RhoA-ROCK Signaling as a Therapeutic Target in Traumatic Brain Injury

scientific article published on 18 January 2020

RhoA-ROCK Signaling as a Therapeutic Target in Traumatic Brain Injury is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/CELLS9010245
P932PMC publication ID7016605
P698PubMed publication ID31963704

P50authorShalaka MulherkarQ90062424
P2093author name stringKimberley F Tolias
P2860cites workSignaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinaseQ22010473
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LIM Kinase, a Newly Identified Regulator of Presynaptic Remodeling by Rod Photoreceptors After InjuryQ36380246
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Versican V2 and the central inhibitory domain of Nogo-A inhibit neurite growth via p75NTR/NgR-independent pathways that converge at RhoA.Q51822782
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AMA0076, a novel, locally acting Rho kinase inhibitor, potently lowers intraocular pressure in New Zealand white rabbits with minimal hyperemia.Q54381360
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Lesional expression of RhoA and RhoB following traumatic brain injury in humansQ80340778
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Transcriptomic profiling of astrocytes treated with the Rho kinase inhibitor fasudil reveals cytoskeletal and pro-survival responsesQ38502206
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RhoA-ROCK Inhibition Reverses Synaptic Remodeling and Motor and Cognitive Deficits Caused by Traumatic Brain Injury.Q41636767
Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons.Q41745546
Left-right locomotor circuitry depends on RhoA-driven organization of the neuroepithelium in the developing spinal cordQ41768091
Selective death of newborn neurons in hippocampal dentate gyrus following moderate experimental traumatic brain injuryQ41864061
The small GTPase RhoA is required to maintain spinal cord neuroepithelium organization and the neural stem cell pool.Q42486077
Moderate traumatic brain injury triggers rapid necrotic death of immature neurons in the hippocampusQ42571551
EphB3 signaling propagates synaptic dysfunction in the traumatic injured brainQ42597759
A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranesQ42819347
Fasudil protects hippocampal neurons against hypoxia‐reoxygenation injury by suppressing microglial inflammatory responses in miceQ42873128
Fasudil, a Rho kinase inhibitor, drives mobilization of adult neural stem cells after hypoxia/reoxygenation injury in miceQ43242334
The Rho-kinase (ROCK) inhibitor Y-27632 protects against excitotoxicity-induced neuronal death in vivo and in vitroQ43843434
Traumatic brain injury induced cell proliferation in the adult mammalian central nervous systemQ44091907
Psychiatric disorders following traumatic brain injury: their nature and frequencyQ44412513
Understanding sequelae of injury mechanisms and mild traumatic brain injury incurred during the conflicts in Iraq and Afghanistan: persistent postconcussive symptoms and posttraumatic stress disorderQ44478354
Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retinaQ44985191
RhoA, RhoB, RhoC, Rac1, Cdc42, and Tc10 mRNA levels in spinal cord, sensory ganglia, and corticospinal tract neurons and long-lasting specific changes following spinal cord injuryQ45286570
Rho kinase inhibitor Fasudil induces neuroprotection and neurogenesis partially through astrocyte-derived G-CSF.Q46009054
Efficacy of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retinaQ46403633
Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trialQ46591653
Role of Rho GTPase in astrocyte morphology and migratory response during in vitro wound healing.Q46692802
Activation of Rho after traumatic brain injury and seizure in ratsQ46920789
Widespread cellular proliferation and focal neurogenesis after traumatic brain injury in the rat.Q48181722
Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhageQ48414234
Rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the Akt activation and PTEN inactivation in the ischemic penumbra of rat brainQ48535363
Efficacy and safety of fasudil in patients with subarachnoid hemorrhage: final results of a randomized trial of fasudil versus nimodipineQ48821423
Rho kinase inhibition following traumatic brain injury in mice promotes functional improvement and acute neuron survival but has little effect on neurogenesis, glial responses or neuroinflammationQ48891777
Impact of the clinical use of ROCK inhibitor on the pathogenesis and treatment of glaucomaQ49992681
Rho Inhibitor VX-210 in Acute Traumatic Subaxial Cervical Spinal Cord Injury: Design of the SPinal Cord Injury Rho INhibition InvestiGation (SPRING) Clinical TrialQ50115568
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P577publication date2020-01-18
P1433published inCellsQ27724621
P1476titleRhoA-ROCK Signaling as a Therapeutic Target in Traumatic Brain Injury
P478volume9

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