DNA repair in cancer initiation, progression, and therapy-a double-edged sword

scientific article published on 30 August 2019

DNA repair in cancer initiation, progression, and therapy-a double-edged sword is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1007/S13353-019-00516-9
P932PMC publication ID6803590
P698PubMed publication ID31468363

P50authorKrzysztof SzyfterQ22114906
Katarzyna KiwerskaQ59159574
P2860cites workDouble-strand break repair-adox: Restoration of suppressed double-strand break repair during mitosis induces genomic instabilityQ26991670
Targeting DNA damage response in cancer therapyQ27023204
p53 coordinates base excision repair to prevent genomic instabilityQ28834500
The cancer genomeQ29547643
Defective mismatch repair, microsatellite mutation bias, and variability in clinical cancer phenotypesQ33596701
DNA damage response--a double-edged sword in cancer prevention and cancer therapyQ34454975
DNA repair gene variants in relation to overall cancer risk: a population-based studyQ36499747
Restoration of wild-type p53 function in human cancer: relevance for tumor therapy.Q36710840
Overexpression of DNA repair genes is associated with metastasis: a new hypothesisQ37097570
Platinum resistance: the role of DNA repair pathwaysQ37100598
Cancers exhibit a mutator phenotype: clinical implicationsQ37165106
DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosisQ37977244
DNA damage and gene therapy of xeroderma pigmentosum, a human DNA repair-deficient diseaseQ38563227
Increased ERCC1 expression is linked to chromosomal aberrations and adverse tumor biology in prostate cancerQ38659673
Removal of oxidatively generated DNA damage by overlapping repair pathwaysQ39000410
Regulatory players of DNA damage repair mechanisms: Role in Cancer ChemoresistanceQ39454681
Genetic variants in ERCC1 and XPC predict survival outcome of non-small cell lung cancer patients treated with platinum-based therapyQ41636798
Misregulation of DNA damage repair pathways in HPV-positive head and neck squamous cell carcinoma contributes to cellular radiosensitivityQ42244844
Association of XRCC1 genetic polymorphism (Arg399Gln) with laryngeal cancer: a meta-analysis based on 4,031 subjectsQ43547587
Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancersQ44767574
Repairing DNA for 80 years: the timeline of my lifeQ46114897
The impacts of genetic polymorphisms in genes of base excision repair pathway on the efficacy and acute toxicities of (chemo)radiotherapy in patients with nasopharyngeal carcinomaQ46140928
Radiation-induced unrepairable DSBs: their role in the late effects of radiation and possible applications to biodosimetryQ49557385
Reduced expression of mismatch repair genes MSH6/MSH2 directly promotes pituitary tumor growth via the ATR-Chk1 pathwayQ50000976
DNA base excision repair proteins APE-1 and XRCC-1 are overexpressed in oral tongue squamous cell carcinoma.Q51281400
Genomic Instability Promoted by Overexpression of Mismatch Repair Factors in Yeast: A Model for Understanding Cancer Progression.Q52589171
Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas.Q52607320
Polymorphisms in DNA mismatch repair pathway genes predict toxicity and response to cisplatin chemoradiation in head and neck squamous cell carcinoma patientsQ57177355
Effects of polymorphic DNA genes involved in BER and caspase pathways on the clinical outcome of myeloproliferative neoplasms under treatment with hydroxyureaQ57481863
Base excision repair capacity as a determinant of prognosis and therapy response in colon cancer patientsQ57486087
Appropriate Sequence for Afatinib and Cisplatin Combination Improves Anticancer Activity in Head and Neck Squamous Cell CarcinomaQ57818008
Excision repair cross-complementing group 1 (ERCC1) overexpression inhibits cell apoptosis and is associated with unfavorable prognosis of esophageal squamous cell carcinomaQ58802064
rs1799782 (C194T) polymorphism correlated with tumor metastasis and molecular subtypes in breast cancerQ60049551
Polymorphism of DNA repair genes in breast cancerQ61796811
Targeting DNA Double-Strand Break Repair Pathways to Improve Radiotherapy ResponseQ61805942
A MLH1 polymorphism that increases cancer risk is associated with better outcome in sporadic colorectal cancerQ84372981
Association of C722T polymorphism in XRCC3 gene with larynx cancer: a meta-analysisQ87283567
Inherent and toxicant-provoked reduction in DNA repair capacity: A key mechanism for personalized risk assessment, cancer prevention and intervention, and response to therapyQ90449251
The Clinical Impact of the Genomic Landscape of Mismatch Repair-Deficient CancersQ93159717
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P433issue3-4
P407language of work or nameEnglishQ1860
P921main subjectdysplasiaQ1128996
neoplasm DNAQ71515340
P304page(s)329-334
P577publication date2019-08-30
2019-11-01
P1433published inJournal of Applied GeneticsQ15767059
P1476titleDNA repair in cancer initiation, progression, and therapy-a double-edged sword
P478volume60

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Q109919922Cancer as a prospective sequela of long COVID‐19cites workP2860

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