Broadly resistant HIV-1 against CD4-binding site neutralizing antibodies

scientific article published on 13 June 2019

Broadly resistant HIV-1 against CD4-binding site neutralizing antibodies is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1007819
P932PMC publication ID6592578
P698PubMed publication ID31194843

P50authorLinqi ZhangQ91516083
Tongqing ZhouQ47503126
Xiaoxu HanQ87777269
P2093author name stringHan Wang
Hua Wang
Hong Shang
Shasha Shi
Yangyang Li
Xuanling Shi
Panpan Zhou
Zihao Li
Jiapeng Wu
Mengqi Fang
P2860cites workHIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled ReceptorQ22242268
Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 DonorsQ27643993
Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01Q27663293
Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 BindingQ27670829
Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep SequencingQ27671696
Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodiesQ27674878
Identification of Near-Pan-neutralizing Antibodies against HIV-1 by Deconvolution of Plasma Humoral ResponsesQ88582157
Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike GlycoproteinQ89568621
Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class AntibodiesQ27679353
Crystal Structure of a Soluble Cleaved HIV-1 Envelope TrimerQ27680496
Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope TrimerQ27680497
WebLogo: A Sequence Logo GeneratorQ27860646
CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1Q28646859
Antibody neutralization and escape by HIV-1Q29547345
Mechanisms of viral membrane fusion and its inhibitionQ29616090
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brainQ29618472
Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodiesQ29619015
Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infectionQ29619510
Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1Q29619511
HIV/AIDS epidemiology, pathogenesis, prevention, and treatmentQ30356074
Tiered categorization of a diverse panel of HIV-1 Env pseudoviruses for assessment of neutralizing antibodiesQ33614365
Genetic signatures in the envelope glycoproteins of HIV-1 that associate with broadly neutralizing antibodiesQ33719511
Early antibody therapy can induce long-lasting immunity to SHIVQ33762877
Loss of Asparagine-Linked Glycosylation Sites in Variable Region 5 of Human Immunodeficiency Virus Type 1 Envelope Is Associated with Resistance to CD4 Antibody IbalizumabQ33810849
Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activityQ34204325
Global panel of HIV-1 Env reference strains for standardized assessments of vaccine-elicited neutralizing antibodiesQ34392963
CD4-induced activation in a soluble HIV-1 Env trimerQ34510675
HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1.Q34527469
Engineered Bispecific Antibodies with Exquisite HIV-1-Neutralizing ActivityQ34531219
HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruptionQ34531858
The survival benefits of AIDS treatment in the United StatesQ34533291
Genetic and Neutralization Sensitivity of Diverse HIV-1 env Clones from Chronically Infected Patients in ChinaQ34800408
Conformational dynamics of single HIV-1 envelope trimers on the surface of native virionsQ35006601
Structure and immune recognition of trimeric pre-fusion HIV-1 Env.Q35142291
Mechanism of Neutralization by the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01Q35192782
Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestorsQ35382871
HIV-1 fitness cost associated with escape from the VRC01 class of CD4 binding site neutralizing antibodiesQ35640998
HIV-1 dynamics in vivo: implications for therapyQ35701633
Enhanced HIV-1 neutralization by antibody heteroligationQ35735385
CATNAP: a tool to compile, analyze and tally neutralizing antibody panelsQ35810109
Selection Pressure on HIV-1 Envelope by Broadly Neutralizing Antibodies to the Conserved CD4-Binding SiteQ35943521
Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality.Q36298503
Broadly Neutralizing Antibodies Developed by an HIV-Positive Elite Neutralizer Exact a Replication Fitness Cost on the Contemporaneous VirusQ36397394
A Single Residue within the V5 Region of HIV-1 Envelope Facilitates Viral Escape from the Broadly Neutralizing Monoclonal Antibody VRC01Q36466846
Towards HIV-1 remission: potential roles for broadly neutralizing antibodiesQ36515149
Selection for specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary infectionQ36647820
Bispecific Anti-HIV-1 Antibodies with Enhanced Breadth and PotencyQ37145901
HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized miceQ37236504
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice.Q37259407
Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigmQ37348882
Effect of HIV Antibody VRC01 on Viral Rebound after Treatment InterruptionQ37624842
Of Mice, Macaques, and Men: Broadly Neutralizing Antibody Immunotherapy for HIV-1.Q38643834
Determinants of HIV-1 CD4-independent brain adaptation.Q38719228
Persistence of VRC01-resistant HIV-1 during antiretroviral therapyQ39036775
Antibody-virus co-evolution in HIV infection: paths for HIV vaccine developmentQ39108751
Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infectionQ40173380
Virological Control by the CD4-Binding Site Antibody N6 in Simian-Human Immunodeficiency Virus-Infected Rhesus MonkeysQ40187584
Quantification of the Impact of the HIV-1-Glycan Shield on Antibody ElicitationQ40226810
Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.Q40449526
Corrigendum: Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.Q40743748
HIV: Potency needs constancyQ41690058
Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail.Q41933482
Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaquesQ41933491
Anti-CD4 Monoclonal Antibody Ibalizumab Exhibits Breadth and Potency Against HIV-1, With Natural Resistance Mediated by the Loss of a V5 Glycan in EnvelopeQ45901244
Fc receptor but not complement binding is important in antibody protection against HIV.Q46545827
Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice.Q52692811
Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activityQ53081267
HIV-1 Vaccines Based on Antibody Identification, B Cell Ontogeny, and Epitope StructureQ54210145
Diverse pathways of escape from all well-characterized VRC01-class broadly neutralizing HIV-1 antibodiesQ57003103
Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeysQ57039969
Recent progress in broadly neutralizing antibodies to HIVQ58569712
Tracing HIV-1 strains that imprint broadly neutralizing antibody responsesQ59054303
Combination therapy with anti-HIV-1 antibodies maintains viral suppressionQ59090059
Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individualsQ59351843
CD4 occupancy triggers sequential pre-fusion conformational states of the HIV-1 envelope trimer with relevance for broadly neutralizing antibody activityQ61815651
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue6
P304page(s)e1007819
P577publication date2019-06-13
P1433published inPLOS PathogensQ283209
P1476titleBroadly resistant HIV-1 against CD4-binding site neutralizing antibodies
P478volume15

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