Mini Review: New Treatments in Psoriatic Arthritis. Focus on the IL-23/17 Axis

scientific article published on 06 August 2019

Mini Review: New Treatments in Psoriatic Arthritis. Focus on the IL-23/17 Axis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FPHAR.2019.00872
P932PMC publication ID6691125
P698PubMed publication ID31447673

P50authorDimitrios P. BogdanosQ48362185
P2093author name stringEfterpi Zafiriou
Lazaros I Sakkas
P2860cites workCutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesisQ28208761
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Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E.Q49335379
Efficacy and safety of biologics targeting interleukin-6, -12/23 and -17 pathways for peripheral psoriatic arthritis: a network meta-analysisQ49824739
Augmented Th17 Differentiation Leads to Cutaneous and Synovio-Entheseal Inflammation in a Novel Model of Psoriatic Arthritis.Q50034719
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Dual neutralization of both IL-17A and IL-17F with bimekizumab in patients with psoriasis: results from BE ABLE 1, a 12-week randomized, double-blinded placebo-controlled phase 2b trial.Q51730950
Secukinumab improves active psoriatic arthritis symptoms and inhibits radiographic progression: primary results from the randomised, double-blind, phase III FUTURE 5 study.Q52650418
Prevalence of rheumatologist-diagnosed psoriatic arthritis in patients with psoriasis in European/North American dermatology clinics.Q53125208
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Tildrakizumab for the treatment of psoriasisQ58614044
Ixekizumab is efficacious when used alone or when added to conventional synthetic disease-modifying antirheumatic drugs (cDMARDs) in patients with active psoriatic arthritis and previous inadequate response or intolerance to tumour necrosis factor inQ58759049
Brodalumab, an Anti–Interleukin-17–Receptor Antibody for PsoriasisQ58992083
Cost-effectiveness analysis of secukinumab versus other biologics and apremilast in the treatment of active Psoriatic arthritis: a Finnish perspectiveQ59337044
Secukinumab provides sustained PASDAS-defined remission in psoriatic arthritis and improves health-related quality of life in patients achieving remission: 2-year results from the phase III FUTURE 2 studyQ59790112
Ixekizumab and complete resolution of enthesitis and dactylitis: integrated analysis of two phase 3 randomized trials in psoriatic arthritisQ61806742
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A phase 1, double-blind, placebo-controlled study evaluating single subcutaneous administrations of a human interleukin-12/23 monoclonal antibody in subjects with plaque psoriasisQ61853646
Population Pharmacokinetics of the Interleukin-23 Inhibitor Risankizumab in Subjects with Psoriasis and Crohn's Disease: Analyses of Phase I and II TrialsQ62633603
Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate to severe plaque psoriasis: CLEAR, a randomized controlled trialQ85410950
Efficacy and safety of guselkumab in patients with active psoriatic arthritis: a randomised, double-blind, placebo-controlled, phase 2 studyQ89074034
Safety of Ixekizumab in Patients With Psoriatic Arthritis: Results From a Pooled Analysis of Three Clinical TrialsQ91198175
Ustekinumab Safety in Psoriasis, Psoriatic Arthritis, and Crohn's Disease: An Integrated Analysis of Phase II/III Clinical Development ProgramsQ91438247
Matching-adjusted indirect comparison: secukinumab versus infliximab in biologic-naive patients with psoriatic arthritisQ91923632
Treatment of Dactylitis and Enthesitis in Psoriatic Arthritis with Biologic Agents: A Systematic Review and MetaanalysisQ92061008
Secukinumab produces a quick increase in WNT signalling antagonists in patients with psoriatic arthritisQ93000179
Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)Q28280465
Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skinQ28301222
IL-17B and IL-17C are associated with TNF-alpha production and contribute to the exacerbation of inflammatory arthritisQ28587556
Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammationQ29614224
Ustekinumab, an anti-IL-12/23 p40 monoclonal antibody, inhibits radiographic progression in patients with active psoriatic arthritis: results of an integrated analysis of radiographic data from the phase 3, multicentre, randomised, double-blind, plaQ30760660
Are psoriasis and psoriatic arthritis the same disease? The IL-23/IL-17 axis data.Q31133026
First-in-human randomized study of bimekizumab, a humanized monoclonal antibody and selective dual inhibitor of IL-17A and IL-17F, in mild psoriasisQ33593625
Efficacy and safety of the anti-IL-12/23 p40 monoclonal antibody, ustekinumab, in patients with active psoriatic arthritis despite conventional non-biological and biological anti-tumour necrosis factor therapy: 6-month and 1-year results of the phasQ33659249
Mannan induces ROS-regulated, IL-17A-dependent psoriasis arthritis-like disease in miceQ34144256
Ixekizumab, an interleukin-17A specific monoclonal antibody, for the treatment of biologic-naive patients with active psoriatic arthritis: results from the 24-week randomised, double-blind, placebo-controlled and active (adalimumab)-controlled perioQ34538249
Heterogeneous expression pattern of interleukin 17A (IL-17A), IL-17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti-IL-17 therapy?Q34937925
Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivoQ35091158
Regulation of inflammatory responses by IL-17FQ36639980
The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responsesQ37040371
Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1aQ37346670
Th17 and Th22 cells in psoriatic arthritis and psoriasisQ37689670
Signaling of interleukin-17 family cytokines in immunity and inflammationQ37815900
IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases.Q38539817
Efficacy and safety of guselkumab, an anti-interleukin-23 monoclonal antibody, compared with adalimumab for the continuous treatment of patients with moderate to severe psoriasis: Results from the phase III, double-blinded, placebo- and active compaQ38558538
Secukinumab Inhibition of Interleukin-17A in Patients with Psoriatic ArthritisQ38958215
Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blind, placebo-controlled, phase 3 trialQ38989105
Brodalumab, an anti-IL17RA monoclonal antibody, in psoriatic arthritisQ39238937
Interleukin 17 is a chief orchestrator of immunityQ39314776
The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complexQ39953231
Ixekizumab for the treatment of patients with active psoriatic arthritis and an inadequate response to tumour necrosis factor inhibitors: results from the 24-week randomised, double-blind, placebo-controlled period of the SPIRIT-P2 phase 3 trialQ40196632
A randomized phase 2b trial of baricitinib, an oral Janus kinase (JAK) 1/JAK2 inhibitor, in patients with moderate-to-severe psoriasis.Q40821601
Phase 3 Studies Comparing Brodalumab with Ustekinumab in PsoriasisQ40973506
The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasisQ41620801
IL-17 and TNF synergistically modulate cytokine expression while suppressing melanogenesis: potential relevance to psoriasisQ41975379
Risankizumab versus Ustekinumab for Moderate-to-Severe Plaque PsoriasisQ42508679
Safety and efficacy of ABT-874, a fully human interleukin 12/23 monoclonal antibody, in the treatment of moderate to severe chronic plaque psoriasis: results of a randomized, placebo-controlled, phase 2 trialQ44525441
IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cellsQ46043893
Psoriasis prevalence among adults in the United StatesQ46308366
Ixekizumab efficacy and safety with and without concomitant conventional disease-modifying antirheumatic drugs (cDMARDs) in biologic DMARD (bDMARD)-naïve patients with active psoriatic arthritis (PsA): results from SPIRIT-P1.Q47148249
Comparative effectiveness of abatacept, apremilast, secukinumab and ustekinumab treatment of psoriatic arthritis: a systematic review and network meta-analysis.Q47236145
Dual IL-17A and IL-17F neutralisation by bimekizumab in psoriatic arthritis: evidence from preclinical experiments and a randomised placebo-controlled clinical trial that IL-17F contributes to human chronic tissue inflammationQ47253021
Tofacitinib or Adalimumab versus Placebo for Psoriatic ArthritisQ47633796
Tofacitinib for Psoriatic Arthritis in Patients with an Inadequate Response to TNF InhibitorsQ47633814
Efficacy and safety of ixekizumab for the treatment of moderate-to-severe plaque psoriasis: Results through 108 weeks of a randomized, controlled phase 3 clinical trial (UNCOVER-3).Q47792431
Psoriasis pathogenesis and the development of novel targeted immune therapies.Q47830025
First-in-human study to assess guselkumab (anti-IL-23 mAb) pharmacokinetics/safety in healthy subjects and patients with moderate-to-severe psoriasis.Q48115736
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P304page(s)872
P577publication date2019-08-06
P1433published inFrontiers in PharmacologyQ2681208
P1476titleMini Review: New Treatments in Psoriatic Arthritis. Focus on the IL-23/17 Axis
P478volume10

Reverse relations

cites work (P2860)
Q90630892A novel treatment for psoriatic arthritis: Janus kinase inhibitors
Q97533806Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease
Q89608730Inhibition of interleukins 17A and 17F in psoriatic arthritis

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