Hyperactive Follicular Helper T Cells Contribute to Dysregulated Humoral Immunity in Patients With Liver Cirrhosis

scientific article published on 13 August 2019

Hyperactive Follicular Helper T Cells Contribute to Dysregulated Humoral Immunity in Patients With Liver Cirrhosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FIMMU.2019.01915
P932PMC publication ID6700335
P698PubMed publication ID31456809

P50authorMan HuangQ88343141
P2093author name stringQing He
Xin Zhao
Zheng Zhang
Zhiwei Li
Hongbo Wang
Mengmeng Qu
Juanjuan Zhao
Shuye Zhang
Zhenwen Liu
Jijing Shi
P2860cites workNatural killer cells in liver diseaseQ27025451
Causes of peripheral cytopenia in hepatitic cirrhosis and portal hypertensive splenomegalyQ33440201
Functional contribution of elevated circulating and hepatic non-classical CD14CD16 monocytes to inflammation and human liver fibrosisQ33604746
Presence of anti-microbial antibodies in liver cirrhosis--a tell-tale sign of compromised immunity?Q33707602
Dysfunctional B-cell activation in cirrhosis resulting from hepatitis C infection associated with disappearance of CD27-positive B-cell population.Q35633193
CXCR5+ CD4+ T follicular helper cells participate in the pathogenesis of primary biliary cirrhosisQ35867125
Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infectionQ36073682
Production of Autoantibodies in Chronic Hepatitis B Virus Infection Is Associated with the Augmented Function of Blood CXCR5+CD4+ T CellsQ36128625
Expansion of HIV-specific T follicular helper cells in chronic HIV infectionQ36190755
CXCL13 is a plasma biomarker of germinal center activityQ36684710
Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitmentQ37673234
Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-β-dependent emperipolesis in HBV cirrhotic patientsQ37698781
Cirrhosis-associated immune dysfunction: distinctive features and clinical relevanceQ38241149
Big spleens and hypersplenism: fix it or forget it?Q38259960
Human Circulating T Follicular Helper Cell Subsets in Health and DiseaseQ38777811
Endotoxemia contributes to CD27+ memory B-cell apoptosis via enhanced sensitivity to Fas ligation in patients with Cirrhosis.Q40447189
Advanced cirrhosis drives enhanced B-cell differentiation resulting in hyperglobulinemia.Q50050123
Evidence of neutrophil functional defect despite inflammation in stable cirrhosis.Q50548665
A comprehensive investigation on the distribution of circulating follicular T helper cells and B cell subsets in primary Sjögren's syndrome and systemic lupus erythematosus.Q50709967
Defective thymopoiesis and poor peripheral homeostatic replenishment of T-helper cells cause T-cell lymphopenia in cirrhosis.Q50897564
Sensing Microbial Viability through Bacterial RNA Augments T Follicular Helper Cell and Antibody Responses.Q52651611
Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses.Q52725593
The Janus Face of Follicular T Helper Cells in Chronic Viral Infections.Q54987756
A Portrait of CXCR5 Follicular Cytotoxic CD8 T cellsQ58112320
Human Extrafollicular CD4 Th Cells Help Memory B Cells Produce IgsQ58488172
Causes and Consequences of Innate Immune Dysfunction in CirrhosisQ64104715
Hypergammaglobulinemia and autoantibody induction mechanisms in viral infectionsQ73102242
Liver cirrhosisQ87200165
Exploiting vita-PAMPs in vaccinesQ89065038
Altered Microbiome in Patients With Cirrhosis and ComplicationsQ90896504
Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinibQ91556073
Structure and function of the immune system in the spleenQ92060086
T follicular helper cell heterogeneity: Time, space, and functionQ92382973
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectliver cirrhosisQ147778
P304page(s)1915
P577publication date2019-08-13
P1433published inFrontiers in ImmunologyQ27723748
P1476titleHyperactive Follicular Helper T Cells Contribute to Dysregulated Humoral Immunity in Patients With Liver Cirrhosis
P478volume10

Reverse relations

cites work (P2860)
Q100962274Metabolic defects in splenic B cell compartments from patients with liver cirrhosis
Q94464890Single-cell RNA sequencing reveals the heterogeneity of liver-resident immune cells in human

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