Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

scientific article published on 08 November 2018

Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S2213-2600(18)30406-5
P698PubMed publication ID30416083

P50authorRichard OlssonQ42810536
Eugene R BleeckerQ65560413
P2093author name stringPeter Barker
William W Busse
J Mark FitzGerald
Gary T Ferguson
Ubaldo J Martin
Mitchell Goldman
BORA study investigators
Stephanie Sproule
P2860cites workGlobal asthma prevalence in adults: findings from the cross-sectional world health surveyQ34201679
The poorly explored impact of uncontrolled asthmaQ34326184
Oral Glucocorticoid-Sparing Effect of Benralizumab in Severe AsthmaQ34557028
Sputum eosinophilia is a determinant of FEV1 decline in occupational asthma: results of an observational studyQ34903683
Biologic therapies targeting eosinophils: current status and future prospectsQ35565533
Tissue and BAL based biomarkers in asthmaQ36998180
The consequences of not having eosinophils.Q37561562
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthmaQ38171268
Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trialQ39408906
Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trialQ45297326
Predictors of enhanced response with benralizumab for patients with severe asthma: pooled analysis of the SIROCCO and CALIMA studiesQ50053497
The association between blood eosinophil count and benralizumab efficacy for patients with severe, uncontrolled asthma: subanalyses of the Phase III SIROCCO and CALIMA studies.Q51345374
Reductions in eosinophil biomarkers by benralizumab in patients with asthma.Q53641303
MEDI-563, a humanized anti–IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity functionQ60632052
P433issue1
P921main subjectasthmaQ35869
phase III clinical trialQ42824827
P304page(s)46-59
P577publication date2018-11-08
P1433published inThe Lancet. Respiratory medicineQ27724908
P1476titleLong-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial
P478volume7

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cites work (P2860)
Q900405042020 Brazilian Thoracic Association recommendations for the management of asthma
Q95273637COVID-19, asthma, and biologic therapies: What we need to know
Q64113098Efficacy and steroid-sparing effect of benralizumab: has it an advantage over its competitors?
Q94446722Eosinophil Responses During COVID-19 Infections and Coronavirus Vaccination
Q92536062Interleukin-5 in the Pathophysiology of Severe Asthma
Q89481425Intersection of biology and therapeutics: type 2 targeted therapeutics for adult asthma
Q90330860NSAID-ERD Syndrome: the New Hope from Prevention, Early Diagnosis, and New Therapeutic Targets
Q92696109New horizons for the treatment of severe, eosinophilic asthma: benralizumab, a novel precision biologic
Q104567544Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial
Q91657123Rapid Effect of Benralizumab for Hypereosinophilia in a Case of Severe Asthma with Eosinophilic Chronic Rhinosinusitis
Q89670380Severe Asthma and Biological Therapy: When, Which, and for Whom
Q93081762Severe Eosinophilic Asthma
Q92485478Targeting eosinophils: severe asthma and beyond
Q92068607Two-Year Integrated Efficacy And Safety Analysis Of Benralizumab In Severe Asthma

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