Physiologically-Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid-to-Lactone Conversion

scientific article published on 01 August 2019

Physiologically-Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid-to-Lactone Conversion is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/PSP4.12447
P932PMC publication ID6765700
P698PubMed publication ID31250974

P2093author name stringStephen D Hall
Gemma L Dickinson
Bridget L Morse
Corina Loghin
Maria M Posada
Anil Kolur
Kathleen M Hillgren
Lai San Tham
Jeffrey J Alberts
Jessica Rehmel
P2860cites workGrapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatinQ28142865
Atorvastatin transport in the Caco-2 cell model: contributions of P-glycoprotein and the proton-monocarboxylic acid co-transporterQ28375489
Itraconazole alters the pharmacokinetics of atorvastatin to a greater extent than either cerivastatin or pravastatinQ33924086
Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolitesQ34440964
Clinical Pharmacokinetics of AtorvastatinQ35553211
Effect of cytochrome P450 3A5 genotype on atorvastatin pharmacokinetics and its interaction with clarithromycin.Q37017426
Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorptionQ38056878
Validation of a microdose probe drug cocktail for clinical drug interaction assessments for drug transporters and CYP3A.Q38726643
Physiologically Based Pharmacokinetic (PBPK) Modeling of Pitavastatin and Atorvastatin to Predict Drug-Drug Interactions (DDIs).Q39178447
effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteersQ40189578
Effects of single nucleotide polymorphisms and haplotypes of the SLCO1B1 gene on the pharmacokinetic profile of atorvastatin in healthy Macedonian volunteersQ40536775
Physiologically based pharmacokinetic modeling of disposition and drug-drug interactions for atorvastatin and its metabolitesQ40791912
Prediction of clinical irrelevance of PK differences in atorvastatin using PK/PD models derived from literature-based meta-analysesQ40868027
Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach.Q41759104
Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatinQ42284010
Association of genetic variations with pharmacokinetics and lipid-lowering response to atorvastatin in healthy Korean subjectsQ42291683
Transport vs. Metabolism: What Determines the Pharmacokinetics and Pharmacodynamics of Drugs? Insights From the Extended Clearance ModelQ42682232
Effect of Semaglutide on the Pharmacokinetics of Metformin, Warfarin, Atorvastatin and Digoxin in Healthy Subjects.Q43246916
UDP-glucuronosyltransferase (UGT) polymorphisms affect atorvastatin lactonization in vitro and in vivoQ43268896
Pharmacokinetic interaction studies of co-administration of ticagrelor and atorvastatin or simvastatin in healthy volunteersQ43449319
Effect of gemfibrozil and fenofibrate on the pharmacokinetics of atorvastatinQ44991444
Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin.Q45949072
ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvastatin.Q45993642
Effect of efavirenz on the pharmacokinetics of simvastatin, atorvastatin, and pravastatin: results of AIDS Clinical Trials Group 5108 StudyQ46568560
Effect of AGTR1 and BDKRB2 gene polymorphisms on atorvastatin metabolism in a Mexican populationQ47110674
No Dose Adjustment is Recommended for Digoxin, Warfarin, Atorvastatin or a Combination Oral Contraceptive When Coadministered with DulaglutideQ48345845
Simultaneous quantitation of atorvastatin and its two active metabolites in human plasma by liquid chromatography/(-) electrospray tandem mass spectrometry.Q50056643
Evaluation of Drug-Drug Interaction Potential Between Sacubitril/Valsartan (LCZ696) and Statins Using a Physiologically Based Pharmacokinetic Model.Q50952394
Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole.Q51634445
Different Effects of SLCO1B1 Polymorphism on the Pharmacokinetics of Atorvastatin and RosuvastatinQ57825140
The interconversion kinetics, equilibrium, and solubilities of the lactone and hydroxyacid forms of the HMG-CoA reductase inhibitor, CI-981Q72685071
Effect of itraconazole on the pharmacokinetics of atorvastatinQ77057428
Erythromycin coadministration increases plasma atorvastatin concentrationsQ77422016
Bioavailability of amlodipine besylate/atorvastatin calcium combination tabletQ80142362
Atorvastatin glucuronidation is minimally and nonselectively inhibited by the fibrates gemfibrozil, fenofibrate, and fenofibric acidQ80241790
Effect of food on the bioavailability of amlodipine besylate/atorvastatin calcium combination tabletQ80305695
Effect of omega-3-acid ethyl esters on steady-state plasma pharmacokinetics of atorvastatin in healthy adultsQ82593313
Effect on the Gastrointestinal Absorption of Drugs from Different Classes in the Biopharmaceutics Classification System, When Treating with LiraglutideQ86350083
UGT1A1*28 is associated with decreased systemic exposure of atorvastatin lactoneQ86582913
P433issue9
P304page(s)664-675
P577publication date2019-08-01
P1433published inCPT: pharmacometrics & systems pharmacologyQ27724610
P1476titlePhysiologically-Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid-to-Lactone Conversion
P478volume8

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Q90146101A hybrid model to evaluate the impact of active uptake transport on hepatic distribution of atorvastatin in ratscites workP2860

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