Gap Junctions in the Bone Marrow Lympho-Hematopoietic Stem Cell Niche, Leukemia Progression, and Chemoresistance

scientific article published on 25 January 2020

Gap Junctions in the Bone Marrow Lympho-Hematopoietic Stem Cell Niche, Leukemia Progression, and Chemoresistance is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/IJMS21030796
P932PMC publication ID7038046
P698PubMed publication ID31991829

P2093author name stringJose A Cancelas
Abhishek K Singh
P2860cites workDynamic trafficking and delivery of connexons to the plasma membrane and accretion to gap junctions in living cellsQ24533504
Intercellular communication in the immune system: differential expression of connexin40 and 43, and perturbation of gap junction channel functions in peripheral blood and tonsil human lymphocyte subpopulationsQ24642743
Connexin43 gap junctions in normal, regenerating, and cultured mouse bone marrow and in human leukemias: their possible involvement in blood formationQ24678387
Differential expression of novel potential regulators in hematopoietic stem cellsQ24811837
Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow nicheQ28505006
Functional role of gap junctions in cytokine-induced leukocyte adhesion to endothelium in vivoQ28506489
Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodelingQ28592164
Tales of a Dirty Drug: Carbenoxolone, Gap Junctions, and SeizuresQ28972313
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cellsQ29615006
Osteoblastic cells regulate the haematopoietic stem cell nicheQ29615007
Mesenchymal and haematopoietic stem cells form a unique bone marrow nicheQ29616602
Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell nichesQ29617460
Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in miceQ30307679
Mitochondrial transfer between cells can rescue aerobic respirationQ30476644
Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctionsQ30479975
Connexins modulate autophagosome biogenesisQ30577497
Gap junction intercellular communication during lymphocyte transendothelial migrationQ30703122
Angiotensin II Regulation of Proliferation, Differentiation, and Engraftment of Hematopoietic Stem CellsQ30711427
Up-regulation of Cx43 expression and GJIC function in acute leukemia bone marrow stromal cells post-chemotherapyQ30883866
Adhesion of human hematopoietic progenitor cells to mesenchymal stromal cells involves CD44.Q33312423
Bone marrow connexin-43 expression is critical for hematopoietic regeneration after chemotherapyQ33370523
Acute myeloid leukemia does not deplete normal hematopoietic stem cells but induces cytopenias by impeding their differentiationQ33409425
Endothelial Cells Promote Expansion of Long-Term Engrafting Marrow Hematopoietic Stem and Progenitor Cells in PrimatesQ33722264
p53 regulates hematopoietic stem cell quiescence.Q33732098
CD4+ T lymphocyte subsets express connexin 43 and establish gap junction channel communication with macrophages in vitro.Q33761855
Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cellsQ33837223
Connexin43 mediates direct intercellular communication in human osteoblastic cell networksQ33898016
Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient boneQ34012735
Human primary endothelial cells stimulate human osteoprogenitor cell differentiationQ40523937
Connexin expression and gap-junction-mediated cell interactions in an in vitro model of haemopoietic stroma.Q40589111
Fusion of GFP to the carboxyl terminus of connexin43 increases gap junction size in HeLa cellsQ40606454
Connexin-43 interactions with ZO-1 and alpha- and beta-tubulinQ40725280
Gap junction protein connexin-43 interacts directly with microtubulesQ40781090
The origin of annular junctions: a mechanism of gap junction internalizationQ40828189
Hepatocyte growth factor is secreted by osteoblasts and cooperatively permits the survival of haematopoietic progenitors.Q40828878
Intercellular communication between bone marrow stromal cells and CD34+ haematopoietic progenitor cells is mediated by connexin 43-type gap junctionsQ40836620
Connexin-43 gap junctions are involved in multiconnexin-expressing stromal support of hemopoietic progenitors and stem cellsQ40869443
Cardiac intercellular communication: consequences of connexin distribution and diversityQ40922017
Gap junctions in blood forming tissuesQ40930969
Mesenchymal stem cells sense mitochondria released from damaged cells as danger signals to activate their rescue propertiesQ41078616
Connexins, connexons, and intercellular communicationQ41114815
Multiple connexin proteins in single intercellular channels: connexin compatibility and functional consequencesQ41141420
Bone Marrow Macrophages Contribute to Diabetic Stem Cell Mobilopathy by Producing Oncostatin M.Q41169174
Are there functional gap junctions or junctional hemichannels in macrophages?Q41189158
Connexin-43-type gap junctions mediate communication between bone marrow stromal cells.Q41543729
Formation of B type gap junctions between PHA-stimulated rabbit lymphocytesQ41555211
Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injuryQ42128038
Autophagy maintains the metabolism and function of young and old stem cells.Q42317229
Control of the proliferation of activated CD4+ T cells by connexinsQ43127224
CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenanceQ43226905
Connexon integrity is maintained by non-covalent bonds: intramolecular disulfide bonds link the extracellular domains in rat connexin-43.Q43517108
Immunoglobulin and cytokine expression in mixed lymphocyte cultures is reduced by disruption of gap junction intercellular communicationQ43548115
Direct cell-cell communication in the blood-forming systemQ43867901
Sl/Sld mice have an increased number of gap junctions in their bone marrow stromal cellsQ43904595
Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteinsQ44117862
Hematopoietic capacity of connexin43 wild-type and knock-out fetal liver cells not different on wild-type stromaQ44240273
TNF-alpha plus IFN-gamma induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responsesQ44285411
Enhancement of repopulation haemopoiesis by heterozygous connexin 43 stem cells seeded on wild-type connexin 43 stromaQ44498865
Ultrastructural morphometric study of efferent nerve terminals on murine bone marrow stromal cells, and the recognition of a novel anatomical unit: the "neuro-reticular complex".Q44772551
Extracellular nucleotides are potent stimulators of human hematopoietic stem cells in vitro and in vivoQ44909366
Osteoblasts promote engraftment of allogeneic hematopoietic stem cellsQ46292035
Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis.Q46456469
Distinct bone marrow blood vessels differentially regulate haematopoiesis.Q46564265
Endothelial jagged-2 sustains hematopoietic stem and progenitor reconstitution after myelosuppressionQ47421531
Cx30 exhibits unique characteristics including a long half-life when assembled into gap junctionsQ50351931
Cx25 contributes to leukemia cell communication and chemosensitivity.Q34044927
Adenovirus vector E4 gene regulates connexin 40 and 43 expression in endothelial cells via PKA and PI3K signal pathwaysQ34109505
Multicolor and electron microscopic imaging of connexin traffickingQ34124663
Regulatory pathways in blood-forming tissue with particular reference to gap junctional communicationQ34138184
Hematopoiesis is severely altered in mice with an induced osteoblast deficiencyQ34290169
Multisubunit assembly of an integral plasma membrane channel protein, gap junction connexin43, occurs after exit from the ERQ34306752
NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts.Q34558873
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell nicheQ34577717
p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-κB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche.Q34777301
Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT₂R and cytoskeletal dysregulation.Q34940868
Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cellsQ34957840
Gap junctions and connexins: potential contributors to the immunological synapseQ34961018
Connexin expression in human acute myeloid leukemia cells: identification of patient subsets based on protein and global gene expression profilesQ35040043
Inhibition of GSK-3β rescues the impairments in bone formation and mechanical properties associated with fracture healing in osteoblast selective connexin 43 deficient miceQ35049558
Gap junctions between human T-colony cellsQ35174667
Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemiaQ35564841
Gap junctions and connexin-mediated communication in the immune systemQ35700140
Endothelial and perivascular cells maintain haematopoietic stem cellsQ35724815
Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation.Q35729489
Gap junctions and the connexin protein familyQ35749952
Pathways for degradation of connexins and gap junctions.Q35749961
Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated miceQ35750865
VCAM-1 expression in adult hematopoietic and nonhematopoietic cells is controlled by tissue-inductive signals and reflects their developmental origin.Q35847871
Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors.Q36014990
Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cellsQ36061498
All-trans retinoic acid arrests cell cycle in leukemic bone marrow stromal cells by increasing intercellular communication through connexin 43-mediated gap junctionQ36134845
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradationQ36162592
Detection of gap junctions between the progeny of a canine macrophage colony-forming cell in vitroQ36200866
Pathways and control of connexin oligomerization.Q36401843
Expression of connexin 32 and connexin 43 in acute myeloid leukemia and their roles in proliferationQ36403429
Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool sizeQ36403763
Gap‐Junction Communication Pathways in Germinal Center ReactionsQ36511307
Immunohistological detection of gap junctions in human lymphoid tissue: connexin43 in follicular dendritic and lymphoendothelial cellsQ36681938
Increased expression of CX43 on stromal cells promotes leukemia apoptosisQ36688963
Connexin 43 Modulates Osteogenic Differentiation of Bone Marrow Stromal Cells Through GSK-3beta/Beta-Catenin Signaling PathwaysQ88680551
Myelopoiesis in the Context of Innate ImmunityQ89011465
Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stressQ90000799
PGC-1α driven mitochondrial biogenesis in stromal cells underpins mitochondrial trafficking to leukemic blastsQ90376250
CD38-Driven Mitochondrial Trafficking Promotes Bioenergetic Plasticity in Multiple MyelomaQ90949081
Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIXQ90965346
Connexin43 regulates osteoprotegerin expression via ERK1/2 -dependent recruitment of Sp1Q90968649
Correction: Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cellsQ91174407
The Yin and Yang of the Bone Marrow Microenvironment: Pros and Cons of Mesenchymal Stromal Cells in Acute Myeloid LeukemiaQ91219461
ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infectionQ91286420
Apelin+ Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative InjuryQ91422158
Haematopoietic stem cell activity and interactions with the nicheQ91468445
The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial ClearanceQ92229587
Signaling Pathways Regulating Hematopoietic Stem Cell and Progenitor AgingQ92892162
Bone marrow adherent layers inhibit apoptosis of acute myeloid leukemia cells.Q36726478
Cell-cell communication in the osteoblast/osteocyte lineage.Q36740282
Osteoblast and osteocyte‐specific loss of Connexin43 results in delayed bone formation and healing during murine fracture healingQ36807175
The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activationQ36925362
SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitorsQ37078786
Osteal macrophages: a new twist on coupling during bone dynamicsQ37286721
Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance.Q37511781
Cx43 expressed on bone marrow stromal cells plays an essential role in multiple myeloma cell survival and drug resistanceQ37549419
High bone mass in mice lacking Cx37 because of defective osteoclast differentiationQ37653316
A niche-like culture system allowing the maintenance of primary human acute myeloid leukemia-initiating cells: a new tool to decipher their chemoresistance and self-renewal mechanismsQ37681007
Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cellsQ37723101
Evolutionary analyses of gap junction protein familiesQ37988232
The sixth sense: hematopoietic stem cells detect danger through purinergic signalingQ38025606
Mix and match: investigating heteromeric and heterotypic gap junction channels in model systems and native tissuesQ38190331
Emergency granulopoiesisQ38206076
Leukemogenic AML1-ETO fusion protein upregulates expression of connexin 43: the role in AML 1-ETO-induced growth arrest in leukemic cellsQ38312651
Connexins: Intercellular Signal Transmitters in Lymphohematopoietic Tissues.Q38575569
Connexin 43 is required for the maintenance of mitochondrial integrity in brown adipose tissue.Q38645888
Communication of Ca(2+) signals via tunneling membrane nanotubes is mediated by transmission of inositol trisphosphate through gap junctionsQ38759284
B-cell precursor acute lymphoblastic leukemia cells use tunneling nanotubes to orchestrate their microenvironmentQ38841779
Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapyQ38858729
Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA.Q38922496
Up-regulation of connexin-43 expression in bone marrow mesenchymal stem cells plays a crucial role in adhesion and migration of multiple myeloma cellsQ39005146
Adult haematopoietic stem cell nichesQ39366652
Effect of Cx43 gene-modified leukemic bone marrow stromal cells on the regulation of Jurkat cell line in vitroQ39452161
Energy metabolism of leukemia cells: glycolysis versus oxidative phosphorylation.Q39652880
Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cellsQ39903574
Activated macrophages inhibit enterocyte gap junctions via the release of nitric oxideQ40059029
Establishing long-term cultures with self-renewing acute myeloid leukemia stem/progenitor cells.Q40077330
Connexin37 protects against atherosclerosis by regulating monocyte adhesionQ40252212
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cellsQ40299682
Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor DifferentiationQ40444284
Gap junctions in hematopoietic stroma control proliferation and differentiation of blood cell precursorsQ40488934
Alteration Analysis of Bone Marrow Mesenchymal Stromal Cells from De Novo Acute Myeloid Leukemia Patients at DiagnosisQ50445214
Does transmembrane communication through gap junctions enable stem cells to overcome stromal inhibition?Q52193295
Up-regulation of the connexin43+ gap junction network in haemopoietic tissue before the growth of stem cells.Q52219664
Gap junctions between cells of bone marrow: an ultrastructural study using tannic acidQ52299852
Niches for Hematopoietic Stem Cells and Their ProgenyQ52317346
Protective role of connexin 32 in steady-state hematopoiesis, regeneration state, and leukemogenesisQ53556975
Regulation of osteoclastogenesis by gap junction communicationQ53625746
Vascular endothelial cells produce soluble factors that mediate the recovery of human hematopoietic stem cells after radiation injuryQ53625988
Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCsQ54415335
Gap junctional communication is involved in differentiation of osteoclasts from bone marrow and peripheral blood monocytes.Q55019516
Therapeutic strategies targeting connexinsQ57471977
Connexin 43-Mediated Mitochondrial Transfer of iPSC-MSCs Alleviates Asthma InflammationQ57814615
Human osteoblasts support human hematopoietic progenitor cells in vitro bone marrow culturesQ60504433
Amplification of mitochondrial DNA in acute myeloid leukaemiaQ63248800
Haematopoiesis in the era of advanced single-cell technologiesQ64008432
CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions.Q64883908
Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration.Q64922350
Ultrastructural and morphometric alterations in bone marrow stromal tissue after 7 Gy irradiationQ67801685
Possible communication between murine macrophages oriented in linear chains in tissue cultureQ68210387
A comparative morphometric study on the ultrastructure of adherent cells in long-term bone marrow culture from normal and congenitally anemic miceQ69693099
A study of intercellular relationships between trabecular bone and marrow stromal cells in the murine femoral metaphysisQ71554517
Bone marrow stromal cell blockade of human leukemic cell differentiationQ71619532
Functional gap junctions in thymic epithelial cells are formed by connexin 43Q72589366
Posttranslational phosphorylation of lens fiber connexin46: a slow occurrenceQ72650857
Direct cell/cell communication in the lymphoid germinal center: connexin43 gap junctions functionally couple follicular dendritic cells to each other and to B lymphocytesQ73481235
Detection and characterization of primitive malignant and normal progenitors in patients with acute myelogenous leukemia using long-term coculture with supportive feeder layers and cytokinesQ73774745
Connexin45 interacts with zonula occludens-1 and connexin43 in osteoblastic cellsQ73785250
Bone marrow stroma inhibits proliferation and apoptosis in leukemic cells through gap junction-mediated cell communicationQ73839468
Hematopoiesis: Gap Junction Intercellular Communication is Likely to be Involved in Regulation of Stroma-dependent Proliferation of Hemopoietic Stem CellsQ74000673
Expression of connexin 43 (Cx43) is critical for normal hematopoiesisQ74055050
Membrane channel connexin 32 maintains Lin(-)/c-kit(+) hematopoietic progenitor cell compartment: analysis of the cell cycleQ80608548
Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cellsQ81676385
Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistanceQ85243285
Connexin 43 expressed in endothelial cells modulates monocyte‑endothelial adhesion by regulating cell adhesion proteinsQ86042232
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P921main subjectstem cell nicheQ16729831
P577publication date2020-01-25
P13046publication type of scholarly workreview articleQ7318358
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleGap Junctions in the Bone Marrow Lympho-Hematopoietic Stem Cell Niche, Leukemia Progression, and Chemoresistance
P478volume21

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