Ratiometric two-photon microscopy reveals attomolar copper buffering in normal and Menkes mutant cells

scientific article published on 03 June 2019

Ratiometric two-photon microscopy reveals attomolar copper buffering in normal and Menkes mutant cells is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2019PNAS..11612167M
P356DOI10.1073/PNAS.1900172116
P932PMC publication ID6589653
P698PubMed publication ID31160463

P50authorJenifer CalvoQ39184654
Victor FaundezQ43172297
Gabriele MeloniQ55948458
Stephanie A ZlaticQ63709843
Michael Thomas MorganQ85781746
Christoph J FahrniQ89048045
P2093author name stringDaisy Bourassa
Adam M McCallum
Shefali Harankhedkar
P2860cites workSynthetic fluorescent probes for studying copper in biological systemsQ27008520
Molecular basis of neurodegeneration and neurodevelopmental defects in Menkes diseaseQ28088624
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ATP7A-related copper transport diseases-emerging concepts and future trendsQ28302938
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Role of glutaredoxin1 and glutathione in regulating the activity of the copper-transporting P-type ATPases, ATP7A and ATP7B.Q34094489
An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII.Q35657769
Copper(II)-Bis(Thiosemicarbazonato) Complexes as Antibacterial Agents: Insights into Their Mode of Action and Potential as Therapeutics.Q36075898
Synthetic fluorescent probes for monovalent copperQ37174001
Rational Design of a Water-Soluble, Lipid-Compatible Fluorescent Probe for Cu(I) with Sub-Part-Per-Trillion Sensitivity.Q37546112
Mechanisms for activating Cu- and Zn-containing superoxide dismutase in the absence of the CCS Cu chaperoneQ37646146
Human copper homeostasis: a network of interconnected pathways.Q37684520
Robust affinity standards for Cu(I) biochemistryQ37697977
Molecular recognition in copper traffickingQ37742474
What has fluorescent sensing told us about copper and brain malfunction?Q38271378
Stepwise copper(i) binding to metallothionein: a mixed cooperative and non-cooperative mechanism for all 20 copper ions.Q38807379
Increasing intracellular bioavailable copper selectively targets prostate cancer cellsQ39154737
Cellular copper homeostasis: current concepts on its interplay with glutathione homeostasis and its implication in physiology and human diseasesQ39413241
Orchestration of dynamic copper navigation - new and missing piecesQ39420445
Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes.Q39481150
Dynamic multibody protein interactions suggest versatile pathways for copper trafficking.Q42135446
Uptake and efflux of copper-64 in Menkes'-disease and normal continuous lymphoid cell linesQ42164628
Redox sulfur chemistry of the copper chaperone Atox1 is regulated by the enzyme glutaredoxin 1, the reduction potential of the glutathione couple GSSG/2GSH and the availability of Cu(I).Q42706883
Genetically encoded copper(I) reporters with improved response for use in imagingQ45734289
Generation of superoxide radicals by copper-glutathione complexes: redox-consequences associated with their interaction with reduced glutathioneQ46115700
Glutathione limits aquacopper(I) to sub-femtomolar concentrations through cooperative assembly of a tetranuclear cluster.Q46269181
Transfer of copper between bis(thiosemicarbazone) ligands and intracellular copper-binding proteins. insights into mechanisms of copper uptake and hypoxia selectivityQ46644976
Copper-treatment increases the cellular GSH content and accelerates GSH export from cultured rat astrocytesQ46821030
Rational design of reversible fluorescent probes for live-cell imaging and quantification of fast glutathione dynamicsQ48825635
Metallothionein accumulation may account for intracellular copper retention in Menkes' diseaseQ48953620
Chromis-1, a Ratiometric Fluorescent Probe Optimized for Two-Photon Microscopy Reveals Dynamic Changes in Labile Zn(II) in Differentiating OligodendrocytesQ50067710
The role of glutathione in copper metabolism and toxicity.Q54355596
Induction of Neuronal Apoptosis by Thiol OxidationQ59393048
Copper trafficking mechanism of CXXC-containing domains: insight from the pH-dependence of their Cu(I) affinitiesQ83416284
Stabilization of Aliphatic Phosphines by Auxiliary Phosphine Sulfides Offers Zeptomolar Affinity and Unprecedented Selectivity for Probing Biological CuIQ89048047
Non-coordinative metal selectivity bias in human metallothioneins metal-thiolate clustersQ93020367
P433issue25
P304page(s)12167-12172
P577publication date2019-06-03
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleRatiometric two-photon microscopy reveals attomolar copper buffering in normal and Menkes mutant cells
P478volume116

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cites work (P2860)
Q97692611Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer
Q99731027Getting out what you put in: copper in mitochondria and its impacts on human disease
Q90425891High-affinity Cu(I) chelator PSP-2 as potential anti-angiogenic agent

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