| scholarly article | Q13442814 |
| P2093 | author name string | Eugene V Mosharov | |
| Oren A Levy | |||
| Lloyd A Greene | |||
| Lyudmila Kovalchuke | |||
| P2860 | cites work | PINK1 is selectively stabilized on impaired mitochondria to activate Parkin | Q21145802 |
| Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity | Q24290192 | ||
| Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65 | Q24292901 | ||
| Ubiquitin is phosphorylated by PINK1 to activate parkin | Q24296532 | ||
| Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity | Q24297369 | ||
| Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling | Q24297849 | ||
| The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy | Q24298748 | ||
| Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function | Q24298958 | ||
| Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival | Q24300743 | ||
| Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons | Q24305292 | ||
| Autoregulation of Parkin activity through its ubiquitin-like domain | Q24307382 | ||
| The role of oxidative stress in Parkinson's disease | Q24307946 | ||
| Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1 | Q24308897 | ||
| Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation | Q24312713 | ||
| ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin | Q24314995 | ||
| Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress | Q24320160 | ||
| The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO | Q24321825 | ||
| PARKIN overexpression in human mesenchymal stromal cells from Wharton's jelly suppresses 6-hydroxydopamine-induced apoptosis: Potential therapeutic strategy in Parkinson's disease. | Q46273034 | ||
| Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration. | Q46305258 | ||
| Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease | Q46310564 | ||
| Revisiting the reactions of superoxide with glutathione and other thiols | Q46561113 | ||
| Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function | Q46797053 | ||
| Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells | Q46975934 | ||
| Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy | Q47263209 | ||
| Activation mechanisms of the E3 ubiquitin ligase parkin | Q47732208 | ||
| Urate promotes SNCA/α-synuclein clearance via regulating mTOR-dependent macroautophagy | Q47934028 | ||
| Rotenone-induced parkinsonism elicits behavioral impairments and differential expression of parkin, heat shock proteins and caspases in the rat. | Q48468942 | ||
| Levodopa and 3-O-methyldopa in cerebrospinal fluid after levodopa-carbidopa association | Q48732841 | ||
| Building and decoding ubiquitin chains for mitophagy | Q49864965 | ||
| Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms. | Q52311011 | ||
| Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. | Q53821420 | ||
| Mechanism of parkin activation by phosphorylation | Q57266706 | ||
| The Cellular Protein Level of Parkin Is Regulated by Its Ubiquitin-like Domain | Q57371863 | ||
| Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease | Q57663621 | ||
| Mechanism of parkin activation by PINK1 | Q59057919 | ||
| Membrane accessibility of glutathione | Q60194866 | ||
| PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy. | Q64940992 | ||
| Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro | Q67016091 | ||
| Prevention of dopamine-induced cell death by thiol antioxidants: possible implications for treatment of Parkinson's disease. | Q67228281 | ||
| Temporal relationships between plasma and cerebrospinal fluid pharmacokinetics of levodopa and clinical effect in Parkinson's disease | Q67924731 | ||
| Dopamine- and L-beta-3,4-dihydroxyphenylalanine hydrochloride (L-Dopa)-induced cytotoxicity towards catecholaminergic neuroblastoma SH-SY5Y cells. Effects of oxidative stress and antioxidative factors | Q73145088 | ||
| Caspase-1 and caspase-8 cleave and inactivate cellular parkin | Q73262534 | ||
| Glia protect fetal midbrain dopamine neurons in culture from L-DOPA toxicity through multiple mechanisms | Q73692009 | ||
| Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells: involvement of hydrogen peroxide-dependent and -independent action | Q79755319 | ||
| Mitochondrial dysfunction in Parkinson's disease | Q88170868 | ||
| Apoptosis-inducing neurotoxicity of dopamine and its metabolites via reactive quinone generation in neuroblastoma cells | Q44258769 | ||
| Alteration of 8-hydroxyguanosine concentrations in the cerebrospinal fluid and serum from patients with Parkinson's disease | Q44260283 | ||
| Parkin gene therapy for alpha-synucleinopathy: a rat model of Parkinson's disease | Q45881923 | ||
| Dopamine covalently modifies and functionally inactivates parkin | Q24338423 | ||
| Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy | Q24339224 | ||
| Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor | Q24561804 | ||
| Catecholamine autotoxicity. Implications for pharmacology and therapeutics of Parkinson disease and related disorders | Q26826093 | ||
| Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering | Q27311602 | ||
| Cell-permeable parkin proteins suppress Parkinson disease-associated phenotypes in cultured cells and animals | Q27318797 | ||
| Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin | Q27320529 | ||
| A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease | Q27678628 | ||
| OPA1 processing in cell death and disease - the long and short of it | Q28073543 | ||
| Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control | Q28114972 | ||
| Parkin is protective against proteotoxic stress in a transgenic zebrafish model | Q28474988 | ||
| The diabetes susceptibility gene Clec16a regulates mitophagy | Q28511990 | ||
| Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation | Q28830194 | ||
| Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin | Q29615623 | ||
| PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy | Q29616005 | ||
| PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity | Q29617292 | ||
| PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65 | Q29622844 | ||
| The effects of oxidative stress on parkin and other E3 ligases | Q30273796 | ||
| The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity | Q30846938 | ||
| Parkin and mitochondrial quality control: toward assembling the puzzle | Q33357691 | ||
| Metabolism and functions of glutathione in brain. | Q33908238 | ||
| Small, N-terminal tags activate Parkin E3 ubiquitin ligase activity by disrupting its autoinhibited conformation. | Q34230329 | ||
| PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding | Q34322599 | ||
| Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease | Q34577087 | ||
| Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis. | Q34622632 | ||
| USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin | Q34815182 | ||
| Ubiquitination increases parkin activity to promote autophagic α-synuclein clearance | Q35080740 | ||
| Biochemical and toxicological properties of the oxidation products of catecholamines | Q35379586 | ||
| Chemogenomic profiling of endogenous PARK2 expression using a genome-edited coincidence reporter | Q35562659 | ||
| Tyrosine hydroxylase is short-term regulated by the ubiquitin-proteasome system in PC12 cells and hypothalamic and brainstem neurons from spontaneously hypertensive rats: possible implications in hypertension | Q35566854 | ||
| Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy. | Q35669194 | ||
| Trib3 Is Elevated in Parkinson's Disease and Mediates Death in Parkinson's Disease Models | Q35897729 | ||
| Recovery of hypothalamic tuberoinfundibular dopamine neurons from acute toxicant exposure is dependent upon protein synthesis and associated with an increase in parkin and ubiquitin carboxy-terminal hydrolase-L1 expression | Q35997646 | ||
| (Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation | Q36078552 | ||
| ??? | Q64770076 | ||
| A Ubl/ubiquitin switch in the activation of Parkin | Q36172257 | ||
| PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy | Q36476931 | ||
| The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation | Q36636158 | ||
| Complexity of dopamine metabolism. | Q36958208 | ||
| Declines in Drp1 and parkin expression underlie DNA damage-induced changes in mitochondrial length and neuronal death. | Q37014103 | ||
| CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins | Q37021183 | ||
| Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons | Q37180671 | ||
| Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps | Q37376117 | ||
| Parkin plays a role in sporadic Parkinson's disease | Q37699241 | ||
| Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease | Q37713838 | ||
| Renal membrane transport of glutathione in toxicology and disease. | Q37775429 | ||
| Milestones in PD genetics | Q37882589 | ||
| L-DOPA: a scapegoat for accelerated neurodegeneration in Parkinson's disease? | Q37896951 | ||
| Autosomal recessive parkinsonism | Q37968072 | ||
| The prevalence of Parkinson's disease: a systematic review and meta-analysis | Q38224356 | ||
| Levodopa: effect on cell death and the natural history of Parkinson's disease | Q38287219 | ||
| Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity | Q38576138 | ||
| Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy. | Q38656442 | ||
| Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity | Q38834612 | ||
| NAC1, A POZ/BTB protein interacts with Parkin and may contribute to Parkinson's disease | Q39063122 | ||
| The pharmacological regulation of cellular mitophagy. | Q39095156 | ||
| Phosphorylated ubiquitin chain is the genuine Parkin receptor. | Q39589823 | ||
| Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients | Q39699315 | ||
| Formation of parkin aggregates and enhanced PINK1 accumulation during the pathogenesis of Parkinson's disease | Q39737193 | ||
| The serine protease HtrA2/Omi cleaves Parkin and irreversibly inactivates its E3 ubiquitin ligase activity | Q39821129 | ||
| Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations | Q40165324 | ||
| Functional modulation of parkin through physical interaction with SUMO-1. | Q40235074 | ||
| Cellular parkin mutants are soluble under non-stress conditions | Q40256265 | ||
| Induction of apoptosis in catecholaminergic PC12 cells by L-DOPA. Implications for the treatment of Parkinson's disease | Q40343900 | ||
| Pathogenic mutations inactivate parkin by distinct mechanisms. | Q40479590 | ||
| Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis | Q40545020 | ||
| Parkin attenuates manganese-induced dopaminergic cell death | Q40547152 | ||
| Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones | Q40634794 | ||
| Caspase-mediated parkin cleavage in apoptotic cell death. | Q40751610 | ||
| L-dopa cytotoxicity to PC12 cells in culture is via its autoxidation. | Q41373444 | ||
| Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation. | Q42071947 | ||
| Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane | Q42235376 | ||
| Mechanism of phospho-ubiquitin-induced PARKIN activation | Q42356433 | ||
| Effects of wild-type and mutated copper/zinc superoxide dismutase on neuronal survival and L-DOPA-induced toxicity in postnatal midbrain culture | Q42548945 | ||
| Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis. | Q43215694 | ||
| Oxidative and non-oxidative mechanisms of neuronal cell death and apoptosis by L-3,4-dihydroxyphenylalanine (L-DOPA) and dopamine. | Q43263588 | ||
| Increased vulnerability of parkin knock down PC12 cells to hydrogen peroxide toxicity: the role of salsolinol and NM-salsolinol | Q44125640 | ||
| Thiolic antioxidants protect from nitric oxide-induced toxicity in fetal midbrain cultures | Q44182712 | ||
| Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons | Q44258606 | ||
| P433 | issue | 1 | |
| P304 | page(s) | 11682 | |
| P577 | publication date | 2019-08-12 | |
| P1433 | published in | Scientific Reports | Q2261792 |
| P1476 | title | Stress-induced phospho-ubiquitin formation causes parkin degradation | |
| P478 | volume | 9 |
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