| P50 | author | Brian R Effer | Q83261275 |
| P2093 | author name string | Adalberto Pessoa | |
| | Rodrigo L Castillo | |
| | Jorge G Farías | |
| | Lisandra Herrera Belén | |
| | Manuel Lee-Estevez | |
| | Carlota de Oliveira Rangel-Yagui | |
| | Jorge F Beltrán Lissabet | |
| P2860 | cites work | Transglutaminases: nature's biological glues | Q24534936 |
| | Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesin | Q24610696 |
| | One-step site-specific modification of native proteins with 2-pyridinecarboxyaldehydes | Q35590287 |
| | A peptide N-terminal protection strategy for comprehensive glycoproteome analysis using hydrazide chemistry based method | Q35591012 |
| | Chemical and biological properties of polymer-modified proteins | Q35594076 |
| | The design and development of pegfilgrastim (PEG-rmetHuG-CSF, Neulasta). | Q35743530 |
| | Transglutaminases as biotechnological tools. | Q36061316 |
| | Chemical tagging and customizing of cellular chromatin states using ultrafast trans-splicing inteins | Q36198433 |
| | Protein-polymer conjugation-moving beyond PEGylation | Q36220152 |
| | Isoform separation and structural identification of mono-PEGylated recombinant human growth hormone (PEG-rhGH) with pH gradient chromatography. | Q36268366 |
| | Selective N-terminal functionalization of native peptides and proteins. | Q36383973 |
| | Correlation between sequence hydrophobicity and surface-exposure pattern of database proteins | Q36526506 |
| | Safety of PEGylated recombinant human full-length coagulation factor VIII (BAX 855) in the overall context of PEG and PEG conjugates | Q36533097 |
| | Pharmacokinetic consequences of pegylation | Q36604526 |
| | Well-defined protein-polymer conjugates--synthesis and potential applications. | Q36633118 |
| | Enhanced thermal stability of lichenase from Bacillus subtilis 168 by SpyTag/SpyCatcher-mediated spontaneous cyclization | Q36748943 |
| | Click chemistry, a powerful tool for pharmaceutical sciences | Q36925524 |
| | Imaging proteins in live mammalian cells with biotin ligase and monovalent streptavidin | Q37164001 |
| | Peptide/protein-polymer conjugates: synthetic strategies and design concepts. | Q37184093 |
| | PEGylation of Octreotide Using an α,β-unsaturated-β'-mono-sulfone Functionalized PEG Reagent | Q37268196 |
| | Sortase-mediated ligation: a gift from Gram-positive bacteria to protein engineering. | Q37387169 |
| | Site-specific PEGylation enhances the pharmacokinetic properties and antitumor activity of interferon beta-1b. | Q37404242 |
| | A Nanobody Activation Immunotherapeutic that Selectively Destroys HER2-Positive Breast Cancer Cells | Q37544893 |
| | PEGylation of therapeutic proteins | Q37673091 |
| | SpyLigase peptide-peptide ligation polymerizes affibodies to enhance magnetic cancer cell capture | Q37687557 |
| | Making and breaking peptide bonds: protein engineering using sortase | Q37871538 |
| | Pegloticase: in treatment-refractory chronic gout | Q37950519 |
| | Red blood cell-encapsulated L-asparaginase: potential therapy of patients with asparagine synthetase deficient acute myeloid leukemia | Q38046895 |
| | Versatility of microbial transglutaminase | Q38201525 |
| | Biotechnological applications of transglutaminases | Q38223682 |
| | Enzymatic formation of PEGylated oligonucleotides | Q38309559 |
| | SpyRing interrogation: analyzing how enzyme resilience can be achieved with phytase and distinct cyclization chemistries | Q38333947 |
| | Advances in chemical protein modification. | Q38362866 |
| | Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation. | Q38497871 |
| | Noncovalent PEGylation, An Innovative Subchapter in the Field of Protein Modification | Q38622244 |
| | What NMR can do in the biopharmaceutical industry | Q38651138 |
| | Noncovalent pegylation by dansyl-poly(ethylene glycol)s as a new means against aggregation of salmon calcitonin. | Q50543720 |
| | PEGylation and HAylation via catechol: α-Amine-specific reaction at N-terminus of peptides and proteins. | Q50784016 |
| | Versatile and Efficient Site-Specific Protein Functionalization by Tubulin Tyrosine Ligase. | Q50931802 |
| | An open-label, randomized, multicenter dose-finding study of once-per-cycle pegfilgrastim versus daily filgrastim in Chinese breast cancer patients receiving TAC chemotherapy. | Q51039067 |
| | Butelase-mediated cyclization and ligation of peptides and proteins. | Q51156538 |
| | Precise and combinatorial PEGylation generates a low-immunogenic and stable form of human growth hormone. | Q51164527 |
| | Characterization of a PEGylated protein therapeutic by ion exchange chromatography with on-line detection by native ESI MS and MS/MS. | Q51268017 |
| | Stability Enhancing N-Terminal PEGylation of Oxytocin Exploiting Different Polymer Architectures and Conjugation Approaches. | Q51639980 |
| | Correlations between in vitro potency of polyethylene glycol-protein conjugates and their chromatographic behavior. | Q51755119 |
| | Bioresponsive release of insulin-like growth factor-I from its PEGylated conjugate. | Q52720322 |
| | A dimeric form of a small-sized protein binder exhibits enhanced anti-tumor activity through prolonged blood circulation. | Q53071205 |
| | Site-specific attachment of polyethylene glycol-like oligomers to proteins and peptides. | Q53588388 |
| | Rapid analysis of protein expression and solubility with the SpyTag-SpyCatcher system. | Q54259867 |
| | Effects of polyethylene glycol attachment on physicochemical and biological stability of E. coli L-asparaginase. | Q54547280 |
| | Molecular dynamics simulation for rational protein engineering: Present and future prospectus | Q57164885 |
| | RAFT and click chemistry: A versatile approach to well-defined block copolymers | Q57370403 |
| | Bio-Click Chemistry: Enzymatic Functionalization of PEGylated Capsules for Targeting Applications | Q57644972 |
| | Decoration of virus-like particles with an enzymatic activity of biomedical interest | Q59357779 |
| | Post-PEGylated and crosslinked polymeric ssRNA nanocomplexes as adjuvants targeting lymph nodes with increased cytolytic T cell inducing properties | Q60506903 |
| | Chemical and Enzymatic Site Specific PEGylation of hGH | Q63973073 |
| | Multivalent and Flexible PEG-Nitrilotriacetic Acid Derivatives for Non-covalent Protein Pegylation | Q63973078 |
| | Structural similarity, characterization of Poly Ethylene Glycol linkage and identification of product related variants in biosimilar pegfilgrastim | Q64099653 |
| | Novel site-specific PEGylated L-asparaginase | Q64238386 |
| | Site-specific attachment of functionalized poly(ethylene glycol) to the amino terminus of proteins | Q71350155 |
| | Pegaspargase (Oncaspar) | Q72637958 |
| | N-terminal site-specific mono-PEGylation of epidermal growth factor | Q73403320 |
| | Amino acid preferences of small, naturally occurring polypeptides | Q73459264 |
| | Oxidative amide synthesis and N-terminal alpha-amino group ligation of peptides in aqueous medium | Q79358982 |
| | Pharmacokinetics and pharmacodynamics of intravenous and subcutaneous continuous erythropoietin receptor activator (C.E.R.A.) in patients with chronic kidney disease | Q80797186 |
| | Clinical trial: single- and multiple-dose pharmacokinetics of polyethylene glycol (PEG-3350) in healthy young and elderly subjects | Q81230702 |
| | Secrets of a covalent interaction for biomaterials and biotechnology: SpyTag and SpyCatcher | Q26777797 |
| | Site-Specific PEGylation of Therapeutic Proteins | Q26777819 |
| | Microbial enzymes: tools for biotechnological processes | Q26827731 |
| | Structure of a PEGylated protein reveals a highly porous double-helical assembly | Q27702190 |
| | N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins | Q27932762 |
| | A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes | Q28219495 |
| | Butelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesis | Q28244237 |
| | Adding new chemistries to the genetic code | Q28277278 |
| | Molecular insight into the steric shielding effect of PEG on the conjugated staphylokinase: biochemical characterization and molecular dynamics simulation | Q28534725 |
| | Glossary of basic terms in polymer science (IUPAC Recommendations 1996) | Q29301984 |
| | Assessment of the structure of pegylated-recombinant protein therapeutics by the NMR fingerprint assay | Q30399378 |
| | Click-PEGylation - A mobility shift approach to assess the redox state of cysteines in candidate proteins | Q30400582 |
| | A new site-specific monoPEGylated filgrastim derivative prepared by enzymatic conjugation: Production and physicochemical characterization | Q30418553 |
| | A stable three-enzyme creatinine biosensor. 1. Impact of structure, function and environment on PEGylated and immobilized sarcosine oxidase | Q33243504 |
| | N-terminal labeling of proteins by the Pictet-Spengler reaction | Q33356306 |
| | Yeast display evolution of a kinetically efficient 13-amino acid substrate for lipoic acid ligase. | Q33513255 |
| | Protein myristoylation in health and disease | Q33631172 |
| | Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling | Q33694691 |
| | polyethylene glycol-conjugated adenosine deaminase (ADA) therapy provides temporary immune reconstitution to a child with delayed-onset ADA deficiency | Q33910797 |
| | PEGylation of bovine serum albumin using click chemistry for the application as drug carriers | Q34139643 |
| | Modification of N-terminal α-amino groups of peptides and proteins using ketenes | Q34144614 |
| | Pegylation: a novel process for modifying pharmacokinetics | Q34340198 |
| | Sortase-based bio-organic strategies for macromolecular synthesis | Q34433182 |
| | Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization | Q34509612 |
| | A randomized, non-inferiority study comparing efficacy and safety of a single dose of pegfilgrastim versus daily filgrastim in pediatric patients after autologous peripheral blood stem cell transplant | Q34544831 |
| | Chemistry for peptide and protein PEGylation | Q34674747 |
| | Enzymatic procedure for site-specific pegylation of proteins | Q34674760 |
| | Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications | Q34674780 |
| | Labeling proteins with fluorophore/thioamide Förster resonant energy transfer pairs by combining unnatural amino acid mutagenesis and native chemical ligation | Q34675294 |
| | Effects of PEGylation on the physicochemical properties and in vivo distribution of organic nanotubes | Q34731969 |
| | Enzyme immunoassay and enzyme-linked immunosorbent assay. | Q34944805 |
| | Effect of pegylation on pharmaceuticals | Q35075776 |
| | N-terminal modification of proteins with o-aminophenols. | Q35157563 |
| | Two-step protein labeling utilizing lipoic acid ligase and Sonogashira cross-coupling | Q35230613 |
| | Pharmacokinetic/pharmacodynamic modeling of pegfilgrastim in healthy subjects | Q42689963 |
| | Leucyl/phenylalanyl(L/F)-tRNA-protein transferase-mediated aminoacyl transfer of a nonnatural amino acid to the N-terminus of peptides and proteins and subsequent functionalization by bioorthogonal reactions | Q42832088 |
| | Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition | Q43213727 |
| | Controlled branching of polyglycidol and formation of protein-glycidol bioconjugates via a graft-from approach with "PEG-like" arms | Q43446911 |
| | Specific N-terminal protein labelling: use of FMDV 3C pro protease and native chemical ligation | Q43592924 |
| | Surface grafting of electrospun fibers using ATRP and RAFT for the control of biointerfacial interactions | Q44159221 |
| | PEGylation Enhances Mosquito-Larvicidal Activity of Lysinibacillus sphaericus Binary Toxin. | Q44163292 |
| | Isolation, structural characterization, and antiviral activity of positional isomers of monopegylated interferon alpha-2a (PEGASYS). | Q44487898 |
| | A direct-infusion- and HPLC-ESI-Orbitrap-MS approach for the characterization of intact PEGylated proteins | Q44636842 |
| | Site-specific chemical modification of human serum albumin with polyethylene glycol prolongs half-life and improves intravascular retention in mice | Q44761246 |
| | Molecular Engineering of Acoustic Protein Nanostructures | Q44860339 |
| | Genetic encoding of caged cysteine and caged homocysteine in bacterial and mammalian cells. | Q44874415 |
| | Direct production of proteins with N-terminal cysteine for site-specific conjugation | Q44900286 |
| | Unambiguous characterization of N-glycans of monoclonal antibody cetuximab by integration of LC-MS/MS and ¹H NMR spectroscopy | Q45772599 |
| | PLA-PEG Coated Multifunctional Imaging Probe for Targeted Drug Delivery. | Q45972715 |
| | Site-Specific Radiofluorination of Biomolecules with 8-[(18)F]-Fluorooctanoic Acid Catalyzed by Lipoic Acid Ligase. | Q45999663 |
| | N-terminal protein modification through a biomimetic transamination reaction. | Q46092580 |
| | Transglutaminase-mediated PEGylation of proteins: direct identification of the sites of protein modification by mass spectrometry using a novel monodisperse PEG. | Q46136734 |
| | Characterization and stability of N-terminally PEGylated rhG-CSF. | Q46356414 |
| | Targeting the N terminus for site-selective protein modification | Q46463952 |
| | Tyrosine-selective protein alkylation using pi-allylpalladium complexes. | Q46469767 |
| | Surface reactions of 4-aminothiophenol with heterobifunctional crosslinkers bearing both succinimidyl ester and maleimide for biomolecular immobilization | Q46518537 |
| | Quantitative Detection of PEGylated Biomacromolecules in Biological Fluids by NMR. | Q46587991 |
| | PEGylation is effective in reducing immunogenicity, immunotoxicity, and hepatotoxicity of α-momorcharin in vivo. | Q46759580 |
| | Novel reagents for human prolactin research: large-scale preparation and characterization of prolactin receptor extracellular domain, non-pegylated and pegylated prolactin and prolactin receptor antagonist | Q47251978 |
| | Effects of polymer molecular weight on the size, activity, and stability of PEG-functionalized trypsin | Q47408008 |
| | MSAll strategy for comprehensive quantitative analysis of PEGylated-doxorubicin, PEG and doxorubicin by LC-high resolution q-q-TOF mass spectrometry coupled with all window acquisition of all fragment ion spectra | Q47814981 |
| | Designing Peptide and Protein Modified Hydrogels: Selecting the Optimal Conjugation Strategy | Q48177550 |
| | Noncovalent PEGylation through Protein-Polyelectrolyte Interaction: Kinetic Experiment and Molecular Dynamics Simulation. | Q48222020 |
| | Utilizing Selenocysteine for Expressed Protein Ligation and Bioconjugations | Q48252519 |
| | Proximity-Based Sortase-Mediated Ligation. | Q48324519 |
| | Characterization of singly and multiply PEGylated insulin isomers by reversed-phase ultra-performance liquid chromatography interfaced with ion mobility mass spectrometry. | Q50061489 |
| | Site-Specific N-Terminal Labeling of Peptides and Proteins using Butelase 1 and Thiodepsipeptide | Q50239317 |
| | Multisite clickable modification of proteins using lipoic acid ligase | Q50276239 |
| | Attribution of the discrepancy between ELISA and LC-MS/MS assay results of a PEGylated scaffold protein in post-dose monkey plasma samples due to the presence of anti-drug antibodies | Q82750367 |
| | Insights into the mechanism and catalysis of the native chemical ligation reaction | Q83355026 |
| | Effect of PEGylation on protein hydrodynamics | Q83482210 |
| | Continuous EPO receptor activator therapy of anemia in children under peritoneal dialysis | Q83642044 |
| | Noncovalent PEGylation: different effects of dansyl-, L-tryptophan-, phenylbutylamino-, benzyl- and cholesteryl-PEGs on the aggregation of salmon calcitonin and lysozyme | Q83742017 |
| | Solid-phase synthesis of PEGylated lipopeptides using click chemistry | Q84248415 |
| | Sensitive quantification of PEGylated compounds by second-generation anti-poly(ethylene glycol) monoclonal antibodies | Q84381308 |
| | Noncovalent PEGylation by polyanion complexation as a means to stabilize keratinocyte growth factor-2 (KGF-2) | Q85005694 |
| | Noncovalent PEGylation of L-asparaginase using PEGylated polyelectrolyte | Q85889801 |
| | N-Terminal α-amino group modification of peptides by an oxime formation-exchange reaction sequence | Q86991532 |
| | Protein derivitization-expressed protein ligation | Q87095555 |
| | Conjugate-base-stabilized Brønsted acids: catalytic enantioselective Pictet-Spengler reactions with unmodified tryptamine | Q87135879 |
| | Aldehyde capture ligation for synthesis of native peptide bonds | Q87293039 |
| | Quantitative analysis of polyethylene glycol (PEG) and PEGylated proteins in animal tissues by LC-MS/MS coupled with in-source CID | Q87365123 |
| | Recent progress in enzymatic protein labelling techniques and their applications | Q91801537 |
| | Determination of the degree of PEGylation of protein bioconjugates using data from proton nuclear magnetic resonance spectroscopy | Q92930858 |
| | Pharmacokinetics of 40 kDa PEG in rodents using high-field NMR spectroscopy | Q92931858 |
| | Characterization of PEGylated Asparaginase: New Opportunities from NMR Analysis of Large PEGylated Therapeutics | Q93270989 |
| | Chemical Protein Modification through Cysteine | Q38704033 |
| | PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs | Q38730623 |
| | Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications | Q38818237 |
| | Tumor Growth Inhibition via Occlusion of Tumor Vasculature Induced by N-Terminally PEGylated Retargeted Tissue Factor tTF-NGR. | Q38840536 |
| | Site-selective protein-modification chemistry for basic biology and drug development | Q38918179 |
| | Pharmacodynamics of peginterferon alpha-2a and peginterferon alpha-2b in interferon-naïve patients with chronic hepatitis C: a randomized, controlled study | Q38924180 |
| | How PEGylation influences protein conformational stability. | Q38942496 |
| | Enzyme-mediated ligation technologies for peptides and proteins | Q39147636 |
| | Protein cell-surface display through in situ enzymatic modification of proteins with a poly(Ethylene glycol)-lipid | Q39165087 |
| | Bioorthogonal copper-free click chemistry in vivo for tumor-targeted delivery of nanoparticles | Q39256568 |
| | SpyTag/SpyCatcher cyclization confers resilience to boiling on a mesophilic enzyme | Q39264891 |
| | Computational and nonglycosylated systems: a simpler approach for development of nanosized PEGylated proteins. | Q39267961 |
| | Extracellular Self-Assembly of Functional and Tunable Protein Conjugates from Bacillus subtilis | Q39303865 |
| | Direct peptide bioconjugation/PEGylation at tyrosine with linear and branched polymeric diazonium salts | Q39366016 |
| | Tryptophan-mPEGs: novel excipients that stabilize salmon calcitonin against aggregation by non-covalent PEGylation | Q39518447 |
| | Quantitative determination of pegylated consensus interferon in rhesus monkey serum using a competitive enzyme-linked immunosorbent assay | Q39782082 |
| | Large-Scale Biophysical Evaluation of Protein PEGylation Effects: In Vitro Properties of 61 Protein Entities | Q39864701 |
| | Enhanced solubility and stability of PEGylated liposomal paclitaxel: in vitro and in vivo evaluation | Q40157398 |
| | Protein PEGylation decreases observed target association rates via a dual blocking mechanism | Q40385511 |
| | Site-Specific Transglutaminase-Mediated Conjugation of Interferon α-2b at Glutamine or Lysine Residues. | Q40509438 |
| | Therapeutic proteins: a comparison of chemical and biological properties of uricase conjugated to linear or branched poly(ethylene glycol) and poly(N-acryloylmorpholine). | Q41758612 |
| | Genetic encoding of photocaged cysteine allows photoactivation of TEV protease in live mammalian cells | Q41791325 |
| | Site-specific biotinylation of purified proteins using BirA. | Q41874378 |
| | N-terminal specific conjugation of extracellular matrix proteins to 2-pyridinecarboxaldehyde functionalized polyacrylamide hydrogels | Q41879775 |
| | Characterization of the Conjugation Pattern in Large Polysaccharide-Protein Conjugates by NMR Spectroscopy. | Q41986522 |
| | Volume resuscitation from hemorrhagic shock with albumin and hexaPEGylated human serum albumin. | Q42578435 |
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P304 | page(s) | 1450 | |
| P577 | publication date | 2019-12-18 | |
| P1433 | published in | Frontiers in Pharmacology | Q2681208 |
| P1476 | title | From Synthesis to Characterization of Site-Selective PEGylated Proteins | |
| P478 | volume | 10 | |