Pazopanib and Fosbretabulin in recurrent ovarian cancer (PAZOFOS): A multi-centre, phase 1b and open-label, randomised phase 2 trial

scientific article published on 10 January 2020

Pazopanib and Fosbretabulin in recurrent ovarian cancer (PAZOFOS): A multi-centre, phase 1b and open-label, randomised phase 2 trial is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.YGYNO.2020.01.005
P698PubMed publication ID31932108

P50authorGordon C. JaysonQ37839060
Susana BanerjeeQ90408920
P2093author name stringSarah Taylor
Caroline Dive
Alexander R Lyon
Cong Zhou
Jonathan Tugwood
Gordon J S Rustin
Marcia Hall
Andrew R Clamp
Robert D Morgan
Cecilia Orbegoso
Jurjees Hasan
P2860cites workModes of resistance to anti-angiogenic therapyQ24608005
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)Q28131668
Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic resultsQ33149039
Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: magnetic resonance imaging evidence for altered tumor blood flowQ33150747
A phase 3 trial of bevacizumab in ovarian cancerQ34030022
The combination of circulating Ang1 and Tie2 levels predicts progression-free survival advantage in bevacizumab-treated patients with ovarian cancerQ34134697
Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrumQ34185144
Cediranib in patients with relapsed platinum-sensitive ovarian cancer (ICON6): a randomised, double-blind, placebo-controlled phase 3 trial.Q34520190
OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancerQ36822179
Systematic analysis of circulating soluble angiogenesis-associated proteins in ICON7 identifies Tie2 as a biomarker of vascular progression on bevacizumabQ37100738
Randomized Phase II Evaluation of Bevacizumab Versus Bevacizumab Plus Fosbretabulin in Recurrent Ovarian, Tubal, or Peritoneal Carcinoma: An NRG Oncology/Gynecologic Oncology Group StudyQ37130150
Definitions for response and progression in ovarian cancer clinical trials incorporating RECIST 1.1 and CA 125 agreed by the Gynecological Cancer Intergroup (GCIG).Q37832624
Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors.Q40228810
Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4.Q42203168
Assessment of pharmacodynamic vascular response in a phase I trial of combretastatin A4 phosphateQ44478859
Combretastatin A4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imagingQ44478862
Incorporation of bevacizumab in the primary treatment of ovarian cancerQ44579933
Cancer statistics, 2018.Q47191906
A dose-escalation study of combretastatin A4-phosphate in healthy dogs.Q48268319
Phase I clinical and pharmacokinetic evaluation of the vascular-disrupting agent OXi4503 in patients with advanced solid tumors.Q52620379
Phase I trial of combretastatin A4 phosphate (CA4P) in combination with bevacizumab in patients with advanced cancer.Q52625890
Analysis of serum protein levels of angiogenic factors and their soluble receptors as markers of response to cediranib in the NCIC CTG BR.24 clinical trial.Q55041853
Histopathological and functional changes in a single-dose model of combretastatin A4 disodium phosphate-induced myocardial damage in ratsQ58596237
Plasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancerQ58599860
Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: The AURELIA open-label randomized phase III trialQ87460208
Circulating biomarkers during treatment in patients with advanced biliary tract cancer receiving cediranib in the UK ABC-03 trialQ89170919
P433issue3
P921main subjectovarian cancerQ172341
phase II clinical trialQ42824440
P304page(s)545-551
P577publication date2020-01-10
P1433published inGynecologic OncologyQ5625182
P1476titlePazopanib and Fosbretabulin in recurrent ovarian cancer (PAZOFOS): A multi-centre, phase 1b and open-label, randomised phase 2 trial
P478volume156

Reverse relations

Q98164379Targeted therapies in gynecological cancers: a comprehensive review of clinical evidencecites workP2860

Search more.