Vacuolar hydrolysis and efflux: current knowledge and unanswered questions

scientific article published on 22 November 2018

Vacuolar hydrolysis and efflux: current knowledge and unanswered questions is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1080/15548627.2018.1545821
P932PMC publication ID6333459
P698PubMed publication ID30422029

P50authorKatherine R ParzychQ93028560
Daniel J. KlionskyQ15067176
P2860cites workVacuolar sequestration of glutathione S-conjugates outcompetes a possible degradation of the glutathione moiety by phytochelatin synthaseQ79347232
Function of phytochelatin synthase in catabolism of glutathione-conjugatesQ79663081
Inactivation of PPX1 and PPN1 genes encoding exopolyphosphatases of Saccharomyces cerevisiae does not prevent utilization of polyphosphates as phosphate reserveQ79767736
Vacuolar transporter Avt4 is involved in excretion of basic amino acids from the vacuoles of Saccharomyces cerevisiaeQ87410074
Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidaseQ24308332
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonismQ24309753
The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formationQ24535862
The fungal vacuole: composition, function, and biogenesisQ24634743
Cystinosis: a reviewQ26751225
Papillon-Lefèvre syndrome: clinical presentation and management optionsQ26800252
Autophagic processes in yeast: mechanism, machinery and regulationQ26822642
The pathways of mitophagy for quality control and clearance of mitochondriaQ27009206
Global analysis of protein localization in budding yeastQ27653962
Catalytic core of a membrane-associated eukaryotic polyphosphate polymeraseQ27655151
Genomic expression programs in the response of yeast cells to environmental changesQ27860823
Glutathione metabolism in yeast Saccharomyces cerevisiae. Evidence that gamma-glutamyltranspeptidase is a vacuolar enzymeQ27930097
Characterization of an M28 metalloprotease family member residing in the yeast vacuoleQ27930098
Vacuolar amino acid transporters upregulated by exogenous proline and involved in cellular localization of proline in Saccharomyces cerevisiae.Q27930244
Aminopeptidase I of Saccharomyces cerevisiae is localized to the vacuole independent of the secretory pathwayQ27930427
Protease B of the lysosomelike vacuole of the yeast Saccharomyces cerevisiae is homologous to the subtilisin family of serine proteasesQ27930469
Disruption of a cystine transporter downregulates expression of genes involved in sulfur regulation and cellular respirationQ27930559
Aminopeptidase Y, a new aminopeptidase from Saccharomyces cerevisiae. Purification, properties, localization, and processing by protease B.Q27930985
Free-oligosaccharide control in the yeast Saccharomyces cerevisiae: roles for peptide:N-glycanase (Png1p) and vacuolar mannosidase (Ams1p)Q27931323
TOR controls translation initiation and early G1 progression in yeastQ27931425
Phytochelatins are synthesized by two vacuolar serine carboxypeptidases in Saccharomyces cerevisiaeQ27931537
A family of yeast proteins mediating bidirectional vacuolar amino acid transportQ27931648
Antagonistic controls of autophagy and glycogen accumulation by Snf1p, the yeast homolog of AMP-activated protein kinase, and the cyclin-dependent kinase Pho85pQ27931717
The vacuolar transporter chaperone (VTC) complex is required for microautophagyQ27931800
Review: biosynthesis and function of yeast vacuolar proteasesQ27932182
Identification of an evolutionarily conserved family of inorganic polyphosphate endopolyphosphatasesQ27932475
Degradation of lipid vesicles in the yeast vacuole requires function of Cvt17, a putative lipaseQ27932565
Intravacuolar membrane lysis in Saccharomyces cerevisiae. Does vacuolar targeting of Cvt17/Aut5p affect its function?Q27932809
Carboxypeptidase yscS: gene structure and function of the vacuolar enzymeQ27932825
Biogenesis of the yeast vacuole (lysosome). The precursor forms of the soluble hydrolase carboxypeptidase yscS are associated with the vacuolar membraneQ27933231
Role of vacuolar acidification in protein sorting and zymogen activation: a genetic analysis of the yeast vacuolar proton-translocating ATPaseQ27933484
Identification of yeast aspartyl aminopeptidase gene by purifying and characterizing its product from yeast cellsQ27933535
A ubiquitin-like system mediates protein lipidationQ27934137
Molecular analysis of GPH1, the gene encoding glycogen phosphorylase in Saccharomyces cerevisiaeQ27934244
Solubilization and purification of alpha-mannosidase, a marker enzyme of vacuolar membranes in Saccharomyces cerevisiae.Q27934359
Lysosomal (vacuolar) proteinases of yeast are essential catalysts for protein degradation, differentiation, and cell survivalQ27934404
Atg22 recycles amino acids to link the degradative and recycling functions of autophagyQ27934516
Phosphorylation of mitophagy and pexophagy receptors coordinates their interaction with Atg8 and Atg11.Q27934591
Nucleoside transporter proteins of Saccharomyces cerevisiae. Demonstration of a transporter (FUI1) with high uridine selectivity in plasma membranes and a transporter (FUN26) with broad nucleoside selectivity in intracellular membranesQ27934663
Vtc5, a Novel Subunit of the Vacuolar Transporter Chaperone Complex, Regulates Polyphosphate Synthesis and Phosphate Homeostasis in YeastQ27934788
Aspartyl aminopeptidase is imported from the cytoplasm to the vacuole by selective autophagy in Saccharomyces cerevisiaeQ27934838
Pho91 Is a vacuolar phosphate transporter that regulates phosphate and polyphosphate metabolism in Saccharomyces cerevisiaeQ27935048
The Saccharomyces cerevisiae YPR184w gene encodes the glycogen debranching enzyme.Q27935049
Characterization of Rny1, the Saccharomyces cerevisiae member of the T2 RNase family of RNases: unexpected functions for ancient enzymes?Q27935056
The endopolyphosphatase gene: essential in Saccharomyces cerevisiaeQ27935603
Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagyQ27936161
Structure, biosynthesis, and localization of dipeptidyl aminopeptidase B, an integral membrane glycoprotein of the yeast vacuoleQ27936549
gamma-Glutamyl transpeptidase in the yeast Saccharomyces cerevisiae and its role in the vacuolar transport and metabolism of glutathioneQ27936821
A novel family of yeast chaperons involved in the distribution of V-ATPase and other membrane proteinsQ27936896
FUN26 (function unknown now 26) protein from saccharomyces cerevisiae is a broad selectivity, high affinity, nucleoside and nucleobase transporterQ27936958
Aut5/Cvt17p, a putative lipase essential for disintegration of autophagic bodies inside the vacuoleQ27937095
Piecemeal microautophagy of nucleus in Saccharomyces cerevisiaeQ27937549
Two distinct pathways for trehalose assimilation in the yeast Saccharomyces cerevisiaeQ27937671
Correlations between genotype, ultrastructural morphology and clinical phenotype in the neuronal ceroid lipofuscinosesQ34427575
Prevalence of lysosomal storage disordersQ34489300
rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA.Q34508701
THE SYNDROME OF PALMAR-PLANTAR HYPERKERATOSIS AND PREMATURE PERIODONTAL DESTRUCTION OF THE TEETH. A CLINICAL AND GENETIC ANALYSIS OF THE PAPILLON-LEF'EVRE SYNDROME.Q34541221
InterPro in 2017-beyond protein family and domain annotationsQ34546171
Cathepsin D deficiency is associated with a human neurodegenerative disorderQ34658270
The natural course of infantile Pompe's disease: 20 original cases compared with 133 cases from the literatureQ35191008
Mutant defective in processing of an enzyme located in the lysosome-like vacuole of Saccharomyces cerevisiaeQ35309290
The transmembrane domain of acid trehalase mediates ubiquitin-independent multivesicular body pathway sortingQ35901885
Genetics of the neuronal ceroid lipofuscinoses (Batten disease).Q36053005
The Papillon-Lefèvre syndrome: keratosis palmoplantaris with periodontopathy. Report of a case and review of the cases in the literatureQ36144647
Polyphosphate is a novel pro-inflammatory regulator of mast cells and is located in acidocalcisomesQ36217204
Processing pathway for protease B of Saccharomyces cerevisiaeQ36220063
Role for Lipid Droplet Biogenesis and Microlipophagy in Adaptation to Lipid Imbalance in Yeast.Q36371807
The where, when, and how of organelle acidification by the yeast vacuolar H+-ATPaseQ36416690
Glycogenolytic enzymes in sporulating yeastQ36421118
The PEP4 gene encodes an aspartyl protease implicated in the posttranslational regulation of Saccharomyces cerevisiae vacuolar hydrolasesQ36463508
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's diseaseQ36611426
Nucleus-vacuole junctions and piecemeal microautophagy of the nucleus in S. cerevisiaeQ36699879
The structure and function of Saccharomyces cerevisiae proteinase A.Q36797191
Novel families of vacuolar amino acid transportersQ37155663
Autophagy and mistargeting of therapeutic enzyme in skeletal muscle in Pompe diseaseQ37219555
The yeast lysosome-like vacuole: endpoint and crossroadsQ37266848
Resolution of organelle docking and fusion kinetics in a cell-free assayQ37415422
Regulation of autophagy in yeast Saccharomyces cerevisiaeQ37432448
UniProt: the universal protein knowledgebaseQ37556842
Proteases in autophagyQ37884674
Selective autophagy in budding yeastQ38019315
Lysosomal storage diseases--the horizon expandsQ38128478
Revisiting yeast trehalose metabolism.Q38248254
Phosphorylation of Serine 114 on Atg32 mediates mitophagyQ38274635
A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein.Q38304477
Identification of direct and indirect targets of the Gln3 and Gat1 activators by transcriptional profiling in response to nitrogen availability in the short and long termQ38311053
Regulation of glycogen metabolism in yeast and bacteriaQ34082070
Direct labeling of polyphosphate at the ultrastructural level in Saccharomyces cerevisiae by using the affinity of the polyphosphate binding domain of Escherichia coli exopolyphosphataseQ34098041
Reserve carbohydrate metabolism in Saccharomyces cerevisiae: responses to nutrient limitationQ34153582
Cathepsin A/protective protein: an unusual lysosomal multifunctional proteinQ34158565
PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursorsQ34162725
New insights on trehalose: a multifunctional moleculeQ34182431
Yeast aminopeptidase I chemical composition and catalytic propertiesQ34229180
The substrate specificity of proteinase B from baker's yeastQ34276369
PINK1 mutations are associated with sporadic early-onset parkinsonismQ34345883
Incorporation of [32P]orthophosphate into long chains of inorganic polyphosphate within lysosomes of human fibroblastsQ54275455
Osteopetrosis acro-osteolytica. A syndrome of osteopetrosis, acro-osteolysis and open sutures of the skullQ56422237
The Yeast Vacuolar Membrane ProteomeQ57016848
Storage lipid synthesis is necessary for autophagy induced by nitrogen starvationQ57652100
pH-dependent processing of yeast procarboxypeptidase Y by proteinase A in vivo and in vitroQ61447128
Purification and characterization of acid trehalase from the yeast suc2 mutantQ68140092
Glutathione as an endogenous sulphur source in the yeast Saccharomyces cerevisiaeQ68300331
A novel pathway of import of alpha-mannosidase, a marker enzyme of vacuolar membrane, in Saccharomyces cerevisiaeQ68641687
Substrate specificity of proteinase yscA from saccharomyces cerevisiaeQ69107669
Localization of trehalase in vacuoles and of trehalose in the cytosol of yeast (Saccharomyces cerevisiae)Q70260509
Deletion of the ATH1 gene in Saccharomyces cerevisiae prevents growth on trehaloseQ71118524
An analysis of the sequence of part of the right arm of chromosome II of S. cerevisiae reveals new genes encoding an amino-acid permease and a carboxypeptidaseQ72790957
Acidification of vacuoles is required for autophagic degradation in the yeast, Saccharomyces cerevisiaeQ73194510
A new class of mutants deficient in dodecamerization of aminopeptidase 1 and vacuolar transportQ73384035
An important role for glutathione and gamma-glutamyltranspeptidase in the supply of growth requirements during nitrogen starvation of the yeast Saccharomyces cerevisiaeQ73457194
Disruption of the yeast ATH1 gene confers better survival after dehydration, freezing, and ethanol shock: potential commercial applications.Q27937684
Cystinosin, the protein defective in cystinosis, is a H(+)-driven lysosomal cystine transporterQ27937730
New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysisQ27937759
Phosphate-responsive signaling pathway is a novel component of NAD+ metabolism in Saccharomyces cerevisiaeQ27937830
Isolation and characterization of aminopeptidase mutants of Saccharomyces cerevisiaeQ27938002
Membrane protein sorting: biosynthesis, transport and processing of yeast vacuolar alkaline phosphataseQ27938078
Piecemeal microautophagy of the nucleus requires the core macroautophagy genes.Q27938479
Studies on the hydrolytic properties of (serine) carboxypeptidase Y.Q27938746
Characterization and localization of the sporulation glucoamylase of Saccharomyces cerevisiaeQ27938815
Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targetingQ27938877
ATG15 encodes a phospholipase and is transcriptionally regulated by YAP1 in Saccharomyces cerevisiaeQ27939209
A phylogenetic analysis of the sugar porters in hemiascomycetous yeastsQ27939877
Localization, regulation, and substrate transport properties of Bpt1p, a Saccharomyces cerevisiae MRP-type ABC transporterQ27939913
Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapyQ27940141
Nucleus-vacuole junctions in Saccharomyces cerevisiae are formed through the direct interaction of Vac8p with Nvj1pQ27940306
ERS1 encodes a functional homologue of the human lysosomal cystine transporterQ27940319
Membrane trafficking in the yeast Saccharomyces cerevisiae modelQ28084192
Coupled synthesis and translocation restrains polyphosphate to acidocalcisome-like vacuoles and prevents its toxicityQ28249718
GlutathioneQ28261279
The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pumpQ28278194
Reserve carbohydrates metabolism in the yeast Saccharomyces cerevisiaeQ28611243
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicineQ29547303
Autophagy regulates lipid metabolismQ29547421
Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its inductionQ29614187
The role of the Atg1/ULK1 complex in autophagy regulationQ29614497
A sterol-enriched vacuolar microdomain mediates stationary phase lipophagy in budding yeastQ30585890
Molecular cloning and sequencing of genomic DNA encoding yeast vacuolar carboxypeptidase yscS.Q33263367
Structure-function relationships of acid ribonucleases: lysosomal, vacuolar, and periplasmic enzymesQ33586639
Carboxypeptidase Y: structural basis for protein sorting and catalytic triadQ33678734
Lysosomal multienzyme complex: pros and cons of working togetherQ33682632
Inorganic polyphosphate: a molecule of many functions.Q33711952
Lysosomal cysteine proteases: more than scavengersQ33857460
The frequency of lysosomal storage diseases in The Netherlands.Q33873527
Golgi-to-late endosome trafficking of the yeast pheromone processing enzyme Ste13p is regulated by a phosphorylation site in its cytosolic domainQ33914482
PyknodysostosisQ33972531
Mitophagy in yeast: Molecular mechanisms and physiological roleQ38325180
Lipid droplet dynamics in budding yeastQ38430663
Autophagy and Lipid Droplets in the LiverQ38528206
Enzymes of yeast polyphosphate metabolism: structure, enzymology and biological roles.Q38728117
An overview of macroautophagy in yeastQ38747554
Role of vacuoles in phosphorus storage and remobilizationQ38771707
Emerging connections between RNA and autophagy.Q38974926
Inherited diseases caused by mutations in cathepsin protease genes.Q39031727
48 Carboxypeptidase YQ39132649
Function of lipid droplet-organelle interactions in lipid homeostasisQ39229018
Enzymes required for yeast prohormone processingQ39644456
The signaling pathways underlying starvation-induced upregulation of α-mannosidase Ams1 in Saccharomyces cerevisiae.Q39944999
The coordinated action of the MVB pathway and autophagy ensures cell survival during starvationQ40429659
Transcriptional control of the sporulation-specific glucoamylase gene in the yeast Saccharomyces cerevisiaeQ40676306
Metabolism and functions of glutathione in micro-organismsQ40708669
Vacuolar/lysosomal proteolysis: proteases, substrates, mechanismsQ40725810
Yeast aminopeptidase I is post-translationally sorted from the cytosol to the vacuole by a mechanism mediated by its bipartite N-terminal extensionQ40789894
α-d-mannosidase of Saccharomyces cerevisiae Characterization and modulation of activityQ40897200
Subcellular localization and levels of aminopeptidases and dipeptidase in Saccharomyces cerevisiaeQ40964248
Biogenesis of the yeast lysosome (vacuole): biosynthesis and maturation of proteinase yscBQ41107319
Biogenesis of the yeast vacuole (lysosome). Active site mutation in the vacuolar aspartate proteinase yscA blocks maturation of vacuolar proteinasesQ41172605
Studies on a Carboxypeptidase Y Mutant of Yeast and Evidence for a Second Carboxypeptidase ActivityQ41236401
Maturation of vacuolar (lysosomal) enzymes in yeast: proteinase yscA and proteinase yscB are catalysts of the processing and activation event of carboxypeptidase yscY.Q41346111
Ppn2, a novel Zn2+-dependent polyphosphatase in the acidocalcisome-like yeast vacuole.Q41792144
Lipid droplet autophagy in the yeast Saccharomyces cerevisiaeQ41869124
Congenital ceroid-lipofuscinosisQ41930547
Glutathione participates in the regulation of mitophagy in yeastQ42052870
Protein degradation, meiosis and sporulation in proteinase-deficient mutants of Saccharomyces cerevisiaeQ42178696
Structure of the lysosomal neuraminidase-beta-galactosidase-carboxypeptidase multienzymic complexQ42271895
The proteolytic landscape of the yeast vacuoleQ42574320
Lipid droplets and their component triglycerides and steryl esters regulate autophagosome biogenesisQ42580800
Nitrogen-source regulation of yeast gamma-glutamyl transpeptidase synthesis involves the regulatory network including the GATA zinc-finger factors Gln3, Nil1/Gat1 and Gzf3.Q43002795
Bulk RNA degradation by nitrogen starvation-induced autophagy in yeastQ43084554
Avt5p is required for vacuolar uptake of amino acids in the fission yeast Schizosaccharomyces pombeQ43101127
Dissection of glutathione conjugate turnover in yeastQ43246342
The Saccharomyces cerevisiae vacuolar acid trehalase is targeted at the cell surface for its physiological function.Q43287040
The ATP-binding cassette (ABC) transporter Bpt1p mediates vacuolar sequestration of glutathione conjugates in yeast.Q44014759
A retrospective, multinational, multicenter study on the natural history of infantile-onset Pompe diseaseQ44312356
Phytochelatin synthase catalyzes key step in turnover of glutathione conjugatesQ44349244
Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeastQ44674184
RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection.Q46209097
Lap4, a vacuolar aminopeptidase I, is involved in cadmium-glutathione metabolism.Q46419363
Activation of the proteinase B precursor of the yeast Saccharomyces cerevisiae by autocatalysis and by an internal sequenceQ47857305
Mitophagy in neurodegenerative diseasesQ47967084
A newly characterized vacuolar serine carboxypeptidase, Atg42/Ybr139w, is required for normal vacuole function and the terminal steps of autophagy in the yeast Saccharomyces cerevisiaeQ50420468
A vacuolar membrane protein Avt7p is involved in transport of amino acid and spore formation in Saccharomyces cerevisiaeQ50448793
Induction of autophagy by phosphate starvation in an Atg11-dependent manner in Saccharomyces cerevisiae.Q51237804
Systematic identification of the genes affecting glycogen storage in the yeast Saccharomyces cerevisiae: implication of the vacuole as a determinant of glycogen level.Q51711914
Endopolyphosphatase in Saccharomyces cerevisiae undergoes post-translational activations to produce short-chain polyphosphates.Q52563403
Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation.Q53665783
ATP-dependent transport of reduced glutathione on YCF1, the yeast orthologue of mammalian multidrug resistance associated proteins.Q54114460
Activities and cellular localization of yeast proteases and their inhibitorsQ54188004
P433issue2
P304page(s)212-227
P577publication date2018-11-22
P1433published inAutophagyQ1255295
P1476titleVacuolar hydrolysis and efflux: current knowledge and unanswered questions
P478volume15

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cites work (P2860)
Q64258466Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity
Q92972669Dynamic Regulation of the 26S Proteasome: From Synthesis to Degradation
Q89655663TORC1 regulates vacuole membrane composition through ubiquitin- and ESCRT-dependent microautophagy

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