Hybridization capture-based next generation sequencing reliably detects FLT3 mutations and classifies FLT3-internal tandem duplication allelic ratio in acute myeloid leukemia: a comparative study to standard fragment analysis

scientific article published on 30 August 2019

Hybridization capture-based next generation sequencing reliably detects FLT3 mutations and classifies FLT3-internal tandem duplication allelic ratio in acute myeloid leukemia: a comparative study to standard fragment analysis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41379-019-0359-9
P932PMC publication ID7051912
P698PubMed publication ID31471587

P50authorRong HeQ89723283
P2093author name stringAyalew Tefferi
Dong Chen
David S Viswanatha
Kaaren K Reichard
Zheng Jin Tu
Aref Al-Kali
Phuong L Nguyen
Mrinal M Patnaik
Kebede H Begna
James D Hoyer
Jennifer L Oliveira
Hassan Alkhateeb
Ming Mai
Daniel J Devine
Paul L Ollila
P2860cites workThe role of FLT3 in haematopoietic malignanciesQ24319174
FLT3 mutations in acute myeloid leukemia: what is the best approach in 2013?Q27028163
The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemiaQ27851416
Mutations and treatment outcome in cytogenetically normal acute myeloid leukemiaQ27851430
Prognostic relevance of integrated genetic profiling in acute myeloid leukemiaQ27851726
CAP3: A DNA sequence assembly programQ27860964
Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cellsQ28138943
Detection of FLT3 internal tandem duplication in targeted, short-read-length, next-generation sequencing dataQ30577735
Amplicon Indel Hunter Is a Novel Bioinformatics Tool to Detect Large Somatic Insertion/Deletion Mutations in Amplicon-Based Next-Generation Sequencing Data.Q30990644
Selective inhibition of FLT3 by gilteritinib in relapsed or refractory acute myeloid leukaemia: a multicentre, first-in-human, open-label, phase 1-2 studyQ33442949
Diversity of the juxtamembrane and TKD1 mutations (exons 13-15) in the FLT3 gene with regards to mutant load, sequence, length, localization, and correlation with biological dataQ34295164
mTOR signaling is activated by FLT3 kinase and promotes survival of FLT3- mutated acute myeloid leukemia cellsQ34360637
Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular PathologyQ34465792
Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosisQ34523534
FLT3 in human hematologic malignanciesQ34980355
Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397Q35909096
Next-generation sequencing of FLT3 internal tandem duplications for minimal residual disease monitoring in acute myeloid leukemiaQ36356082
FLT3 D835 mutations confer differential resistance to type II FLT3 inhibitorsQ36362951
Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panelQ37624593
Acute myeloid leukemia: 2013 update on risk-stratification and managementQ38092771
Quizartinib for the treatment of FLT3/ITD acute myeloid leukemiaQ38241988
The utility of next-generation sequencing in diagnosis and monitoring of acute myeloid leukemia and myelodysplastic syndromesQ38481997
FLT3 Inhibitors in Acute Myeloid Leukemia: Current Status and Future DirectionsQ38675400
Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 MutationQ38712298
Detection the Frequency and Characteristics of FLT3 Internal Tandem Duplication Mutations by Capillary Electrophoresis Assay and Next-Generation Sequencing in.Q38977412
Clinical Validation of a Next-Generation Sequencing Genomic Oncology Panel via Cross-Platform Benchmarking against Established Amplicon Sequencing AssaysQ39194261
Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptorQ39981715
Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML.Q40330454
Leukemogenic potency of the novel FLT3-N676K mutantQ40901421
Detection of FLT3 Internal Tandem Duplication and D835 Mutations by a Multiplex Polymerase Chain Reaction and Capillary Electrophoresis AssayQ42718734
Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm.Q44189526
Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.Q53403767
Rare FLT3 deletion mutants may provide additional treatment options to patients with AML: an approach to individualized medicine.Q54270008
Targeting Oncogenic Signaling in Mutant FLT3 Acute Myeloid Leukemia: The Path to Least ResistanceQ58555667
Genomic structure of human FLT3: implications for mutational analysisQ59511715
Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemiaQ77363619
Next-generation sequencing for minimal residual disease monitoring in acute myeloid leukemia patients with FLT3-ITD or NPM1 mutationsQ83756555
A next-generation sequencing-based assay for minimal residual disease assessment in AML patients with FLT3-ITD mutationsQ88333728
P433issue3
P921main subjectacute myeloid leukemiaQ264118
P304page(s)334-343
P577publication date2019-08-30
P1433published inModern PathologyQ15724578
P1476titleHybridization capture-based next generation sequencing reliably detects FLT3 mutations and classifies FLT3-internal tandem duplication allelic ratio in acute myeloid leukemia: a comparative study to standard fragment analysis
P478volume33

Search more.