Identification of Novel Spx Regulatory Pathways in Bacillus subtilis Uncovers a Close Relationship between the CtsR and Spx Regulons

scientific article published on 10 June 2019

Identification of Novel Spx Regulatory Pathways in Bacillus subtilis Uncovers a Close Relationship between the CtsR and Spx Regulons is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JB.00151-19
P932PMC publication ID6560146
P698PubMed publication ID30962353

P50authorJohn D. HelmannQ30528126
Daniel Rojas-TapiasQ88897202
P2860cites workMcsB is a protein arginine kinase that phosphorylates and inhibits the heat-shock regulator CtsRQ27655749
Structural basis for recognizing phosphoarginine and evolving residue-specific protein phosphatases in gram-positive bacteriaQ27684831
Arginine phosphorylation marks proteins for degradation by a Clp proteaseQ27728478
The YjbH protein of Bacillus subtilis enhances ClpXP-catalyzed proteolysis of SpxQ28488899
YjbH-enhanced proteolysis of Spx by ClpXP in Bacillus subtilis is inhibited by the small protein YirB (YuzO)Q28488959
Requirement of the zinc-binding domain of ClpX for Spx proteolysis in Bacillus subtilis and effects of disulfide stress on ClpXP activityQ28489059
Dual negative control of spx transcription initiation from the P3 promoter by repressors PerR and YodB in Bacillus subtilisQ29346696
Phosphate starvation-inducible proteins of Bacillus subtilis: proteomics and transcriptional analysis.Q30888787
Adaptor bypass mutations of Bacillus subtilis spx suggest a mechanism for YjbH-enhanced proteolysis of the regulator Spx by ClpXPQ34024940
Crystal structure of the Bacillus subtilis anti-alpha, global transcriptional regulator, Spx, in complex with the alpha C-terminal domain of RNA polymerase.Q34098302
The RpoS-mediated general stress response in Escherichia coliQ34189650
Multiple pathways of Spx (YjbD) proteolysis in Bacillus subtilisQ34314108
Transcription from the P3 promoter of the Bacillus subtilis spx gene is induced in response to disulfide stressQ35759426
Global impact of protein arginine phosphorylation on the physiology of Bacillus subtilisQ35982784
Construction and Analysis of Two Genome-Scale Deletion Libraries for Bacillus subtilisQ36277847
Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in Bacillus subtilisQ37089682
Management of oxidative stress in BacillusQ37539907
Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteasesQ37553901
Regulation of CtsR Activity in Low GC, Gram+ BacteriaQ37809602
Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilisQ38327247
Activity-Based Profiling Reveals a Regulatory Link between Oxidative Stress and Protein Arginine PhosphorylationQ38436509
A tyrosine kinase and its activator control the activity of the CtsR heat shock repressor in B. subtilisQ39470175
The first gene of the Bacillus subtilis clpC operon, ctsR, encodes a negative regulator of its own operon and other class III heat shock genes.Q39569079
Exploring structure and interactions of the bacterial adaptor protein YjbH by crosslinking mass spectrometryQ39757341
Genome-wide identification of genes directly regulated by the pleiotropic transcription factor Spx in Bacillus subtilisQ41819717
Activity control of the ClpC adaptor McsB in Bacillus subtilisQ41831249
The tyrosine kinase McsB is a regulated adaptor protein for ClpCPQ42029485
SigM-responsive genes of Bacillus subtilis and their promotersQ42620182
Loss-of-function mutations in yjbD result in ClpX- and ClpP-independent competence development of Bacillus subtilisQ43796042
Redox-sensitive transcriptional control by a thiol/disulphide switch in the global regulator, Spx.Q45230251
The role of thiol oxidative stress response in heat-induced protein aggregate formation during thermotolerance in Bacillus subtilisQ46355450
Induction of the Spx regulon by cell wall stress reveals novel regulatory mechanisms in Bacillus subtilis.Q48358074
Multiple pathways for regulation of sigmaS (RpoS) stability in Escherichia coli via the action of multiple anti-adaptorsQ50063012
CtsR, a novel regulator of stress and heat shock response, controls clp and molecular chaperone gene expression in gram-positive bacteria.Q52179434
CtsR inactivation during thiol-specific stress in low GC, Gram+ bacteria.Q54622284
YjbH is a novel negative effector of the disulphide stress regulator, Spx, in Bacillus subtilisQ81379796
Regulated protein aggregation: a mechanism to control the activity of the ClpXP adaptor protein YjbHQ85889091
Stabilization of Bacillus subtilis Spx under cell wall stress requires the anti-adaptor protein YirBQ89997901
Spx, the central regulator of the heat and oxidative stress response in B. subtilis, can repress transcription of translation-related genesQ93337336
P433issue13
P921main subjectBacillus subtilisQ131238
P577publication date2019-06-10
P1433published inJournal of BacteriologyQ478419
P1476titleIdentification of Novel Spx Regulatory Pathways in Bacillus subtilis Uncovers a Close Relationship between the CtsR and Spx Regulons
P478volume201

Reverse relations

cites work (P2860)
Q89599501ClpP participates in stress tolerance, biofilm formation, antimicrobial tolerance, and virulence of Enterococcus faecalis
Q90441935Regulatory circuits controlling Spx levels in Streptococcus mutans
Q91743458Structural basis of non-canonical transcriptional regulation by the σA-bound iron-sulfur protein WhiB1 in M. tuberculosis

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