Hypoxic Regulation of Neutrophils in Cancer

scientific article published on 27 August 2019

Hypoxic Regulation of Neutrophils in Cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3390/IJMS20174189
P953full work available online athttps://www.mdpi.com/1422-0067/20/17/4189
P932PMC publication ID6747474
P698PubMed publication ID31461847

P2093author name stringYatrik M Shah
Daniel Triner
Yatrik M. Shah
P2860cites workNeutrophil infiltration is a favorable prognostic factor in early stages of colon cancerQ47838906
Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population.Q54616861
Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosisQ57608179
Hypoxia induces endothelial cells to increase their adherence for neutrophils: role of PAFQ67567219
Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cellsQ73229815
Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in MiceQ90503326
A Positive Feedback Loop Between Cancer Stem-Like Cells and Tumor-Associated Neutrophils Controls Hepatocellular Carcinoma ProgressionQ92747215
Hallmarks of Cancer: The Next GenerationQ22252312
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic nicheQ24606366
Hypoxia-Inducible Factors in Physiology and MedicineQ27013770
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer modelsQ27727998
The blockade of immune checkpoints in cancer immunotherapyQ27860852
Tumor entrained neutrophils inhibit seeding in the premetastatic lungQ28247691
Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growthQ28270711
Hypoxia upregulates neutrophil degranulation and potential for tissue injuryQ28596234
HIF-1alpha is essential for myeloid cell-mediated inflammationQ29617581
Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TANQ29619346
PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activationQ33569771
Generation of a new therapeutic peptide that depletes myeloid-derived suppressor cells in tumor-bearing miceQ33721765
Circulating human peripheral blood granulocytes synthesize and secrete tumor necrosis factor alphaQ33771233
Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter miceQ33927482
Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammationQ34028645
Transcriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal NeutrophilsQ34163579
Macrophages are recruited to hypoxic tumor areas and acquire a pro-angiogenic M2-polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and EotaxinQ34221784
Myeloid derived hypoxia inducible factor 1-alpha is required for protection against pulmonary Aspergillus fumigatus infectionQ34257883
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.Q34429912
Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesisQ34928194
HIF transcription factors, inflammation, and immunityQ35137138
IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasisQ35763387
MET is required for the recruitment of anti-tumoural neutrophilsQ36125652
Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesisQ36190681
TNF signaling drives myeloid-derived suppressor cell accumulationQ36357903
Epithelial exposure to hypoxia modulates neutrophil transepithelial migrationQ36367344
Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activityQ36402484
Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitisQ36404110
Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor CellsQ36422289
Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expressionQ36672331
The prognostic landscape of genes and infiltrating immune cells across human cancersQ36857285
Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinomaQ36943936
Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma CellsQ37031596
HIF2α-arginase axis is essential for the development of pulmonary hypertension.Q37161630
Endothelial PAS domain protein 1 activates the inflammatory response in the intestinal epithelium to promote colitis in miceQ37237823
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.Q37489023
Neutrophils: key mediators of tumour angiogenesisQ37534968
CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesisQ37591247
Prognostic significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with stage III and IV colorectal cancerQ37624508
Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammationQ37633213
Targeting renal cell carcinoma with a HIF-2 antagonist.Q37684974
Inflammation and colon cancerQ37737408
Hypoxia-inducible factors in regulation of immune responses in tumour microenvironmentQ38246724
Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer.Q38413010
Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responsesQ38626160
Pre-metastatic niches: organ-specific homes for metastases.Q38743711
Neutrophils in cancer: neutral no more.Q38860382
Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer.Q38916509
Neutrophils recruit regulatory T-cells into tumors via secretion of CCL17--a new mechanism of impaired antitumor immunityQ39026688
Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progressionQ39087629
Epithelial Hypoxia-Inducible Factor 2α Facilitates the Progression of Colon Tumors through Recruiting NeutrophilsQ39107166
Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps.Q39231400
Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche.Q39321728
Inhibition of the Kit ligand/c-Kit axis attenuates metastasis in a mouse model mimicking local breast cancer relapse after radiotherapy.Q39328708
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells.Q39507131
Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathwayQ40266970
Hypoxia-inducible factors: a central link between inflammation and cancerQ41678975
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and miceQ41984558
Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancerQ42157682
HIF-1alpha expression regulates the bactericidal capacity of phagocytesQ42876119
Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity.Q46373208
Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation modelQ46433930
Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathwayQ47159175
Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell CarcinomaQ47283034
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectoxygenQ629
neutrophilQ188417
neoplasmQ1216998
P304page(s)4189
P577publication date2019-01-01
2019-08-27
P13046publication type of scholarly workreview articleQ7318358
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleHypoxic Regulation of Neutrophils in Cancer
P478volume20

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