Cellular DNAJA3, a Novel VP1-Interacting Protein, Inhibits Foot-and-Mouth Disease Virus Replication by Inducing Lysosomal Degradation of VP1 and Attenuating Its Antagonistic Role in the Beta Interferon Signaling Pathway

scientific article published on 14 June 2019

Cellular DNAJA3, a Novel VP1-Interacting Protein, Inhibits Foot-and-Mouth Disease Virus Replication by Inducing Lysosomal Degradation of VP1 and Attenuating Its Antagonistic Role in the Beta Interferon Signaling Pathway is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.00588-19
P932PMC publication ID6580959
P698PubMed publication ID30996089

P2093author name stringJunwu Ma
Fan Yang
Yang Yang
Wei Zhang
Linlin Li
Zhifang Wang
Haixue Zheng
Zixiang Zhu
Hong Tian
Xiangtao Liu
Keshan Zhang
Yongjie Liu
Weijun Cao
Ruoqing Mao
Wen Dang
P2860cites workThe two-hybrid system: an assay for protein-protein interactionsQ72755047
Control of foot-and-mouth disease by vaccinationQ73221657
Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagyQ24676280
Identification and characterization of the host protein DNAJC14 as a broadly active flavivirus replication modulatorQ28476726
Biological and chemical approaches to diseases of proteostasis deficiencyQ29616633
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activationQ30404141
DnaJ homolog Hdj2 facilitates Japanese encephalitis virus replicationQ31038877
Hsp40 facilitates nuclear import of the human immunodeficiency virus type 2 Vpx-mediated preintegration complexQ33306788
Foot-and-mouth disease virus virulent for cattle utilizes the integrin alpha(v)beta3 as its receptor.Q33782587
The human DnaJ protein, hTid-1, enhances binding of a multimer of the herpes simplex virus type 1 UL9 protein to oris, an origin of viral DNA replicationQ34011483
Mitochondrial chaperone DnaJA3 induces Drp1-dependent mitochondrial fragmentationQ34275630
The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune responseQ34353443
Foot-and-mouth disease virus nonstructural protein 2C interacts with Beclin1, modulating virus replication.Q34397749
Foot-and-mouth diseaseQ34547126
DnaJA1/Hsp40 is co-opted by influenza A virus to enhance its viral RNA polymerase activityQ34595028
The leader proteinase of foot-and-mouth disease virus negatively regulates the type I interferon pathway by acting as a viral deubiquitinaseQ35076546
Antibodies to the vitronectin receptor (integrin alpha V beta 3) inhibit binding and infection of foot-and-mouth disease virus to cultured cellsQ35838328
Tid1, the Mammalian Homologue of Drosophila Tumor Suppressor Tid56, Mediates Macroautophagy by Interacting with Beclin1-containing Autophagy Protein ComplexQ35859547
Translation and replication of FMDV RNA.Q36008129
The structure of foot-and-mouth disease virusQ36008134
Establishment and evaluation of a murine ανβ3-integrin-expressing cell line with increased susceptibility to Foot-and-mouth disease virusQ36105475
Foot-and-mouth disease virus 3C protease cleaves NEMO to impair innate immune signalingQ36154825
Degradation of nuclear factor kappa B during foot-and-mouth disease virus infectionQ36315811
Analysis of the interaction between host factor Sam68 and viral elements during foot-and-mouth disease virus infectionsQ36398263
Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteinsQ36448856
The heat shock protein 70 cochaperone YDJ1 is required for efficient membrane-specific flock house virus RNA replication complex assembly and function in Saccharomyces cerevisiaeQ36483294
Foot-and-mouth disease virus non-structural protein 3A inhibits the interferon-β signaling pathwayQ36587775
HSP70 binding protein 1 (HspBP1) suppresses HIV-1 replication by inhibiting NF-κB mediated activation of viral gene expressionQ36627905
Foot-and-mouth disease virus structural protein VP3 degrades Janus kinase 1 to inhibit IFN-γ signal transduction pathwaysQ36838447
Foot-and-mouth disease virus modulates cellular vimentin for virus survivalQ36911808
The Critical Role Of VP1 In Forming The Necessary Cavities For Receptor-mediated Entry Of FMDV To The Host CellQ36959441
Innate immune responses against foot-and-mouth disease virus: current understanding and future directionsQ37332207
Foot-and-Mouth Disease Virus Viroporin 2B Antagonizes RIG-I-Mediated Antiviral Effects by Inhibition of Its Protein ExpressionQ37448319
Interaction of foot-and-mouth disease virus nonstructural protein 3A with host protein DCTN3 is important for viral virulence in cattleQ37644085
Foot-and-mouth disease virus infection suppresses autophagy and NF-кB antiviral responses via degradation of ATG5-ATG12 by 3Cpro.Q37744980
Heat shock protein 40 (Hsp40) plays a key role in the virus life cycleQ37897736
The VP3 structural protein of foot-and-mouth disease virus inhibits the IFN-β signaling pathwayQ38799259
Molecular Mechanisms of Foot-and-Mouth Disease Virus Targeting the Host Antiviral ResponseQ39403774
The costs of preventive activities for exotic contagious diseases-A Danish case study of foot and mouth disease and swine feverQ39470791
The epithelial integrin alphavbeta6 is a receptor for foot-and-mouth disease virusQ39584959
Foot-and-mouth disease virus utilizes an autophagic pathway during viral replicationQ39626629
Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced type I interferon transcription by decreasing interferon regulatory factor 3/7 in protein levelsQ39679047
Integrin alphavbeta1 is a receptor for foot-and-mouth disease virusQ39682189
Novel viral disease control strategy: adenovirus expressing alpha interferon rapidly protects swine from foot-and-mouth diseaseQ39699303
High affinity binding between Hsp70 and the C-terminal domain of the measles virus nucleoprotein requires an Hsp40 co-chaperoneQ39806166
Turnover of hepatitis B virus X protein is facilitated by Hdj1, a human Hsp40/DnaJ protein.Q40255670
Negative regulation of hepatitis B virus replication by cellular Hsp40/DnaJ proteins through destabilization of viral core and X proteinsQ40270299
Heat shock protein 40 is necessary for human immunodeficiency virus-1 Nef-mediated enhancement of viral gene expression and replicationQ40369976
Nucleotide sequence and genome organization of foot-and-mouth disease virusQ40461503
VP1 of foot-and-mouth disease virus induces apoptosis via the Akt signaling pathwayQ40507762
Integrin alphavbeta8 functions as a receptor for foot-and-mouth disease virus: role of the beta-chain cytodomain in integrin-mediated infection.Q40567879
LSm14A Plays a Critical Role in Antiviral Immune Responses by Regulating MITA Level in a Cell-Specific MannerQ40673144
The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones.Q40839196
Foot-and-mouth disease virus induces autophagosomes during cell entry via a class III phosphatidylinositol 3-kinase-independent pathwayQ41169445
Structure of the foot-and-mouth disease virus leader protease: a papain-like fold adapted for self-processing and eIF4G recognitionQ42151087
Interaction of Hsp40 with influenza virus M2 protein: implications for PKR signaling pathwayQ42772395
Foot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1.Q45324396
Engagement of soluble resistance-related calcium binding protein (sorcin) with foot-and-mouth disease virus (FMDV) VP1 inhibits type I interferon response in cellsQ45350762
Biochemical and functional characterization of Epstein-Barr virus-encoded BARF1 protein: interaction with human hTid1 protein facilitates its maturation and secretionQ45419158
Delineation of a neutralizing subregion within the immunodominant epitope (GH loop) of foot-and-mouth disease virus VP1 which does not contain the RGD motif.Q45747044
The cell attachment site on foot-and-mouth disease virus includes the amino acid sequence RGD (arginine-glycine-aspartic acid).Q45845848
Neutralizing antibodies to all seven serotypes of foot-and-mouth disease virus elicited by synthetic peptidesQ45851828
RGD-containing peptides of VP1 of foot-and-mouth disease virus (FMDV) prevent virus infection in vitroQ45860482
Innate immune sensor LGP2 is cleaved by the Leader protease of foot-and-mouth disease virusQ56979762
FMDV leader protease cleaves G3BP1 and G3BP2 and inhibits stress granule formationQ58598695
The Pseudoknot Region of the 5' Untranslated Region Is a Determinant of Viral Tropism and Virulence of Foot-and-Mouth Disease VirusQ64080909
P433issue13
P921main subjectfoot-and-mouth diseaseQ152401
foot-and-mouth disease virusQ1911079
P577publication date2019-06-14
P1433published inJournal of VirologyQ1251128
P1476titleCellular DNAJA3, a Novel VP1-Interacting Protein, Inhibits Foot-and-Mouth Disease Virus Replication by Inducing Lysosomal Degradation of VP1 and Attenuating Its Antagonistic Role in the Beta Interferon Signaling Pathway
P478volume93

Reverse relations

cites work (P2860)
Q95836398Cholesterol 25-hydroxylase inhibits encephalomyocarditis virus replication through enzyme activity-dependent and independent mechanisms
Q93037526Foot-and-Mouth Disease Virus 3A Protein Causes Upregulation of Autophagy-Related Protein LRRC25 To Inhibit the G3BP1-Mediated RIG-Like Helicase-Signaling Pathway
Q94545027Porcine DNAJB6 promotes PCV2 replication via enhancing the formation of autophagy in host cells
Q97528833Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development

Search more.