune inflammationQ37833902
Pemphigus autoimmunity: hypotheses and realitiesQ37937040
Current therapy of the pemphigus groupQ37964163
Where does rituximab fit in the treatment of autoimmune mucocutaneous blistering skin disease?Q38004882
Relationship between radiation therapy and bullous pemphigoidQ38214803
Malignancies in bullous pemphigoid: A controversial associationQ38598962
Immune mechanism-targeted treatment of experimental epidermolysis bullosa acquisita.Q38608315
Dramatic resolution of bullous pemphigoid after surgery for gastric cancer: A case reportQ38669806
Epidermolysis Bullosa Acquisita: From Pathophysiology to Novel Therapeutic Options.Q38695599
Three Cases of Bullous Pemphigoid Associated with Dipeptidyl Peptidase-4 Inhibitors - One due to Linagliptin.Q38714800
Increasing the Complement of Therapeutic Options in Bullous PemphigoidQ48516802
British Association of Dermatologists' guidelines for the management of pemphigus vulgaris 2017.Q49382688
Association between HLA-DQB1 polymorphisms and pemphigus vulgaris: A meta-analysis.Q49576144
HLA-DQB1*03:01 as a Biomarker for Genetic Susceptibility to Bullous Pemphigoid Induced by DPP-4 Inhibitors.Q50083924
Whole-Genome Expression Profiling in Skin Reveals SYK As a Key Regulator of Inflammation in Experimental Epidermolysis Bullosa Acquisita.Q50333828
High risk of death in elderly patients with extensive bullous pemphigoid.Q50894682
Update on the role of plasmacytoid dendritic cells in inflammatory/autoimmune skin diseasesQ38720050
Discovering potential drug-targets for personalized treatment of autoimmune disorders - what we learn from epidermolysis bullosa acquisita.Q38720806
Mechanisms of Disease: Pemphigus and Bullous Pemphigoid.Q38747187
Signalling and targeted therapy of inflammatory cells in epidermolysis bullosa acquisita.Q38749755
Plasma cells as an innovative target in autoimmune disease with renal manifestationsQ38753491
Infections associated with the use of eculizumab: recommendations for prevention and prophylaxisQ38852573
First-line rituximab combined with short-term prednisone versus prednisone alone for the treatment of pemphigus (Ritux 3): a prospective, multicentre, parallel-group, open-label randomised trialQ38876705
Clinical features and diagnosis of epidermolysis bullosa acquisitaQ38942490
Bullous pemphigoid autoantibodies directly induce blister formation without complement activationQ38952869
Biologics for Targeting Inflammatory Cytokines, Clinical Uses, and Limitations.Q39084627
IL-17 and IL-22 in immunity: Driving protection and pathologyQ39179415
Rituximab combined with conventional therapy versus conventional therapy alone for the treatment of mucous membrane pemphigoid (MMP).Q39952624
Autoantibodies to type VII collagen mediate Fcgamma-dependent neutrophil activation and induce dermal-epidermal separation in cryosections of human skinQ40719797
Development of chimeric molecules for recognition and targeting of antigen-specific B cells in pemphigus vulgarisQ40772545
Analysis of Serum Cytokine Profile in PemphigusQ40955447
Pemphigus vulgaris-IgG causes a rapid depletion of desmoglein 3 (Dsg3) from the Triton X-100 soluble pools, leading to the formation of Dsg3-depleted desmosomes in a human squamous carcinoma cell line, DJM-1 cellsQ40981530
Caspase-1-independent IL-1 release mediates blister formation in autoantibody-induced tissue injury through modulation of endothelial adhesion moleculesQ41184705
Neurological disorders in patients with bullous pemphigoid: clinical and experimental investigationsQ41479818
Transforming growth factor-beta up-regulates type VII collagen gene expression in normal and transformed epidermal keratinocytes in cultureQ41660060
Regulatory T cells as well as IL-10 are reduced in the skin of patients with dermatitis herpetiformis.Q41736822
A possible role for CD8+ T lymphocytes in the cell-mediated pathogenesis of pemphigus vulgarisQ41952852
Association of bullous pemphigoid with malignancy: a myth or reality?Q42073366
Cutting Edge: Brazilian pemphigus foliaceus anti-desmoglein 1 autoantibodies cross-react with sand fly salivary LJM11 antigenQ42261879
Reduced skin blistering in experimental epidermolysis bullosa acquisita after anti-TNF treatmentQ42320550
T cells mediate autoantibody-induced cutaneous inflammation and blistering in epidermolysis bullosa acquisitaQ42358830
Refractory pemphigus foliaceus associated with herpesvirus infection: case reportQ42369499
The immune response to secondary necrotic cells.Q42371859
A case of paraneoplastic bullous pemphigoid in association with squamous cell carcinoma of lungQ42423746
Transforming growth factor-beta promotes deposition of collagen VII in a modified organotypic skin model.Q42499160
The pathophysiology of autoimmune blistering diseasesQ42710748
Induction of epidermolysis bullosa acquisita in mice by passive transfer of autoantibodies from patientsQ43905705
Development of pemphigus herpetiformis in a patient with psoriasis receiving UV-light treatmentQ44789646
GM-CSF modulates autoantibody production and skin blistering in experimental epidermolysis bullosa acquisitaQ44811602
Two distinct viral infections complicating pemphigus foliaceus.Q45096604
B cells, dendritic cells, and macrophages are required to induce an autoreactive CD4 helper T cell response in experimental epidermolysis bullosa acquisitaQ45397909
Regulatory T Cells Suppress Inflammation and Blistering in Pemphigoid DiseasesQ46244253
Calcitriol Treatment Ameliorates Inflammation and Blistering in Mouse Models of Epidermolysis Bullosa Acquisita.Q46301824
The Anti-C1s Antibody TNT003 Prevents Complement Activation in the Skin Induced by Bullous Pemphigoid Autoantibodies.Q46401885
Evidence for a role of eosinophils in blister formation in bullous pemphigoidQ46425853
Langerhans Cells Prevent Autoimmunity via Expansion of Keratinocyte Antigen-Specific Regulatory T Cells.Q47200811
Dermatologic Reactions to Immune Checkpoint Inhibitors : Skin Toxicities and Immunotherapy.Q47277879
Eosinophils mediate tissue injury in autoimmune skin disease bullous pemphigoidQ47287873
Association of HLA class I and class II alleles with bullous pemphigoid in Chinese HansQ47297269
Type I regulatory T cells specific for desmoglein 3 are more frequently detected in healthy individuals than in patients with pemphigus vulgarisQ47643831
Autoimmune Subepidermal Bullous Diseases of the Skin and Mucosae: Clinical Features, Diagnosis, and ManagementQ47988514
Dermatitis herpetiformis: a cutaneous manifestation of coeliac diseaseQ48028538
The Role of Mast Cells in Autoimmune Bullous Dermatoses.Q52655233
T cell participation in autoreactivity to NC16a epitopes in bullous pemphigoid.Q52996461
Association of Bullous Pemphigoid and Malignant Neoplasms.Q53620287
Bullous pemphigoid associated with chronic hepatitis C virus infection in a hepatitis B virus endemic area: A case report.Q54092393
Increased Serum Levels of Th2-type Cytokines and Eotaxin in Fibrillar-type Dermatitis Herpetiformis.Q54148911
B Cell Modulation Strategies in Autoimmune Diseases: New Concepts.Q54980047
The Autoimmune Skin Disease Bullous Pemphigoid: The Role of Mast Cells in Autoantibody-Induced Tissue Injury.Q55104920
Autoantibody Signaling in Pemphigus Vulgaris: Development of an Integrated Model.Q55110690
Humoral Epitope Spreading in Autoimmune Bullous Diseases.Q55262188
Non-Desmoglein Antibodies in Patients With Pemphigus Vulgaris.Q55375191
Autoimmune Diseases and Their Manifestations on Oral Cavity: Diagnosis and Clinical Management.Q55413268
Emerging treatment options for the management of pemphigus vulgaris.Q55433740
Regulatory T-cell deficiency and autoimmune skin disease: Beyond the scurfy mouse and immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndromeQ56963556
Mucous Membrane Pemphigoid, Bullous Pemphigoid, and Anti-programmed Death-1/ Programmed Death-Ligand 1: A Case Report of an Elderly Woman With Mucous Membrane Pemphigoid Developing After Pembrolizumab Therapy for Metastatic Melanoma and Review of theQ57490881
Identification of Quantitative Trait Loci in Experimental Epidermolysis Bullosa AcquisitaQ57836499
The Growing Incidence of Bullous Pemphigoid: Overview and Potential ExplanationsQ58735688
Comorbidities and Treatment Strategies in Bullous Pemphigoid: An Appraisal of the Existing LitteratureQ58764804
The Genetics of Pemphigus VulgarisQ58781495
Diagnosis of Autoimmune Blistering DiseasesQ59132166
Perspective From the 5th International Pemphigus and Pemphigoid Foundation Scientific ConferenceQ59341201
Complement-Activating Capacity of Autoantibodies Correlates With Disease Activity in Bullous Pemphigoid PatientsQ59791456
Demonstration of Epitope-Spreading Phenomena in Bullous Pemphigoid: Results of a Prospective Multicenter StudyQ60240341
Epidermolysis Bullosa Acquisita: The 2019 UpdateQ61449510
The Diagnosis and Blistering Mechanisms of Mucous Membrane PemphigoidQ61810264
Bullous pemphigoid associated with radiotherapy for esophageal carcinomaQ70175807
Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the diseaseQ70227278
Distribution of HLA class II alleles in Korean patients with epidermolysis bullosa acquisitaQ71970770
Immune modulation in pemphigus vulgaris: role of CD28 and IL-10Q73289709
Inflammatory variant of epidermolysis bullosa acquisita with IgG autoantibodies against type VII collagen and laminin alpha3Q73454179
Suction blister model of wound healingQ73571221
Epitope spreading in paraneoplastic pemphigus: autoimmune induction in antibody-mediated blistering skin diseasesQ73803284
Electron microscopy and morphometry enhances differentiation of epidermolysis bullosa subtypes. With normal values for 24 parameters in skinQ74096946
The anti-desmoglein 1 autoantibodies in pemphigus vulgaris sera are pathogenicQ77419396
Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokinesQ79747218
The alternative pathway of complement activation is critical for blister induction in experimental epidermolysis bullosa acquisitaQ80257413
Treatment of recalcitrant pemphigus vulgaris with the tumor necrosis factor alpha antagonist etanerceptQ81026380
Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: roles of IL-2 versus IL-15Q81239549
Radiation therapy as a trigger factor for initially localized bullous pemphigoidQ81502830
IgG from patients with bullous pemphigoid depletes cultured keratinocytes of the 180-kDa bullous pemphigoid antigen (type XVII collagen) and weakens cell attachmentQ83258289
Heat-shock protein 90 inhibition in autoimmunity to type VII collagen: evidence that nonmalignant plasma cells are not therapeutic targetsQ83853686
Antigen-independent development of Foxp3+ regulatory T cells suppressing autoantibody production in experimental pemphigus vulgarisQ83984319
Autoimmune diseases of the skinQ84072261
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P921main subjectskinQ1074
autoimmunityQ192360
epidermisQ212743
blisterQ276469
P304page(s)1089
P577publication date2019-05-14
P1433published inFrontiers in ImmunologyQ27723748
P1476titleSkin Barrier and Autoimmunity-Mechanisms and Novel Therapeutic Approaches for Autoimmune Blistering Diseases of the Skin
P478volume10

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cites work (P2860)
Q90266059Autoimmunity (or Not) in Atopic Dermatitis
Q90283161Monoclonal Antibodies in Dermatooncology-State of the Art and Future Perspectives

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