MOB (Mps one Binder) Proteins in the Hippo Pathway and Cancer

scientific article published on 10 June 2019

MOB (Mps one Binder) Proteins in the Hippo Pathway and Cancer is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3390/CELLS8060569
P932PMC publication ID6627106
P698PubMed publication ID31185650

P50authorRamazan GundogduQ57418739
P2093author name stringAlexander Hergovich
P2860cites workTowards a proteome-scale map of the human protein–protein interaction networkQ21735930
Whole genome functional analysis identifies novel components required for mitotic spindle integrity in human cellsQ21999559
Molecular cloning and characterization of phocein, a protein found from the Golgi complex to dendritic spinesQ24290924
Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 proteinQ24296945
DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcriptionQ24305415
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombinationQ24306030
A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signalingQ24306275
Functional genomic screen for modulators of ciliogenesis and cilium lengthQ24306699
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactionsQ24307997
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferationQ24308682
MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosisQ24311439
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) proteinQ24311685
Molecular characterization of human homologs of yeast MOB1Q24314682
Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expressionQ24318443
Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding proteinQ24318869
The protein kinase complement of the human genomeQ24324497
Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinasesQ24324672
A directed protein interaction network for investigating intracellular signal transductionQ24337382
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.Q24522487
Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylationQ24535404
The Hippo Signaling Pathway in Development and CancerQ24603986
A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexesQ24608914
Identification and characterization of a novel human hepatocellular carcinoma-associated geneQ24643465
Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritisQ24647387
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogeneQ24647664
Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in DrosophilaQ24670738
The Roles of NDR Protein Kinases in Hippo SignallingQ26746889
Mechanisms of Hippo pathway regulationQ26771285
MST kinases in development and diseaseQ26787040
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatmentQ27025661
Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth.Q36906753
Strong parent-of-origin effects in the association of KCNQ1 variants with type 2 diabetes in American IndiansQ37031041
Uniparental disomies, homozygous deletions, amplifications, and target genes in mantle cell lymphoma revealed by integrative high-resolution whole-genome profiling.Q37143660
The Strip-Hippo Pathway Regulates Synaptic Terminal Formation by Modulating Actin Organization at the Drosophila Neuromuscular SynapsesQ37256797
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilitiesQ37279495
Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformationQ37536809
Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth FactorsQ37575478
STRIPAK complexes: structure, biological function, and involvement in human diseasesQ37590616
MOB control: reviewing a conserved family of kinase regulatorsQ37871662
Hippo signaling in Drosophila: recent advances and insightsQ37968995
The power of MEN in cytokinesis.Q37970605
Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathwaysQ38004667
The Hippo pathway and human cancer.Q38087215
SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactionsQ38124367
Pombe's thirteen - control of fission yeast cell division by the septation initiation networkQ38358809
Regulation of Protein Interactions by Mps One Binder (MOB1) PhosphorylationQ38371689
Defining a Cancer Dependency Map.Q38696195
STRIPAK complexes in cell signaling and cancerQ38733181
Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis.Q38779591
The Hippo pathway in intestinal regeneration and diseaseQ38826172
Growth Inhibition Accompanied by MOB1 Upregulation in Human Acute Lymphoid Leukemia Cells by 3-Deazaneplanocin A.Q38841632
Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network.Q38857144
YAP/TAZ at the Roots of Cancer.Q38864941
A novel immuno-competitive capture mass spectrometry strategy for protein-protein interaction profiling reveals that LATS kinases regulate HCV replication through NS5A phosphorylationQ38973617
Structural basis for autoinhibition and its relief of MOB1 in the Hippo pathwayQ39170953
Growth-inhibitory effects of MOB2 on human hepatic carcinoma cell line SMMC-7721Q39209295
The NDR/LATS protein kinases in immunology and cancer biologyQ39349234
Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic targetQ39390952
Identification of Four Novel Loci in Asthma in European American and African American PopulationsQ39407138
Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signalingQ39662954
The MST1 and hMOB1 tumor suppressors control human centrosome duplication by regulating NDR kinase phosphorylationQ39786613
NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosisQ39907926
The Hippo/STE20 homolog SIK1 interacts with MOB1 to regulate cell proliferation and cell expansion in Arabidopsis.Q40191391
MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formationQ40277281
cN-II expression predicts survival in patients receiving gemcitabine for advanced non-small cell lung cancer.Q40415849
Regulation of Mitotic Exit in Saccharomyces cerevisiae.Q40458922
Exonic SINE insertion in STK38L causes canine early retinal degeneration (erd)Q41234566
Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth controlQ41686709
Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissuesQ41868492
Fat/Dachsous Signaling Promotes Drosophila Wing Growth by Regulating the Conformational State of the NDR Kinase WartsQ41876738
Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemiaQ41911065
Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative DiseasesQ41981157
Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogeneQ42064207
The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesisQ42468036
Mob1: defining cell polarity for proper cell divisionQ42502072
DNA methylation signatures for prediction of biochemical recurrence after radical prostatectomy of clinically localized prostate cancerQ44294541
The Mitotic Exit Network: new turns on old pathwaysQ44649056
Characterization of Hippo Pathway Components by Gene InactivationQ45423657
The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenanceQ46327230
The exocyst is required for photoreceptor ciliogenesis and retinal developmentQ46333005
The prognostic value of cN-II and cN-III enzymes in adult acute myeloid leukemiaQ46837570
Function of Drosophila mob2 in photoreceptor morphogenesisQ47071870
Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase ComplexQ47100686
SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.Q47135905
STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell linesQ47151535
TRIP6 inhibits Hippo signaling in response to tension at adherens junctions.Q47267301
Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhoodQ47813986
Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEADs-dependent repression of SOX9.Q50420631
Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancerQ27307731
NCP1/AtMOB1A Plays Key Roles in Auxin-Mediated Arabidopsis DevelopmentQ27309044
Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathwaysQ27641991
Activation of the Yeast Hippo Pathway by Phosphorylation-Dependent Assembly of Signaling ComplexesQ27677324
Seed Sequence-Matched Controls Reveal Limitations of Small Interfering RNA Knockdown in Functional and Structural Studies of Hepatitis C Virus NS5A-MOBKL1B InteractionQ27684710
Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complexQ27937216
PhosphoSitePlus, 2014: mutations, PTMs and recalibrationsQ28254001
Human LATS1 is a mitotic exit network kinaseQ28265112
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and CancerQ28269498
The cohesin complex and its roles in chromosome biologyQ28302885
Methylation Landscape of Human Breast Cancer Cells in Response to Dietary Compound ResveratrolQ28552237
Expression and distribution of phocein and members of the striatin family in neurones of rat peripheral gangliaQ28572707
NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15Q28584138
The Ste20 group kinases as regulators of MAP kinase cascadesQ29619312
Identification of Mob2, a novel regulator of larval neuromuscular junction morphology, in natural populations of Drosophila melanogasterQ30409764
Drosophila Mob family proteins interact with the related tricornered (Trc) and warts (Wts) kinasesQ30437206
Mob4 plays a role in spindle focusing in Drosophila S2 cellsQ30493988
ABL1 regulates spindle orientation in adherent cells and mammalian skin.Q30512982
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant miceQ30530942
Inference of Candidate Germline Mutator Loci in Humans from Genome-Wide Haplotype DataQ31155069
A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stabilityQ33489221
CK1epsilon is required for breast cancers dependent on beta-catenin activityQ33620584
Mutual dependence of Mob1 and the chromosomal passenger complex for localization during mitosisQ33623789
Constitutively active NDR1-PIF kinase functions independent of MST1 and hMOB1 signallingQ33725448
MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo PathwayQ33771033
DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organizationQ33821705
Hepatocarcinogenesis associated with hepatitis B, delta and C virusesQ33899640
hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.Q33916556
KRAS and YAP1 converge to regulate EMT and tumor survivalQ33946244
Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3.Q34045261
Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profilingQ34074921
Men and sin: what's the difference?Q34102523
Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases.Q34119685
Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.Q34141398
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synucleinQ34207247
Misshapen-like kinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesisQ34292029
A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretionQ34317315
Control of cell proliferation and apoptosis by mob as tumor suppressor, matsQ34402685
NDR kinases regulate essential cell processes from yeast to humansQ34512601
Clinical significance of the loss of MATS1 mRNA expression in colorectal cancer.Q34646200
Filling out the Hippo pathwayQ34648282
Regulation of DNA damage responses and cell cycle progression by hMOB2.Q34771336
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancerQ35134003
NPHP4, a cilia-associated protein, negatively regulates the Hippo pathwayQ35196050
NDR functions as a physiological YAP1 kinase in the intestinal epitheliumQ35591698
The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking MechanismQ35597254
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependenciesQ35609041
Regulation of NDR1 activity by PLK1 ensures proper spindle orientation in mitosisQ35701372
Lower Levels of Human MOB3B Are Associated with Prostate Cancer Susceptibility and Aggressive Clinicopathological CharacteristicsQ35778611
A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage responseQ35791205
Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signalingQ35879056
The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes.Q35894211
KinasePhos 2.0: a web server for identifying protein kinase-specific phosphorylation sites based on sequences and coupling patternsQ35914240
Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP DysregulationQ35954123
Photoreceptor proliferation and dysregulation of cell cycle genes in early onset inherited retinal degenerationsQ35954761
The RAM network in pathogenic fungi.Q36017845
The Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy.Q36139030
Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.Q36459320
Arl13b and the exocyst interact synergistically in ciliogenesisQ36463347
Toll Receptor-Mediated Hippo Signaling Controls Innate Immunity in Drosophila.Q36521487
Upregulation of miR-181c contributes to chemoresistance in pancreatic cancer by inactivating the Hippo signaling pathwayQ36689006
The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor networkQ36743530
Hippo signaling in organ size controlQ36793377
MOB1, an essential yeast gene required for completion of mitosis and maintenance of ploidyQ36848040
Warts Opens Up for Activation.Q50542761
Hippo Signaling in Mitosis: An Updated View in Light of the MEN Pathway.Q51337129
Mob2 Insufficiency Disrupts Neuronal Migration in the Developing Cortex.Q51733167
Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis.Q52348575
LncRNA UCA1 promotes migration and invasion in pancreatic cancer cells via the Hippo pathway.Q52671660
The characterisation of LATS2 kinase regulation in Hippo-YAP signalling.Q53242026
Monopolar spindle-one-binder protein 2 regulates the activity of large tumor suppressor/yes-associated protein to inhibit the motility of SMMC-7721 hepatocellular carcinoma cells.Q54120646
The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility.Q54241941
Mps one binder 2 gene upregulation in the stellation of astrocytes induced by cAMP-dependent pathway.Q54311176
Altered Hippo signalling in polycystic kidney disease.Q54607031
A RhoA-YAP-c-Myc signaling axis promotes the development of polycystic kidney disease.Q54976505
Machine learning identifies a core gene set predictive of acquired resistance to EGFR tyrosine kinase inhibitor.Q54978148
Striatin-1 is a B subunit of protein phosphatase PP2A that regulates dendritic arborization and spine development in striatal neurons.Q54978184
Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation SegmentQ57170505
Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein InteractionQ57192155
Human Mob1 proteins are required for cytokinesis by controlling microtubule stabilityQ57277502
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility lociQ57305944
Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signalingQ57801742
UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sitesQ57979502
Ndr kinases regulate retinal interneuron proliferation and homeostasisQ58722399
PTEN lipid phosphatase inactivation links the hippo and PI3K/Akt pathways to induce gastric tumorigenesisQ58724002
Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signalingQ60915991
Insight into the Contribution and Disruption of Host Processes during HDV ReplicationQ61811415
A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAKQ64115988
The Hippo Signaling Network and Its Biological Functions.Q64980155
Human MOB1 expression in non-small-cell lung cancerQ79802513
Clinical significance of high-Km 5'-nucleotidase (cN-II) mRNA expression in high-risk myelodysplastic syndromeQ79917002
The human tumour suppressor LATS1 is activated by human MOB1 at the membraneQ83287887
Polycystic kidney disease: a Hippo connectionQ89157599
Hippo-YAP/TAZ signalling in organ regeneration and regenerative medicineQ90463701
MST1/2 Kinase Assays Using Recombinant ProteinsQ90627410
PTEN-GSK3β-MOB1 axis controls neurite outgrowth in vitro and in vivoQ90703886
The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancerQ90721483
Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiencyQ91034906
The Legionella Effector Kinase LegK7 Hijacks the Host Hippo Pathway to Promote InfectionQ91429057
Angiomotins stimulate LATS kinase autophosphorylation and act as scaffolds that promote Hippo signalingQ91859387
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screensQ93012784
A Hippo-like Signaling Pathway Controls Tracheal Morphogenesis in Drosophila melanogasterQ93246794
The Possible Crosstalk of MOB2 With NDR1/2 Kinases in Cell Cycle and DNA Damage SignalingQ94322163
Polycystic kidney diseaseQ94519328
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue6
P921main subjectsignal transductionQ828130
neoplasmQ1216998
P577publication date2019-06-10
P1433published inCellsQ27724621
P1476titleMOB (Mps one Binder) Proteins in the Hippo Pathway and Cancer
P478volume8