How structural subtleties lead to molecular diversity for the type III polyketide synthases

scientific article published on 30 August 2019

How structural subtleties lead to molecular diversity for the type III polyketide synthases is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1074/JBC.REV119.006129
P932PMC publication ID6791334
P698PubMed publication ID31471316

P50authorIkuro AbeQ52314593
P2093author name stringHiroyuki Morita
Chin Piow Wong
P2860cites workExploiting the Biosynthetic Potential of Type III Polyketide SynthasesQ26747526
PqsBC, a Condensing Enzyme in the Biosynthesis of thePseudomonas aeruginosaQuinolone SignalQ27312117
Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesisQ27619215
Structural control of polyketide formation in plant-specific polyketide synthasesQ27629136
Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificityQ27638871
Structural insight into chain-length control and product specificity of pentaketide chromone synthase from Aloe arborescensQ27644615
A structure-based mechanism for benzalacetone synthase from Rheum palmatumQ27659004
Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativaQ27665538
Crystal structure of curcuminoid synthase CUS from Oryza sativaQ27666119
Synthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthaseQ27671626
Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativaQ27703635
The chalcone synthase superfamily of type III polyketide synthasesQ28183088
Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketidesQ28271259
Structure and function of the chalcone synthase superfamily of plant type III polyketide synthasesQ28278420
Molecular analysis of chalcone and dihydropinosylvin synthase from Scots pine (Pinus sylvestris), and differential regulation of these and related enzyme activities in stressed plantsQ31112384
Novel type III polyketide synthases from Aloe arborescensQ33427098
Native acridone synthases I and II from Ruta graveolens L. form homodimersQ33859803
Structural and biochemical elucidation of mechanism for decarboxylative condensation of beta-keto acid by curcumin synthaseQ34154267
Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase.Q34330780
Molecular analysis of resveratrol synthase. cDNA, genomic clones and relationship with chalcone synthaseQ34402580
Benzophenone synthase from cultured cells of Centaurium erythraeaQ34407943
Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longaQ34605052
Camptothecin, over four decades of surprising findingsQ34649921
In vitro synthesis of curcuminoids by type III polyketide synthase from Oryza sativaQ34700448
Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathwayQ34981880
Identification and characterization of multiple curcumin synthases from the herb Curcuma longaQ34993281
A novel 4-hydroxycoumarin biosynthetic pathwayQ35003174
Crystallization and preliminary crystallographic analysis of a novel plant type III polyketide synthase that produces pentaketide chromoneQ36459410
The type I fatty acid and polyketide synthases: a tale of two megasynthasesQ36489362
Physcomitrella PpORS, basal to plant type III polyketide synthases in phylogenetic trees, is a very long chain 2'-oxoalkylresorcinol synthase.Q36562126
Crystallization and preliminary crystallographic analysis of an acridone-producing novel multifunctional type III polyketide synthase from Huperzia serrataQ36585226
Crystallization and preliminary crystallographic analysis of an octaketide-producing plant type III polyketide synthaseQ36588468
Crystallization and preliminary crystallographic analysis of a plant type III polyketide synthase that produces benzalacetoneQ36640760
Identification and characterization of a type III polyketide synthase involved in quinolone alkaloid biosynthesis from Aegle marmelos CorreaQ36666259
Type II polyketide synthases: gaining a deeper insight into enzymatic teamworkQ36724719
The end of an old hypothesis: the pseudomonas signaling molecules 4-hydroxy-2-alkylquinolines derive from fatty acids, not 3-ketofatty acidsQ37424462
Crystallization and preliminary X-ray diffraction studies of polyketide synthase-1 (PKS-1) from Cannabis sativaQ38272768
Expression, purification and crystallization of a plant polyketide cyclase from Cannabis sativa.Q40254719
PqsE of Pseudomonas aeruginosa Acts as Pathway-Specific Thioesterase in the Biosynthesis of Alkylquinolone Signaling Molecules.Q40954570
A Novel Class of Plant Type III Polyketide Synthase Involved in Orsellinic Acid Biosynthesis from Rhododendron dauricumQ41187863
Coding and 3' non-coding nucleotide sequence of chalcone synthase mRNA and assignment of amino acid sequence of the enzyme.Q41463063
Cloning and structure-function analyses of quinolone- and acridone-producing novel type III polyketide synthases from Citrus microcarpa.Q41958701
Expression, purification and crystallization of a plant type III polyketide synthase that produces diarylheptanoidsQ42000496
Benzophenone synthase and chalcone synthase from Hypericum androsaemum cell cultures: cDNA cloning, functional expression, and site-directed mutagenesis of two polyketide synthases.Q42601102
A single amino acid substitution converts benzophenone synthase into phenylpyrone synthase.Q42631842
Engineered biosynthesis of plant polyketides: chain length control in an octaketide-producing plant type III polyketide synthaseQ42666985
Alkylresorcylic acid synthesis by type III polyketide synthases from rice Oryza sativaQ43069777
Benzalacetone synthase. A novel polyketide synthase that plays a crucial role in the biosynthesis of phenylbutanones in Rheum palmatumQ43628342
Transformation of acridone synthase to chalcone synthaseQ43812260
Benzophenone synthase from Garcinia mangostana L. pericarpsQ45039369
An aldol switch discovered in stilbene synthases mediates cyclization specificity of type III polyketide synthasesQ45067863
Octaketide-producing type III polyketide synthase from Hypericum perforatum is expressed in dark glands accumulating hypericinsQ45075783
Starter substrate specificities of wild-type and mutant polyketide synthases from RutaceaeQ45244530
A plant type III polyketide synthase that produces pentaketide chromoneQ45247679
Microbial biosynthesis of the anticoagulant precursor 4-hydroxycoumarin.Q45363378
Identification and functional characterization of three type III polyketide synthases from Aquilaria sinensis calliQ46392174
Prokaryotic expression, polyclonal antibody preparation of the stilbene synthase gene from grape berry and its different expression in fruit development and under heat acclimationQ46397985
Two polyketide synthases are necessary for 4-hydroxy-5-methylcoumarin biosynthesis in Gerbera hybrida.Q46542177
Molecular and biochemical characterization of benzalacetone synthase and chalcone synthase genes and their proteins from raspberry (Rubus idaeus L.).Q46859318
Molecular architectures of benzoic acid-specific type III polyketide synthasesQ47106216
Chalcone synthase-like genes active during corolla development are differentially expressed and encode enzymes with different catalytic properties in Gerbera hybrida (Asteraceae).Q48074732
Structural and biochemical characterization of the plant type III polyketide synthases of the liverwort Marchantia paleacea.Q50080573
2-Alkylquinolone alkaloid biosynthesis in the medicinal plant Evodia rutaecarpa involves collaboration of two novel type III polyketide synthases.Q51057406
Crystal structure of stilbene synthase from Arachis hypogaea.Q52841312
An acridone-producing novel multifunctional type III polyketide synthase from Huperzia serrata.Q54447974
Biphenyl synthase, a novel type III polyketide synthase.Q55042717
Alternative pathways of xanthone biosynthesis in cell cultures of Hypericum androsaemum LQ57406006
Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclizationQ59789333
Grapevine stilbene synthase cDNA only slightly differing from chalcone synthase cDNA is expressed in Escherichia coli into a catalytically active enzymeQ68533422
Specificities of functionally expressed chalcone and acridone synthases from Ruta graveolensQ73129954
Enzymatic formation of unnatural novel chalcone, stilbene, and benzophenone scaffolds by plant type III polyketide synthaseQ83147936
Enzymatic formation of an aromatic dodecaketide by engineered plant polyketide synthaseQ83464568
In vitro formation of the anthranoid scaffold by cell-free extracts from yeast-extract-treated Cassia bicapsularis cell culturesQ86086614
Synthesis of Unnatural 2-Substituted Quinolones and 1,3-Diketones by a Member of Type III Polyketide Synthases from Huperzia serrataQ87864269
P433issue41
P407language of work or nameEnglishQ1860
P304page(s)15121-15136
P577publication date2019-08-30
P1433published inJournal of Biological ChemistryQ867727
P1476titleHow structural subtleties lead to molecular diversity for the type III polyketide synthases
P478volume294

Reverse relations

cites work (P2860)
Q95841072Cannabinomics: Application of Metabolomics in Cannabis (Cannabis sativa L.) Research and Development
Q91734789Natural product biosynthesis: What's next? An introduction to the JBC Reviews Thematic Series

Search more.