Identification of a clinical compound losmapimod that blocks Lassa virus entry

scientific article published on 04 April 2019

Identification of a clinical compound losmapimod that blocks Lassa virus entry is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.ANTIVIRAL.2019.03.014
P932PMC publication ID7111477
P698PubMed publication ID30953674

P50authorXiangguo QiuQ66680131
P2093author name stringKe Tang
Qing Chen
Xiaoyu Zhang
Wenjun Zhu
Ying Guo
Feihu Yan
Jiamei Guo
Logan Banadyga
Shihua He
P2860cites workDissection of the role of the stable signal peptide of the arenavirus envelope glycoprotein in membrane fusionQ36023061
The broad-spectrum antiviral favipiravir protects guinea pigs from lethal Lassa virus infection post-disease onsetQ36146469
The role of proteolytic processing and the stable signal peptide in expression of the Old World arenavirus envelope glycoprotein ectodomainQ36532761
Lassa Virus Cell Entry via Dystroglycan Involves an Unusual Pathway of Macropinocytosis.Q37073355
Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary diseaseQ38323383
Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa FeverQ38565357
Mutational Analysis of Lassa Virus Glycoprotein Highlights Regions Required for Alpha-Dystroglycan UtilizationQ38662402
Early Viral Entry Assays for the Identification and Evaluation of Antiviral CompoundsQ38820461
New World Arenavirus Biology.Q39394740
Drug Repurposing: New Treatments for Zika Virus Infection?Q40054261
pH-induced activation of arenavirus membrane fusion is antagonized by small-molecule inhibitorsQ40410440
Identification of a broad-spectrum arenavirus entry inhibitorQ40411501
Determining Ribavirin's mechanism of action against Lassa virus infectionQ41718140
NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.Q45325056
Past, present, and future of arenavirus taxonomyQ46734627
Establishment of pseudovirus infection mouse models for in vivo pharmacodynamics evaluation of filovirus entry inhibitors.Q54107807
Current research for a vaccine against Lassa hemorrhagic fever virusQ56909960
Screening and Identification of Lassa Virus Entry Inhibitors from an FDA-Approved Drug LibraryQ56999457
Tangeretin, an extract from Citrus peels, blocks cellular entry of arenaviruses that cause viral hemorrhagic feverQ58550872
Lassa feverQ88504090
A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTSQ107473800
Virus entry. Lassa virus entry requires a trigger-induced receptor switchQ24299858
Genetic diversity among Lassa virus strainsQ24525321
X-ray structure of the arenavirus glycoprotein GP2 in its postfusion hairpin conformationQ27675862
Fusion of Enveloped Viruses in EndosomesQ28073406
Regulation of Muscle Stem Cell Functions: A Focus on the p38 MAPK Signaling PathwayQ28078887
Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virusQ28291275
Drug repositioning: identifying and developing new uses for existing drugsQ29614779
A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activityQ30279239
Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infectionQ30419612
Analysis of Lujo virus cell entry using pseudotype vesicular stomatitis virusQ33744103
Arenavirus stable signal peptide is the keystone subunit for glycoprotein complex organizationQ34440915
Arenaviruses. I. The epidemiology molecular and cell biology of arenaviruses. Introduction.Q34622855
A specific interaction of small molecule entry inhibitors with the envelope glycoprotein complex of the Junín hemorrhagic fever arenavirusQ34675921
Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugsQ35050840
Identification and Mechanism of Action of a Novel Small-Molecule Inhibitor of Arenavirus MultiplicationQ35751585
Cationic amphiphilic drugs cause a marked expansion of apparent lysosomal volume: implications for an intracellular distribution-based drug interactionQ35947304
Small-Molecule Fusion Inhibitors Bind the pH-Sensing Stable Signal Peptide-GP2 Subunit Interface of the Lassa Virus Envelope GlycoproteinQ36021966
P921main subjectLassa virusQ1806636
P1104number of pages10
P304page(s)68-77
P577publication date2019-04-04
P1433published inAntiviral ResearchQ4775352
P1476titleIdentification of a clinical compound losmapimod that blocks Lassa virus entry
P478volume167

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cites work (P2860)
Q89469891Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root
Q96304535Identification of the dietary supplement capsaicin as an inhibitor of Lassa virus entry
Q94954969Lassa Virus Genetics

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