Engineered AXL-ECD-Fc variants that abolish the AXL/Gas6 interaction suppress tumor cell migration

scientific article published on 15 April 2019

Engineered AXL-ECD-Fc variants that abolish the AXL/Gas6 interaction suppress tumor cell migration is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3892/OL.2019.10255
P932PMC publication ID6507473
P698PubMed publication ID31186805

P2093author name stringHao Liu
Jing Wang
Bo Hu
Yanting Duan
Beifen Shen
Jiannan Feng
Chunxia Qiao
Ming Lv
Tingting Zhou
Xinying Li
Longlong Luo
P2860cites workAXL Inhibitors in Cancer: A Medicinal Chemistry PerspectiveQ38629669
Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinomaQ38835745
ABL regulation by AXL promotes cisplatin resistance in esophageal cancerQ39250660
An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapiesQ39684120
Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesisQ39820482
Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor.Q40479676
R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancerQ43166849
Clinical significance of AXL kinase family in gastric cancerQ44095319
Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemiaQ46576090
Axl and prostasin are biomarkers for prognosis of ovarian adenocarcinomaQ46756754
Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors.Q48243258
The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer.Q54298179
First Axl inhibitor enters clinical trialsQ85717127
Structural basis for Gas6-Axl signalling.Q24299209
Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6Q24313270
Cell signaling by receptor tyrosine kinasesQ24598357
LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft modelsQ27675641
Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinasesQ28298018
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.Q33357894
Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survivalQ33667156
A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitorsQ34132936
Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.Q34217927
Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivitiesQ34390266
An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axisQ34439798
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanomaQ35596369
Kinetic exclusion assay technology: characterization of molecular interactionsQ36021387
Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancerQ36128435
Targeting Axl with an high-affinity inhibitory aptamer.Q36460465
The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic targetQ37182283
Preclinical validation of AXL receptor as a target for antibody-based pancreatic cancer immunotherapyQ37321961
Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor ResistanceQ37380418
The receptor tyrosine kinase Axl in cancer: biological functions and therapeutic implications.Q38104686
P4510describes a project that usesImageJQ1659584
P433issue6
P1104number of pages9
P304page(s)5784-5792
P577publication date2019-04-15
P1433published inOncology LettersQ20640514
P1476titleEngineered AXL-ECD-Fc variants that abolish the AXL/Gas6 interaction suppress tumor cell migration
P478volume17

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Q99579024Pharmaceutical inhibition of AXL suppresses tumor growth and invasion of esophageal squamous cell carcinomacites workP2860

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