Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

scientific article published on 14 April 2019

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0140-6736(19)30772-X
P698PubMed publication ID30995972

P50authorPeter MaxwellQ38545687
John McMurrayQ56633150
Sheldon W. TobeQ58091532
Maria Teresa ZanellaQ72210750
Klemens BuddeQ72992120
Svetlana VillevaldeQ85915225
Dick de ZeeuwQ86373033
Iuliia SamoilovaQ93174405
Dalane W KitzmanQ114291605
P2093author name stringHirofumi Makino
Vlado Perkovic
George Bakris
Hans-Henrik Parving
Tingting Yi
Dennis L Andress
Ricardo Correa-Rotter
Fan-Fan Hou
Hiddo J L Heerspink
Donald Kohan
Pablo E Pergola
Melissa Wigderson
Michael G Miller
Joel Z Melnick
SONAR Committees and Investigators
P2860cites workAvosentan reduces albumin excretion in diabetics with macroalbuminuriaQ24642372
The endothelin antagonist atrasentan lowers residual albuminuria in patients with type 2 diabetic nephropathyQ28237978
Cardiorenal end points in a trial of aliskiren for type 2 diabetesQ28278569
Avosentan for overt diabetic nephropathyQ33702404
Endothelin and endothelin antagonists in chronic kidney diseaseQ34437692
Addition of atrasentan to renin-angiotensin system blockade reduces albuminuria in diabetic nephropathyQ34726905
Endothelin A receptor blockade reduces diabetic renal injury via an anti-inflammatory mechanismQ36965292
The effects of atrasentan on urinary metabolites in patients with type 2 diabetes and nephropathyQ38778059
Atrasentan Reduces Albuminuria by Restoring the Glomerular Endothelial Glycocalyx Barrier in Diabetic Nephropathy.Q39748148
Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL.Q40509707
Is a reduction in albuminuria associated with renal and cardiovascular protection? A post hoc analysis of the ALTITUDE trial.Q41173770
Management of patients with diabetes and CKD: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies ConferenceQ42068388
The endothelin receptor antagonist avosentan ameliorates nephropathy and atherosclerosis in diabetic apolipoprotein E knockout mice.Q43253718
The risk of developing end-stage renal disease in patients with type 2 diabetes and nephropathy: the RENAAL studyQ44358769
Combined angiotensin inhibition for the treatment of diabetic nephropathyQ46129784
Rationale and protocol of the Study of Diabetic Nephropathy with Atrasentan (SONAR) trial: A clinical trial design novel to diabetic nephropathyQ48098900
Baseline characteristics and enrichment results of the Study Of diabetic Nephropathy with AtRasentan (SONAR) trial.Q51731767
Haemodynamic and renal effects of endothelin receptor antagonism in patients with chronic kidney diseaseQ56987897
Unselective inhibition of endothelin receptors reduces renal dysfunction in experimental diabetesQ57985156
Endothelin antagonism reduces circulating galectin-3 in patients with proteinuric chronic kidney diseaseQ64446874
Unmet need in diabetic nephropathy: failed drugs or trials?Q89398640
Change in albuminuria and subsequent risk of end-stage kidney disease: an individual participant-level consortium meta-analysis of observational studiesQ91009115
Change in albuminuria as a surrogate endpoint for progression of kidney disease: a meta-analysis of treatment effects in randomised clinical trialsQ91009119
P433issue10184
P921main subjecttype 2 diabetesQ3025883
placeboQ269829
chronic renal insufficiencyQ736715
placebo-controlled trialQ108853737
P304page(s)1937-1947
P577publication date2019-04-14
P1433published inThe LancetQ939416
P1476titleAtrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial
P478volume393