SBP2 deficiency in adipose tissue macrophages drives insulin resistance in obesity

scientific article published on 14 August 2019

SBP2 deficiency in adipose tissue macrophages drives insulin resistance in obesity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1126/SCIADV.AAV0198
P932PMC publication ID6693917
P698PubMed publication ID31453320

P50authorDi WangQ61142360
Ning WangQ87781635
Yibin FengQ87781639
P2093author name stringCheng Zhang
Sha Li
Chi-Ming Che
Yu Xu
Wen Xia
Hor-Yue Tan
P2860cites workChronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistanceQ24617743
Adipose tissue macrophages: going off track during obesityQ26768692
MsrA Overexpression Targeted to the Mitochondria, but Not Cytosol, Preserves Insulin Sensitivity in Diet-Induced Obese MiceQ27314952
Secisbp2 is essential for embryonic development and enhances selenoprotein expressionQ28585049
Obesity induces a phenotypic switch in adipose tissue macrophage polarizationQ29547686
Female mice are protected against high-fat diet induced metabolic syndrome and increase the regulatory T cell population in adipose tissueQ31103663
Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expressionQ33513325
MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseasesQ33569870
Adipose tissue macrophages promote myelopoiesis and monocytosis in obesityQ33724394
Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophagesQ34316035
Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humansQ34360195
Time-course microarrays reveal early activation of the immune transcriptome and adipokine dysregulation leads to fibrosis in visceral adipose depots during diet-induced obesityQ34402691
Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition?Q34448790
Mutations in SECISBP2 result in abnormal thyroid hormone metabolismQ34460050
Subcutaneous adipose tissue macrophage infiltration is associated with hepatic and visceral fat deposition, hyperinsulinemia, and stimulation of NF-κB stress pathway.Q35404775
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?Q35486035
Expression of Selenoprotein Genes Is Affected by Obesity of Pigs Fed a High-Fat DietQ35775167
Relation of depot-specific adipose inflammation to insulin resistance in human obesity.Q35926642
Five stages of evolving beta-cell dysfunction during progression to diabetesQ35961960
Diet-induced obesity in the selenocysteine lyase knockout mouseQ36108624
Telmisartan directly ameliorates the neuronal inflammatory response to IL-1β partly through the JNK/c-Jun and NADPH oxidase pathwaysQ36136825
Local proliferation initiates macrophage accumulation in adipose tissue during obesityQ36775005
Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese miceQ36855257
ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophagesQ36973955
Clinical and molecular characterization of a novel selenocysteine insertion sequence-binding protein 2 (SBP2) gene mutation (R128X).Q37379565
Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activationQ37612556
T cell-derived IL-22 amplifies IL-1β-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes.Q39024643
CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitorsQ40089118
SECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translationQ41694012
Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammationQ41838863
Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced ObesityQ42379901
Characterization of multilayered nanoparticles encapsulated in yeast cell wall particles for DNA deliveryQ42815016
Selenoprotein-related disease in a young girl caused by nonsense mutations in the SBP2 geneQ43054577
Single cell transcriptomics suggest that human adipocyte progenitor cells constitute a homogeneous cell population.Q43535599
Rapid Elevation in CMPF May Act As a Tipping Point in Diabetes Development.Q46576600
Inflammasome activation is reactive oxygen species dependent and mediates irinotecan-induced mucositis through IL-1β and IL-18 in mice.Q46876184
Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity.Q48192209
Frontline Science: Rapid adipose tissue expansion triggers unique proliferation and lipid accumulation profiles in adipose tissue macrophages.Q53705576
Macrophage phenotype and bioenergetics are controlled by oxidized phospholipids identified in lean and obese adipose tissueQ55031285
Deficient production of IL-1 receptor antagonist and IL-6 coupled to oxidative stress in cryopyrin-associated periodic syndrome monocytesQ61050010
P433issue8
P921main subjectinsulin resistanceQ1053470
P304page(s)eaav0198
P577publication date2019-08-14
P1433published inScience AdvancesQ19881044
P1476titleSBP2 deficiency in adipose tissue macrophages drives insulin resistance in obesity
P478volume5

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