Mitochondrial NCKX5 regulates melanosomal biogenesis and pigment production

scientific article published on 15 July 2019

Mitochondrial NCKX5 regulates melanosomal biogenesis and pigment production is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1242/JCS.232009
P932PMC publication ID6679581
P698PubMed publication ID31201282

P50authorWei LiQ88515477
Zhao ZhangQ92760919
Juanjuan GongQ92760924
Aihua WeiQ92760927
P2093author name stringElena V Sviderskaya
P2860cites workNCLX is an essential component of mitochondrial Na+/Ca2+ exchangeQ22254831
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MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomesQ24294239
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The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesisQ24338990
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Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signalingQ28277133
SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humansQ28287208
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Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responsesQ29616076
The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viabilityQ30274561
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Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial primingQ34107322
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Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymesQ36119125
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Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesisQ36323476
The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes.Q37008566
Hermansky-Pudlak syndrome: pigmentary and non-pigmentary defects and their pathogenesisQ38061490
Functional and structural properties of the NCKX2 Na(+)-Ca (2+)/K (+) exchanger: a comparison with the NCX1 Na (+)/Ca (2+) exchangerQ38066041
The SLC24 gene family of Na⁺/Ca²⁺-K⁺ exchangers: from sight and smell to memory consolidation and skin pigmentationQ38090784
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Calcium signaling at ER membrane contact sitesQ38348273
PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic NeuronsQ38829987
The repeat domain of the melanosomal matrix protein PMEL17/GP100 is required for the formation of organellar fibersQ40282474
Clathrin-dependent and -independent internalization of plasma membrane sphingolipids initiates two Golgi targeting pathwaysQ41981023
Force- and Ca²⁺-dependent internalization of integrins in cultured endothelial cellsQ42497701
A line of non-tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growthQ42820599
Monitoring mitochondrial [Ca(2+)] dynamics with rhod-2, ratiometric pericam and aequorinQ42953502
Mitochondrial impairment in peripheral blood mononuclear cells during the active phase of vitiligoQ43776992
Melanin has a role in Ca2+ homeostasis in human melanocytes.Q44352751
SLC24A5 mutations are associated with non-syndromic oculocutaneous albinismQ45345288
Exome sequencing identifies SLC24A5 as a candidate gene for nonsyndromic oculocutaneous albinismQ45841491
Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophoresQ46089769
Mutations in AP3D1 associated with immunodeficiency and seizures define a new type of Hermansky-Pudlak syndromeQ48266772
VitiligoQ55980470
Mitochondria and Melanosomes Establish Physical Contacts Modulated by Mfn2 and Involved in Organelle BiogenesisQ61409083
Human hair melanins: what we have learned and have not learned from mouse coat color pigmentationQ62661027
Selectivity of Inhibition of Na+-Ca2+ Exchange of Heart Mitochondria by Benzothiazepine CGP-37157Q72075722
Quantification of Ca(2+) binding to melanin supports the hypothesis that melanosomes serve a functional role in regulating calcium homeostasisQ79982861
Regulation of calcium signaling in dendritic cells by 1,25-dihydroxyvitamin D3Q82745390
Cellular localization of the K+ -dependent Na+ -Ca2+ exchanger NCKX5 and the role of the cytoplasmic loop in its distribution in pigmented cellsQ89452101
P433issue14
P577publication date2019-07-15
P1433published inJournal of Cell ScienceQ1524177
P1476titleMitochondrial NCKX5 regulates melanosomal biogenesis and pigment production
P478volume132