Targeting oxidative pentose phosphate pathway prevents recurrence in mutant Kras colorectal carcinomas

scientific article published on 28 August 2019

Targeting oxidative pentose phosphate pathway prevents recurrence in mutant Kras colorectal carcinomas is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PBIO.3000425
P932PMC publication ID6736310
P698PubMed publication ID31461438

P50authorQingQuan LiQ89287903
P2093author name stringTao Chen
Wei Zhang
Dong Wei
ChunFang Gao
WenChao Gao
XiuJuan Liu
ZhiQian Hu
ZunGuo Du
YuTing Xu
P2860cites workDynamic rerouting of the carbohydrate flux is key to counteracting oxidative stressQ21146753
Lysine glutarylation is a protein posttranslational modification regulated by SIRT5Q24293721
SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathwaysQ24296915
Reactive oxygen species in cancer stem cellsQ26849216
Pyruvate kinase M2 is a phosphotyrosine-binding proteinQ27650067
Global cancer statistics, 2012Q27860501
Interaction of CDCP1 with HER2 enhances HER2-driven tumorigenesis and promotes trastuzumab resistance in breast cancer.Q53220555
SIRT5 deacetylates and activates urate oxidase in liver mitochondria of miceQ57591351
Phosphoglucomutase kinetics with the phosphates of fructose, glucose, mannose, ribose, and galactoseQ72349071
Free radicals, antioxidants, and nutritionQ28205310
The catalytic mechanism of glutathione reductase as derived from x-ray diffraction analyses of reaction intermediatesQ28274498
Regulation of cancer cell metabolismQ28303890
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networksQ28588770
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycleQ28592294
On respiratory impairment in cancer cellsQ29617276
Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapyQ33344524
Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapyQ33675261
Quantitative flux analysis reveals folate-dependent NADPH production.Q33924205
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapseQ34171959
Colorectal cancer statistics, 2014.Q34660408
NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequencesQ34714532
The cell surface glycoprotein CDCP1 in cancer--insights, opportunities, and challengesQ34985908
Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells.Q35151497
Association between KRAS mutation and lung metastasis in advanced colorectal cancerQ35677827
Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal CancerQ35762264
Understanding cancer stem cell heterogeneity and plasticity.Q35796886
SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major TargetQ36064090
KRAS mutation influences recurrence patterns in patients undergoing hepatic resection of colorectal metastasesQ36071767
Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid OxidationQ36263068
Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent SurvivalQ36549632
Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patientsQ36653709
KRAS mutation leads to decreased expression of regulator of calcineurin 2, resulting in tumor proliferation in colorectal cancerQ37224269
Colon cancer stem cells: promise of targeted therapy.Q37737414
Cancer stem cells: current status and evolving complexitiesQ38019174
ALDH-positive lung cancer stem cells confer resistance to epidermal growth factor receptor tyrosine kinase inhibitorsQ39288061
Kinetic flux profiling for quantitation of cellular metabolic fluxesQ42235425
Altered growth of human colon cancer cell lines disrupted at activated Ki-rasQ42810367
Ultrahigh performance liquid chromatography-tandem mass spectrometry method for fast and robust quantification of anionic and aromatic metabolitesQ43078354
Isolation and phenotypic characterization of colorectal cancer stem cells with organ-specific metastatic potentialQ43452967
Control of the reactivation kinetics of homodimeric triosephosphate isomerase from unfolded monomers.Q44364893
Redox regulation of the G1 to S phase transition in the mouse embryo fibroblast cell cycle.Q44427363
Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase. The role of conserved residues and complementary mutations.Q45936959
Mass isotopomer study of the nonoxidative pathways of the pentose cycle with [1,2-13C2]glucose.Q46119052
FOXO3 Transcription Factor Is Essential for Protecting Hematopoietic Stem and Progenitor Cells from Oxidative DNA DamageQ46443231
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P304page(s)e3000425
P577publication date2019-08-28
P1433published inPLOS BiologyQ1771695
P1476titleTargeting oxidative pentose phosphate pathway prevents recurrence in mutant Kras colorectal carcinomas
P478volume17

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Q100391105SIRT5 deficiency enhances the proliferative and therapeutic capacities of adipose-derived mesenchymal stem cells via metabolic switchingcites workP2860