Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans

scientific article published on 26 August 2019

Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3390/JCM8091309
P932PMC publication ID6780899
P698PubMed publication ID31454946

P50authorEduardo Gomez BañuelosQ83207577
P2093author name stringFelipe Andrade
Erika Darrah
Amarshi Mukherjee
P2860cites workDiseases of the Human Body Which Have Been Traced to the Action of Mouth-BacteriaQ91487362
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Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD)Q21089593
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PPAD is not targeted as a citrullinated protein in rheumatoid arthritis, but remains a candidate for inducing autoimmunityQ43872784
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Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritisQ44616885
Identification of Porphyromonas gingivalis proteins secreted by the Por secretion systemQ44705620
Absence of citrulline-specific autoantibodies in animal models of autoimmunityQ44973891
Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritisQ45091885
Presence and role of anti-citrullinated protein antibodies in experimental arthritis modelsQ45137792
Latex slide agglutination vs. ELISA system. Rheumatoid factor detection in inflamed human gingivaQ45385228
Expression of peptidylarginine deiminase-2 and -4, citrullinated proteins and anti-citrullinated protein antibodies in human gingivaQ46357914
Ammonia impairs neutrophil phagocytic function in liver diseaseQ46433867
Occurrence of Aggregatibacter actinomycetemcomitans serotypes in subgingival plaque from United States subjectsQ46444466
Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritisQ46453983
Periodontal pathogens directly promote autoimmune experimental arthritis by inducing a TLR2- and IL-1-driven Th17 responseQ46479336
Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammationQ46925018
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Gingival tissue, an extrasynovial source of malondialdehyde-acetaldehyde adducts, citrullinated and carbamylated proteins.Q47634678
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Autoantibodies From Single Circulating Plasmablasts React With Citrullinated Antigens and Porphyromonas gingivalis in Rheumatoid Arthritis.Q48072438
Human microbiome, infections, and rheumatic diseaseQ48365860
A Lecture on Tertiary Syphilis, or Syphilitic CachexiaQ48582690
Methylation of arginine residues interferes with citrullination by peptidylarginine deiminases in vitroQ50335558
The case for periodontitis in the pathogenesis of rheumatoid arthritisQ40081890
The aggravation of arthritis by periodontitis is dependent of IL-17 receptor A activation.Q40215319
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Porphyromonas gingivalis infection exacerbates the onset of rheumatoid arthritis in SKG mice.Q40597488
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Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritisQ40697747
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Actinobacillus actinomycetemcomitans in human periodontal disease: a cross-sectional microbiological investigation.Q41181774
Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host responseQ28658053
The pathogenesis of rheumatoid arthritisQ29614957
Increased leukotoxin production: Characterization of 100 base pairs within the 530 base pair leukotoxin promoter region of Aggregatibacter actinomycetemcomitans.Q33689608
Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in nonoral infectionsQ33752041
Porphyromonas gingivalis peptidylarginine deiminase, a key contributor in the pathogenesis of experimental periodontal disease and experimental arthritisQ33800824
Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminaseQ33876323
Antigenic studies of oral and nonoral black-pigmented Bacteroides strainsQ33906633
The first description of rheumatoid arthritis. Unabridged text of the doctoral dissertation presented in 1800.Q33944361
Por secretion system-dependent secretion and glycosylation of Porphyromonas gingivalis hemin-binding protein 35.Q33952348
Relative importance of genetic effects in rheumatoid arthritis: historical cohort study of Danish nationwide twin population.Q33953270
Periodontitis and Porphyromonas gingivalis in patients with rheumatoid arthritisQ33970887
Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis?Q34027435
Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: implications for autoimmunity in rheumatoid arthritisQ34137749
Properties of peptidylarginine deiminase from the epidermis of newborn ratsQ34281846
The keystone-pathogen hypothesis.Q34297138
Twin concordance rates for rheumatoid arthritis: results from a nationwide study.Q34357436
Hand to Mouth: A Systematic Review and Meta-Analysis of the Association between Rheumatoid Arthritis and PeriodontitisQ34518022
Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis.Q34547370
On the origin of rheumatoid arthritis: the impact of environment and genes--a population based twin studyQ34611984
The immunopathogenesis of progressive chronic inflammatory periodontal diseaseQ34620244
Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regressionQ34950441
Origin and function of the cellular components in gingival crevice fluidQ35092082
Defining the role of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) in rheumatoid arthritis through the study of PPAD biologyQ35202486
Leukotoxic activity of Aggregatibacter actinomycetemcomitans and periodontal attachment lossQ35219631
Aggregatibacter actinomycetemcomitans leukotoxin: a powerful tool with capacity to cause imbalance in the host inflammatory responseQ35458854
The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatmentQ35716503
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Regulation of Actinobacillus actinomycetemcomitans leukotoxin expression: analysis of the promoter regions of leukotoxic and minimally leukotoxic strainsQ35773013
Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminaseQ35804181
Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritisQ35825742
Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case-control studyQ35832816
Identification of citrullinated peptides in the synovial fluid of patients with rheumatoid arthritis using LC-MALDI-TOF/TOF.Q35984220
Prevalence of Periodontitis in Patients with Established Rheumatoid Arthritis: A Swedish Population Based Case-Control StudyQ36023951
Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor designQ36057948
Periodontal treatment decreases levels of antibodies to Porphyromonas gingivalis and citrulline in patients with rheumatoid arthritis and periodontitis.Q50967903
Association between anti-Porphyromonas gingivalis antibody, anti-citrullinated protein antibodies, and rheumatoid arthritis : A meta-analysis.Q50972447
Extracellular Proteome and Citrullinome of the Oral Pathogen Porphyromonas gingivalis.Q51422899
Assessing the citrullinome in rheumatoid arthritis synovial fluid with and without enrichment of citrullinated peptides.Q51742230
Dysbiotic subgingival microbial communities in periodontally healthy patients with rheumatoid arthritis.Q51765178
Historical aspects of the aetiology of rheumatoid arthritis.Q52399718
Mining the human tissue proteome for protein citrullination.Q52611944
Response to comment on "Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis".Q52644028
There's no place like OM: Vesicular sorting and secretion of the peptidylarginine deiminase of Porphyromonas gingivalis.Q52674052
A "case control" study on the rôle of HLA DR4 in severe periodontitis and rapidly progressive periodontitis. Identification of types and subtypes using molecular biology (PCR.SSO).Q53348043
IgG Rheumatoid Factor in Dental Periapical Lesions of Patients with Rheumatoid DiseaseQ53802412
Comment on "Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis".Q54251451
Clinical periodontal and microbiologic parameters in patients with rheumatoid arthritis.Q54383088
Serotypes of Aggregatibacter actinomycetemcomitans in patients with different ethnic backgrounds.Q54451597
Infection due to Actinobacillus actinomycetemcomitans and Haemophilus aphrophilus.Q54705985
Dropping anchor: attachment of peptidylarginine deiminase via A-LPS to secreted outer membrane vesicles of Porphyromonas gingivalis.Q55279783
Rheumatoid arthritisQ56966841
The oral microbiota: dynamic communities and host interactionsQ57291600
Interplay between P. gingivalis, F. nucleatum and A. actinomycetemcomitans in murine alveolar bone loss, arthritis onset and progressionQ57477197
The involvement of C5a in the progression of experimental arthritis with Porphyromonas gingivalis infection in SKG miceQ58613479
Subgingival microbiome of rheumatoid arthritis patients in relation to their disease status and periodontal healthQ58720531
The Etiology of Rheumatism Considered from a Bacterial Point of ViewQ58774301
Rheumatoid Arthritis-Associated Autoimmunity Due to and Its Resolution With Antibiotic TherapyQ59136376
Experimental arthritis exacerbates Aggregatibacter actinomycetemcomitans-induced periodontitis in miceQ59387635
Infliximab Induced a Dissociated Response of Severe Periodontal Biomarkers in Rheumatoid Arthritis Patients.Q64986675
Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis.Q64994712
The occurrence of Actinobacillus actinomycetemcomitans, Bacteroides gingivalis and Bacteroides intermedius in destructive periodontal disease in adultsQ68734468
Human leukocyte antigen (HLA) DR4. Positive association with rapidly progressing periodontitisQ68829575
Periodontal conditions in adults with rheumatoid arthritisQ69748259
Cytology of synovial fluid in rheumatoid arthritisQ70137220
Symposium on infective endocarditis. III. Endocarditis due to gram-negative bacteria. Report of 56 casesQ70293445
Chronic allergic inflammation induced by repeated deposition of antigen in rabbit gingival pocketsQ70873452
Quantitative parameters of early human gingival inflammationQ71016139
Levels of serum IgG against Porphyromonas gingivalis in patients with rapidly progressive periodontitis, rheumatoid arthritis and adult periodontitisQ71565604
???Q28262177
Identification of rheumatoid factor in periodontal diseaseQ72052135
Participation of an arginyl residue of insulin chain B in the inhibition of hemagglutination by Porphyromonas gingivalisQ72351946
Focal infection revisitedQ72359415
Cytopathic effects of Actinobacillus actinomycetemcomitans on monkey blood leukocytesQ72810438
Actinobacillus Actinomycetemcomitans and Hemophilus AphrophilusQ76485688
Adult periodontitis as a model for rheumatoid arthritis (with emphasis on treatment strategies)Q78139394
AUTOIMMUNITY AND PERIODONTAL DISEASEQ78454289
Bacterial mechanisms in periodontal diseaseQ79320889
Comparison of second- and third-generation anti-cyclic citrullinated peptide antibodies assays for detecting rheumatoid arthritisQ81161393
Relationship of Actinobacillus actinomycetemcomitans serotypes to periodontal condition: prevalence and proportions in subgingival plaqueQ81366682
A comparative study of IgG second- and third-generation anti-cyclic citrullinated peptide (CCP) ELISAs and their combination with IgA third-generation CCP ELISA for the diagnosis of rheumatoid arthritisQ81972128
Antibody responses to periodontopathic bacteria in relation to rheumatoid arthritis in Japanese adultsQ83461326
The periodontium of periodontitis patients contains citrullinated proteins which may play a role in ACPA (anti-citrullinated protein antibody) formationQ83981705
Immunization with Porphyromonas gingivalis enolase induces autoimmunity to mammalian α-enolase and arthritis in DR4-IE-transgenic miceQ85001763
Expression of anti-Porphyromonas gingivalis peptidylarginine deiminase immunoglobulin G and peptidylarginine deiminase-4 in patients with rheumatoid arthritis and periodontitisQ85414597
Monodisperse and LPS-free Aggregatibacter actinomycetemcomitans leukotoxin: interactions with human β2 integrins and erythrocytesQ85647718
Editorial: citrullination, and carbamylation, and malondialdehyde-acetaldehyde! Oh my! Entering the forest of autoantigen modifications in rheumatoid arthritisQ86176899
Antibodies against Porphyromonas gingivalis in seropositive arthralgia patients do not predict development of rheumatoid arthritisQ87088550
The rheumatoid arthritis synovial fluid citrullinome reveals novel citrullinated epitopes in apolipoprotein E, myeloid nuclear differentiation antigen, and β-actinQ87417540
Insights into the significance of peptidylarginine deiminase 4 and antibodies against citrullinated antigens in the absence of "true ACPAs" in an experimental model of arthritis: comment on the article by Shelef et alQ88009534
The Microbiology of Early-Onset Periodontitis: Association of Highly Toxic Actinobacillus actinomycetemcomitans Strains With Localized Juvenile PeriodontitisQ88056761
The subgingival microbiome in patients with established rheumatoid arthritisQ88120619
The Rheumatoid Arthritis-Associated CitrullinomeQ88301749
Qualitative, quantitative and genotypic evaluation of Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum isolated from individuals with different periodontal clinical conditionsQ88950511
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Structure, function, and inhibition of a genomic/clinical variant of Porphyromonas gingivalis peptidylarginine deiminaseQ91025402
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Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritisQ36294995
Periodontitis increases rheumatic factor serum levels and citrullinated proteins in gingival tissues and alter cytokine balance in arthritic ratsQ36328094
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Impaired early B cell tolerance in patients with rheumatoid arthritis.Q36402969
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Concentration of antibodies against Porphyromonas gingivalis is increased before the onset of symptoms of rheumatoid arthritisQ37240538
Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis.Q37356818
Expression of peptidylarginine deiminase from Porphyromonas gingivalis in Escherichia coli: enzyme purification and characterizationQ37364691
Effects by periodontitis on pristane-induced arthritis in ratsQ37390960
Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis.Q37465513
Citrullination in the periodontium--a possible link between periodontitis and rheumatoid arthritis.Q37488177
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Serum antibody levels against Porphyromonas gingivalis in patients with and without rheumatoid arthritis - a systematic review and meta-analysisQ38937234
A Critical Reappraisal of Neutrophil Extracellular Traps and NETosis Mimics Based on Differential Requirements for Protein Citrullination.Q39014892
Cross-Sectional Evaluation of Periodontal Status and Microbiologic and Rheumatoid Parameters in a Large Cohort of Patients With Rheumatoid ArthritisQ39178292
Actinobacillus actinomycetemcomitans in human periodontal diseaseQ39814979
Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis.Q39903023
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P921main subjectrheumatoid arthritisQ187255
Aggregatibacter actinomycetemcomitansQ2174895
Porphyromonas gingivalisQ3214147
P577publication date2019-08-26
P1433published inJournal of Clinical MedicineQ27724774
P1476titleRheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans
P478volume8

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cites work (P2860)
Q92034749Autoantibodies and B Cells: The ABC of rheumatoid arthritis pathophysiology
Q94503268Outer membrane vesicle-mediated serum protection in Aggregatibacter actinomycetemcomitans
Q93270547PAD enzymes in rheumatoid arthritis: pathogenic effectors and autoimmune targets
Q89650535The microbiome in autoimmune rheumatic disease

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