Low polymorphisms in pfact, pfugt and pfcarl genes in African Plasmodium falciparum isolates and absence of association with susceptibility to common anti-malarial drugs

scientific article published on 28 August 2019

Low polymorphisms in pfact, pfugt and pfcarl genes in African Plasmodium falciparum isolates and absence of association with susceptibility to common anti-malarial drugs is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1186/S12936-019-2919-3
P932PMC publication ID6712813
P698PubMed publication ID31455301

P2093author name stringBruno Pradines
Joel Mosnier
Rémy Amalvict
French National Reference Centre for Imported Malaria Study Group
Nicolas Benoit
Raymond Bercion
Bécaye Fall
Marylin Madamet
Silman Diawara
Marie Gladys Robert
Mathieu Gendrot
Francis Tsombeng Foguim
Mamadou Wagué Gueye
P2860cites workSpread of artemisinin resistance in Plasmodium falciparum malariaQ21032481
Artemisinin Resistance in Plasmodium falciparum MalariaQ22061852
A molecular marker of artemisinin-resistant Plasmodium falciparum malariaQ22061872
The 'permeome' of the malaria parasite: an overview of the membrane transport proteins of Plasmodium falciparumQ24797363
Genetic markers associated with dihydroartemisinin-piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype-phenotype association studyQ27861941
UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genesQ27861953
Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug DiscoveryQ27861956
Comprehensive characterization of genes required for protein folding in the endoplasmic reticulumQ27937991
Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistanceQ29615118
Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy numberQ29615128
Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug ResistanceQ30047024
A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.Q30379780
Antimalarial Activity of KAF156 in Falciparum and Vivax MalariaQ33435505
Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from CambodiaQ33668137
KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmissionQ34057433
Use of the atmospheric generators for capnophilic bacteria Genbag-CO2 for the evaluation of in vitro Plasmodium falciparum susceptibility to standard anti-malarial drugsQ34541163
Directional selection at the pfmdr1, pfcrt, pfubp1, and pfap2mu loci of Plasmodium falciparum in Kenyan children treated with ACT.Q34563560
Artemisinin-based combination treatment of falciparum malaria.Q34731529
Efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine for treatment of uncomplicated malaria in children in Zaire and Uíge Provinces, angolaQ34922694
Multinormal in vitro distribution of Plasmodium falciparum susceptibility to piperaquine and pyronaridineQ35068138
Plasmodium falciparum susceptibility to standard and potential anti-malarial drugs in Dakar, Senegal, during the 2013-2014 malaria seasonQ35101288
Reduced in vitro susceptibility to artemisinin derivatives associated with multi-resistance in a traveller returning from South-East AsiaQ35257668
Influence of oxygen on asexual blood cycle and susceptibility of Plasmodium falciparum to chloroquine: requirement of a standardized in vitro assayQ35757486
Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: retrospective and prospective investigationsQ35875707
Assessing the potential impact of artemisinin and partner drug resistance in sub-Saharan AfricaQ36439747
Pfhrp2 and pfhrp3 polymorphisms in Plasmodium falciparum isolates from Dakar, Senegal: impact on rapid malaria diagnostic testsQ36608430
Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort studyQ36689509
Plasmodium falciparum In Vitro Resistance to Monodesethylamodiaquine, Dakar, Senegal, 2014.Q36884930
Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies.Q36919648
Prevalence of anti-malarial resistance genes in Dakar, Senegal from 2013 to 2014.Q37077079
Intermittent Preventive Treatment with Dihydroartemisinin-Piperaquine in Ugandan Schoolchildren Selects for Plasmodium falciparum Transporter Polymorphisms That Modify Drug SensitivityQ37287899
Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound ClassesQ37414137
Rapid decline in the susceptibility of Plasmodium falciparum to dihydroartemisinin-piperaquine in the south of VietnamQ37586458
A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype-genotype association studyQ37607320
Efficacy of artemether-lumefantrine, artesunate-amodiaquine, and dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum malaria in Angola, 2015.Q37623024
pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United KingdomQ37669829
Confirmation of Plasmodium falciparum in vitro resistance to monodesethylamodiaquine and chloroquine in Dakar, Senegal, in 2015.Q37708245
Treatment Failure of Dihydroartemisinin/Piperaquine for Plasmodium falciparum Malaria, VietnamQ37722332
Structural Biology of the Major Facilitator Superfamily TransportersQ38534222
West Africa International Centers of Excellence for Malaria Research: Drug Resistance Patterns to Artemether-Lumefantrine in Senegal, Mali, and The GambiaQ38973256
In vitro activities of antibiotics against Plasmodium falciparum are inhibited by ironQ39477444
Dihydroartemisinin-piperaquine failure associated with a triple mutant including kelch13 C580Y in Cambodia: an observational cohort studyQ39483732
Genetic diversity and structure of African Plasmodium falciparum populations in urban and rural areasQ39757934
Urban malaria in Dakar, Senegal: chemosusceptibility and genetic diversity of Plasmodium falciparum isolates.Q39762005
Partner-Drug Resistance and Population Substructuring of Artemisinin-Resistant Plasmodium falciparum in CambodiaQ40064790
Reliability of antimalarial sensitivity tests depends on drug mechanisms of action.Q40344256
pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparumQ41911870
Changing antimalarial drug sensitivities in UgandaQ41911931
Antibiotics for prophylaxis of Plasmodium falciparum infections: in vitro activity of doxycycline against Senegalese isolates.Q41921907
Impact of intermittent preventive treatment during pregnancy on Plasmodium falciparum drug resistance-mediating polymorphisms in UgandaQ41992238
Absence of association between polymorphisms in the K13 gene and the presence of Plasmodium falciparum parasites at day 3 after treatment with artemisinin derivatives in SenegalQ47992892
Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquineQ56342194
Absence of a High Level of Duplication of the Plasmepsin II Gene in AfricaQ57789692
Efficacy and safety of artemisinin-based combination therapy, and molecular markers for artemisinin and piperaquine resistance in Mainland TanzaniaQ58546525
Mutations in actin-binding protein coronin confer reduced artemisinin susceptibilityQ61717127
Baseline Ex Vivo and Molecular Responses of Plasmodium falciparum Isolates to Piperaquine before Implementation of Dihydroartemisinin-Piperaquine in SenegalQ91726552
P433issue1
P921main subjectmalariaQ12156
Plasmodium falciparumQ311383
P304page(s)293
P577publication date2019-08-28
P1433published inMalaria JournalQ15749954
P1476titleLow polymorphisms in pfact, pfugt and pfcarl genes in African Plasmodium falciparum isolates and absence of association with susceptibility to common anti-malarial drugs
P478volume18