Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination

scientific article published on 16 January 2020

Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.7554/ELIFE.52056
P932PMC publication ID6984811
P698PubMed publication ID31944179

P50authorNa WangQ92683061
Ying ShenQ90391118
P2093author name stringLiang Zhou
Zhi-Ying Wu
Ya-Jun Xie
Mengsheng Qiu
Ben-Yan Luo
Si-Min Xu
Chong-Yu Shao
Yue Hai Ke
P2860cites workPhosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelinationQ24657511
A novel role for Gab2 in bFGF-mediated cell survival during retinoic acid-induced neuronal differentiationQ24679348
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase BQ27860731
The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptorsQ28190019
Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNSQ28274507
Netrin-1 is required for the normal development of spinal cord oligodendrocytesQ28506848
Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10Q28511593
SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein functionQ28511904
Upregulation of glutamate transporter GLT-1 by mTOR-Akt-NF-кB cascade in astrocytic oxygen-glucose deprivationQ28576235
LINGO-1 negatively regulates myelination by oligodendrocytesQ28588853
Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNSQ28589814
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase BalphaQ28616168
Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathwayQ28640887
Regulation of Oligodendrocyte Differentiation and MyelinationQ29542652
beta-catenin is a target for the ubiquitin-proteasome pathwayQ29547589
Negative regulation of central nervous system myelination by polysialylated-neural cell adhesion moleculeQ30454391
Control of oligodendrocyte generation and proliferation by Shp2 protein tyrosine phosphataseQ33637565
PDGF receptors in the rat CNS: during late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage.Q33971870
bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.Q34377321
The gift of Gab.Q34593973
Rheb1 is required for mTORC1 and myelination in postnatal brain developmentQ34665970
Regulation of oligodendrocyte development in the vertebrate CNS.Q34973857
The "Gab" in signal transduction.Q35082143
Glial specification in the vertebrate neural tubeQ35752440
Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiationQ36324505
Initiation of oligodendrocyte progenitor cell migration by a PDGF-A activated extracellular regulated kinase (ERK) signaling pathwayQ37184064
Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS.Q37507612
Myelin basic protein demonstrated immunocytochemically in oligodendroglia prior to myelin sheath formationQ37587263
The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalonQ37617410
GSK-3 is a master regulator of neural progenitor homeostasisQ37670059
GSK3 signalling in neural developmentQ37774552
Oligodendrocytes: Myelination and Axonal SupportQ38534982
EGF augments TGFβ-induced epithelial-mesenchymal transition by promoting SHP2 binding to GAB1.Q38836180
Signaling by FGF Receptor 2, Not FGF Receptor 1, Regulates Myelin Thickness through Activation of ERK1/2-MAPK, Which Promotes mTORC1 Activity in an Akt-Independent MannerQ38963348
Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in miceQ40143861
Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma.Q40464595
Directional guidance of oligodendroglial migration by class 3 semaphorins and netrin-1.Q40717787
Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylationQ40872093
The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation.Q42591243
High cholesterol level is essential for myelin membrane growthQ46406733
Protein Interacting with C-Kinase 1 Deficiency Impairs Glutathione Synthesis and Increases Oxidative Stress via Reduction of Surface Excitatory Amino Acid Carrier 1.Q46738618
The effect of CXCL1 on human fetal oligodendrocyte progenitor cellsQ46971347
The protein tyrosine phosphatase Shp2 regulates oligodendrocyte differentiation and early myelination and contributes to timely remyelination.Q47317704
Notch receptor activation inhibits oligodendrocyte differentiationQ47713081
Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice.Q48314738
Epithelial disruption of Gab1 perturbs surfactant homeostasis and predisposes mice to lung injuries.Q51356121
Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord.Q51999368
Celecoxib Ameliorates Seizure Susceptibility in Autosomal Dominant Lateral Temporal Epilepsy.Q52680866
pERK1/2 Peripheral Recruitment and Filopodia Protrusion Augment Oligodendrocyte Progenitor Cell Migration: Combined Effects of PDGF-A and Fibronectin.Q52879772
Grb2-associated binder-1 is required for neuregulin-1-induced peripheral nerve myelination.Q53278576
Differential effects of growth factors on oligodendrocyte progenitor migration.Q54587196
Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation.Q54633263
Gab1 mediates neurite outgrowth, DNA synthesis, and survival in PC12 cellsQ57042566
GSK3β negatively regulates oligodendrocyte differentiation and myelination in vivoQ58456357
Multiple extracellular signals are required for long-term oligodendrocyte survivalQ72930271
Distinct roles for PI3K in proliferation and survival of oligodendrocyte progenitor cellsQ73131749
Control of progenitor cell number by mitogen supply and demandQ73617614
Dual origin of spinal oligodendrocyte progenitors and evidence for the cooperative role of Olig2 and Nkx2.2 in the control of oligodendrocyte differentiationQ77602119
GSK3β promotes the differentiation of oligodendrocyte precursor cells via β-catenin-mediated transcriptional regulationQ87584187
Leucine-Rich Glioma Inactivated 1 Promotes Oligodendrocyte Differentiation and Myelination via TSC-mTOR SignalingQ90400907
Molecular and Genetic Evidence for the PDGFRα-Independent Population of Oligodendrocyte Progenitor Cells in the Developing Mouse BrainQ91637706
P4510describes a project that usesImageJQ1659584
P921main subjectmyelinationQ14876135
P577publication date2020-01-16
P1433published ineLifeQ2000008
P1476titleGab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination
P478volume9

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Q100685115Sphingosine-1-Phosphate Receptor Modulators and Oligodendroglial Cells: Beyond Immunomodulationcites workP2860

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