A rat model of severe VWD by elimination of the VWF gene using CRISPR/Cas9

scientific article published on 29 December 2019

A rat model of severe VWD by elimination of the VWF gene using CRISPR/Cas9 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/RTH2.12280
P932PMC publication ID6971331
P698PubMed publication ID31989086

P2093author name stringAron M Geurts
Robert R Montgomery
Hartmut Weiler
Sandra L Haberichter
Veronica H Flood
Qizhen Shi
Jessica Garcia
Scot A Fahs
Mark Zogg
Jeremy G Mattson
P2860cites workBiochemistry and genetics of von Willebrand factorQ22003890
Genome engineering using the CRISPR-Cas9 systemQ22122027
Multiplex genome engineering using CRISPR/Cas systemsQ24609428
A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosisQ28586884
Insights from von Willebrand disease animal modelsQ28592716
Thrombotic thrombocytopenia induced in dogs and pigs. The role of plasma and platelet vWF in animal models of thrombotic thrombocytopenic purpuraQ33489821
Platelets have more than one binding site for von Willebrand factorQ33821754
Crucial role for the VWF A1 domain in binding to type IV collagenQ35252688
Intravascular recovery of VWF and FVIII following intraperitoneal injection and differences from intravenous and subcutaneous injection in miceQ35881502
Hemostatic efficacy, safety, and pharmacokinetics of a recombinant von Willebrand factor in severe von Willebrand diseaseQ36193201
von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA).Q37100261
Collagen binding provides a sensitive screen for variant von Willebrand diseaseQ37367262
Intracellular trafficking of factor VIII to von Willebrand factor storage granulesQ37377963
Gene deletions correlate with the development of alloantibodies in von Willebrand diseaseQ40922128
Evaluation of recombinant von Willebrand factor in a canine model of von Willebrand diseaseQ45856650
A novel F8 -/- rat as a translational model of human hemophilia A.Q45865994
Clinical manifestations and complications of childbirth and replacement therapy in 385 Iranian patients with type 3 von Willebrand diseaseQ45874158
Isolation and characterization of two domains of human von Willebrand factor that interact with fibrillar collagen types I and III.Q45936667
Differential distribution of von Willebrand factor in endothelial cells. Comparison between normal pigs and pigs with von Willebrand diseaseQ68933421
Studies with a murine monoclonal antibody that abolishes ristocetin-induced binding of von Willebrand factor to platelets: additional evidence in support of GPIb as a platelet receptor for von Willebrand factorQ70237272
Pharmacokinetics of von Willebrand factor and factor VIIIC in patients with severe von Willebrand disease (type 3 VWD): estimation of the rate of factor VIIIC synthesis. Cooperative Study GroupsQ71579909
Rat Genome Databases, Repositories, and ToolsQ92951348
P4510describes a project that usesCRISPR-Cas methodQ17310682
P433issue1
P921main subjectCRISPRQ412563
Cas9Q16965677
CRISPR-Cas methodQ17310682
P304page(s)64-71
P577publication date2019-12-29
P1433published inResearch and Practice in Thrombosis and HaemostasisQ50817799
P1476titleA rat model of severe VWD by elimination of the VWF gene using CRISPR/Cas9
P478volume4

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