Targeting prosurvival BCL2 signaling through Akt blockade sensitizes castration-resistant prostate cancer cells to enzalutamide

scientific article published on 22 June 2019

Targeting prosurvival BCL2 signaling through Akt blockade sensitizes castration-resistant prostate cancer cells to enzalutamide is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/PROS.23843
P932PMC publication ID6617752
P698PubMed publication ID31228231

P2093author name stringClara Hwang
Amanda B Pilling
P2860cites workIAP Antagonists Enhance Apoptotic Response to Enzalutamide in Castration-Resistant Prostate Cancer Cells via Autocrine TNF-α SignalingQ38714695
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer modelsQ38736457
Enzalutamide, an androgen receptor signaling inhibitor, induces tumor regression in a mouse model of castration-resistant prostate cancerQ39139830
The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistanceQ39227285
TNF-alpha-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-X(L).Q39732156
Bcl-xL is overexpressed in hormone-resistant prostate cancer and promotes survival of LNCaP cells via interaction with proapoptotic Bak.Q40263616
A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignanciesQ46195208
Neoadjuvant Enzalutamide Prior to ProstatectomyQ46366990
Abiraterone acetate in combination with prednisone for the treatment of patients with metastatic castration-resistant prostate cancer: U.S. Food and Drug Administration drug approval summary.Q54710973
Activation of programmed cell death in the rat ventral prostate after castrationQ69816264
Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibitionQ88619003
Randomized Phase II Study Evaluating Akt Blockade with Ipatasertib, in Combination with Abiraterone, in Patients with Metastatic Prostate Cancer with and without PTEN LossQ90424840
Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancerQ24307748
Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome cQ24309066
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family membersQ24337108
Therapy escape mechanisms in the malignant prostateQ26795611
BH3 profiling--measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisionsQ26828031
Intense androgen-deprivation therapy with abiraterone acetate plus leuprolide acetate in patients with localized high-risk prostate cancer: results of a randomized phase II neoadjuvant studyQ27313709
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing plateletsQ27683708
Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.Q27851702
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machineryQ27860586
The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREBQ33959407
The androgen receptor mediates antiapoptotic function in myometrial cellsQ34007815
Targeting apoptosis in prostate cancerQ34348279
Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic LeukemiaQ34504188
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).Q35543223
Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancersQ35773657
Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737Q35779325
U.S. Food and Drug Administration Approval Summary: Enzalutamide for the Treatment of Patients With Chemotherapy-Naïve Metastatic Castration-Resistant Prostate CancerQ35915730
Phase I dose finding studies of obatoclax (GX15-070), a small molecule pan-BCL-2 family antagonist, in patients with advanced solid tumors or lymphomaQ36988067
The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism.Q37035832
Apoptosis and molecular targeting therapy in cancerQ38228349
P4510describes a project that usesImageJQ1659584
P433issue11
P921main subjectprostate cancerQ181257
P304page(s)1347-1359
P577publication date2019-06-22
P1433published inThe ProstateQ7758608
P1476titleTargeting prosurvival BCL2 signaling through Akt blockade sensitizes castration-resistant prostate cancer cells to enzalutamide
P478volume79

Reverse relations

cites work (P2860)
Q93155378Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis
Q99551795Resveratrol inhibits proliferation and promotes apoptosis via the androgen receptor splicing variant 7 and PI3K/AKT signaling pathway in LNCaP prostate cancer cells
Q94464833Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells

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